摘要
目的观察柴胡疏肝散加味辅助治疗儿童抽动障碍(TD)肝郁脾虚型的临床疗效。方法选取2016年4月至2018年1月在我院中西医结合儿科门诊就诊的TD肝郁脾虚型患儿160例,按照随机数字表法分为对照组58例和治疗组102例。对照组予阿立哌唑片口服,早晚各1次。治疗组在对照组治疗方法的基础上给予柴胡疏肝散加味,1剂/d,早晚分服。2组均1月为1个疗程,治疗3个疗程后统计2组的临床疗效以及不良反应发生情况。结果对照组总有效率为72.4%,治疗组为93.1%,2组比较,差异有统计学意义(P<0.05)。对照组总不良反应发生率为22.41%,治疗组为1.96%,2组比较,差异有统计学意义(P<0.01)。结论柴胡疏肝散加味辅助治疗儿童TD肝郁脾虚型疗效显著,不良反应小,值得临床推广应用。
Objective To observe the clinical efficacy of modified Chaihu Shugan San(柴胡疏肝散) in adjuvant treatment of tic disorder in children with stagnation of the liver-qi and deficiency of the spleen type.Methods Totally 160 children with tic disorder admitted in outpatient service of pediatrics department of integrated traditional Chinese and Western medicine in our hospital from April 2016 to January 2018 were chosen and divided into control group with 58 cases and treatment group with 102 cases according to random number table method.The control group was given oral aripiprazole tablets,once in the morning and once in the evening, respectively.The treatment group was given modified Chaihu Shugan San on the basis of the control group,one dose daily,took in the morning and evening separately.The 2 groups were both treated for 1 month as a course of treatment.After 3 courses,we kept statistics of the clinical efficacy and the incidence of adverse reactions of the 2 groups.Results The total effective rate of the control group was 72.4%,that of the treatment group was 93.1%,there was statistically significant difference between the two groups(P<0.05).The total incidence of adverse reactions of the control group was 22.41%,that of the treatment group was 1.96%,there was statistically significant difference between the two groups(P<0.01).Conclusion Modified Chaihu Shugan San in adjuvant treatment of tic disorder in children with stagnation of the liver-qi and deficiency of the spleen type has significant clinical efficacy and less adverse reactions,which is worthy of clinical promotion and application.
引文
[1]中华医学会儿科学分会神经学组.儿童抽动障碍的诊断与治疗建议[J]. 中华儿科杂志, 2013,51(1):72-75.
[2]American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: DSM-5[M]. Arlington, VA: American Psychiatric Publishing,2013: 936.
[3]中华中医药学会. 中医儿科常见病诊疗指南[M]. 北京: 中国中医药出版社, 2012:123-126.
[4]汪受传. 中医儿科学[M]. 北京: 中国中医药出版社,2002:12-16.
[5]郑筱萸. 中药新药临床研究指导原则(试行) [M]. 北京:中国医药科技出版社, 2002:421-426.
[6]李丹,李宜瑞,何玲云,等.儿童抽动秽语综合征相关危险因素分析[J].中医儿科杂志,2015,31(20):269-270.
[7]刘智胜.儿童抽动障碍诊断要点[J].中国实用儿科杂志,2012,27(7):481-485.
[8]刘智胜.Tourette综合征共患病的诊治进展[J].中国儿童保健杂志,2010,18(2):94-99.
