摘要
理解大脑的工作机制是人类科学发展的终极命题,2013年欧盟和美国相继宣布投入大量资金开展新一轮的脑研究计划,我国也于2016年推出中国的脑研究计划。脑科学研究不仅是当下神经科学的研究前沿,更是解决神经精神疾病带来的日益增加的社会负担的突破口。本文总结了世界主要发达国家的脑研究计划进展,并重点介绍我国脑计划的布局、展开及优势,以期为广大科研工作者提供最新的脑科学研究国际动向和国内发展情况。
Understanding the working mechanism of the brain is the ultimate proposition for the development of human science.In 2013,the European Union and the United States announced that they had invested large funds to carry out a new round of brain research programs,and China also launched a brain research program in 2016.Brain science research is not only the frontier of neuroscience research,but also the breakthrough to solve the increasing social burden caused by neuropsychiatric diseases.This paper summarizes the progress of brain research projects in major developed countries in the world,and emphatically introduces the layout,development and advantages of brain projects in China,in order to provide the latest international and domestic development situation of brain science research for the majority of scientific researchers.
引文
[1]Murray C J,Vos T,Lozano R,et al.Disability-adjusted life years(DALYs)for 291 diseases and injuries in 21 regions,1990-2010:a systematic analysis for the Global Burden of Disease Study 2010[J].Lancet,2012,380(9859):2197-2223.
[2]Roehrig C.Mental Disorders Top The List Of The Most Costly Conditions In The United States:$201 Billion[J].Health Aff,2016,35(6):1130.
[3]Neurology T L.The Human Brain Project:mutiny on the flagship[J].Lancet Neurology,2014,13(1):855.
[4]Amunts K,Lindner A,Zilles K.The human brain project:neuroscience perspectives and German contributions[J].Neuroforum,2014,5(2):43-50.
[5]顾凡及.欧盟人脑计划进入正式实施阶段[J].科学,2017,69(4):23-26.
[6]欧盟脑计划网址http://www.humanbrainproject.eu
[7]Allen脑计划网址http://www.alleninstitute.org/
[8]Oh S W,Harris J A,Ng L,et al.A mesoscale connectome of the mouse brain[J].Nature,2014,508(7495):207.
[9]Sunkin S M,Ng L,Lau C,et al.Allen Brain Atlas:an integrated spatio-temporal portal for exploring the central nervous system[J].Nucleic acids research,2012,41(D1):D996-D1008.
[10]Allen脑图谱网址http://www.brain-map.org/
[11]Essen D C V,Smith S M,Barch D M,et al.The WU-Minn Human Connectome Project:An Overview[J].Neuroimage,2013,80(8):62-79.
[12]Bargmann C I,Newsome W T.The Brain Research Through Advancing Innovative Neurotechnologies(BRAIN)initiative and neurology[S].2014:675-676.
[13]美国脑计划网址http:/www.brain-map.org/
[14]Insel T R,Landis S C,Collins F S.The NIH BRAINInitiative[J].Science,2013,340(6133):687.
[15]蒲慕明,徐波,谭铁牛.脑科学与类脑研究概述[J].中国科学院院刊,2016,31(7):725-736.
[16]王亚,李永欣,黄文华.人类脑计划的研究进展[J].中国医学物理学杂志,2016,33(2):109-112.
[17]Cyranoski D.Marmosets are stars of Japan’s ambitious brain project[J].Nature,2014,514(7521):151-152.
[18]Okano H,Sasaki E,Yamamori T,et al.Brain/MINDS:AJapanese National Brain Project for Marmoset Neuroscience[J].Neuron,2016,92(3):582.
[19]Okano H,Mitra P.Brain-mapping projects using the common marmoset[J].Neuroscience Research,2015,93:3-7.
[20]Okabe S.Brain/MINDS-a new program for comprehensive analyses of the brain[J].Microscopy,2015,64(1):3.
[21]日本脑计划官网http://brainminds.jp
[22]中华人民共和国科学技术部网址http://www.most.gov.cn/
[23]王喆辰.“人类脑科学研究计划”:谁来圆梦[J].生理学报,2013,65(4):466-468.
[24]张旭,刘力,郭爱克.“脑功能联结图谱与类脑智能研究”先导专项研究进展和展望[J].中国科学院院刊,2016(7):737-746.
[25]张亚卓.中国脑计划与神经外科发展[J].中华神经外科杂志,2017,33(1):1-3.
[26]Mu M.Whereto the mega brain projects[J].National Science Review,2014,1(1):12-14.
[27]Poo M M,Du J L,Ip N,et al.China Brain Project:Basic Neuroscience,Brain Diseases,and Brain-Inspired Computing[J].Neuron,2016,92(3):591-596.
[28]沈政.脑功能理论的当代发展和前沿研究计划[J].科学通报,2017(30):3429-3439.
[29]杨雄里.对中国脑科学研究的思考[J].科技导报,2013,31(35):3.
[30]Wang L.Mu-ming Poo:China Brain Project and the future of Chinese neuroscience[J].National Science Review,2017,4(2):258-263.
[31]Cyranoski D.Monkey kingdom[J].Nature,2016,532(7599):300.
[32]Grillner S,Ip N,Koch C,et al.Worldwide initiatives to advance brain research[J].Nature Neuroscience,2016,19(9):1118-1122.
[33]骆清铭.需求导向,基础领先,技术取胜[J].中国科学:生命科学,2016,46(2):206-207.
[34]曾毅,刘成林,谭铁牛.类脑智能研究的回顾与展望[J].计算机学报,2016,39(1):212-222.
