摘要
目的:通过优化肠炎宁颗粒辅料种类,改善药品口感,使其更易为患者接受,提高临床用药顺应性,增加患者服药依从性。方法:通过对肠炎宁颗粒不同辅料组合进行分组实验,优化辅料加入方式,从而调节本品口感。结果:优化后以糊精、乳糖、三氯蔗糖作为矫味剂,适当减少乳糖的用量。选用矫味剂三氯蔗糖调节本品口感,辅料调整后,其颗粒的装量为每袋2 g。结论:调整辅料后生产工艺更易于控制,增加了本品的甜味并掩盖苦味,改善本品的口感,使其嗅觉、味觉让儿童患者更易接受,而不增加辅料服用总量,可提高临床用药依从性。
Objective: This study aims to optimize the types of Changyanning granule excipients,improve the taste of this product,which make it more acceptable to patients,and improve the compliance of clinical medication,thereby increasing the compliance of patients with medication. Methods: Through screening experiments on different excipient combinations of Changyanning Granules,the way of adding excipients was optimized to adjust the taste of the product. Results: After optimization,dextrin,lactose and sucralose were used as flavor modifiers to reduce the amount of lactose. Sucralose was selected as flavor modifier to adjust the taste of the product. After adjustment of adjuvants,the volume of granules was 2 g per bag. Conclusion: After adjusting the excipients,the production process is easier to control,the sweetness and bitterness of the product are increased,the taste of the product is improved,the faction and taste of the product are more acceptable to children patients,and the compliance of clinical medication can be improved without increasing the total amount of excipients taken.
引文
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