摘要
目的观察促生长激素神经肽(Gal)对高糖诱导的背根神经节(DRG)神经元损伤的保护作用。方法构建高糖处理的DRG神经元体外模型,研究Gal对DRG神经元细胞活力及凋亡的影响。结果高糖引起细胞活力降低,并促进细胞凋亡。外源性Gal抑制了高糖对细胞产生的上述效应。结论 Gal参与了高糖诱导DRG神经元损伤,外源性Gal对神经元具有显著的保护作用。
引文
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