摘要
目的探究湿润烧伤膏联合医用胶原蛋白海绵在慢性难愈性窦道中的应用效果。方法选取2017年1月至2018年4月德阳市人民医院整形烧伤美容外科收治的46例慢性难愈性窦道患者作为研究对象,并按照随机数表法将其随机分为观察组(23例)与对照组(23例),其中观察组患者采用湿润烧伤膏联合医用胶原蛋白海绵治疗局部创面,对照组患者单纯采用湿润烧伤膏治疗局部创面,对比观察不同时间点两组患者的临床疗效、疼痛程度及肉芽组织评分情况。结果治疗2周后,观察组患者治疗总有效率为69. 57%,对照组患者治疗总有效率为34. 78%;治疗4周后,观察组患者治疗总有效率为82. 61%,对照组患者治疗总有效率为52. 17%。两组患者治疗2、4周后临床疗效对比,P均<0.05,差异具有统计学意义。治疗1周后,观察组患者中轻度疼痛者10例、中度疼痛者10例、重度疼痛者3例,肉芽组织评分为0～1分者1例、2～3分者4例、4分者18例,明显优于对照组患者中的轻度疼痛者5例、中度疼痛者8例、重度疼痛者10例,肉芽组织评分为0～1分者3例、2～3分者9例、4分者11例,P均<0.05,差异具有统计学意义;治疗2周后,观察组患者中轻度疼痛者15例、中度疼痛者8例,肉芽组织评分为2～3分者2例、4分者21例,明显优于对照组患者中的轻度疼痛者9例、中度疼痛者7例、重度疼痛者7例,肉芽组织评分为0～1分者2例、2～3分者8例、4分者13例,P均<0.05,差异具有统计学意义。结论湿润烧伤膏联合医用胶原蛋白海绵可有效促进慢性难愈性窦道创面肉芽组织的生长.加快创面愈合,减轻创面疼痛,疗效显著,值得临床推广应用。
Objective To investigate the effect of application of MEBT/MEBO in combination with medical collagen sponge in treating chronic refractory sinus. Methods Forty-six patients with chronic hard-to-healing sinus admitted into the Burns and Plastic Surgery Department of People's Hospital of Deyang City between January 2017 and April 2018 were randomly divided into an observation group(23 cases) and a control group(23 cases) according to the random number table. The local wounds in the observation group were treated with MEBO in combination with medical collagen sponge, while the wounds in the control group were simply given MEBO. The clinical efficacy, pain score and granulation tissue score were observed and compared between the two groups at different time points. Results Two weeks after treatment, the total effective rate in the observation group was 69. 57% while that in the control group was 34. 78%. Four weeks after treatment, the total effective rate was 82. 61% while that in the control group was 52. 17%. The comparison of clinical efficacy between the two groups at respective two and four weeks after treatment both showed statistically significant differences(P <0. 05). One week after treatment, in the observation group mild pain was observed in 10 patients, moderate pain in 10 patients and severe pain in 3 patients, one patient had the granulation tissue score ranging 0-1 point, 4 patients had the granulation tissue score ranging 2-3 points and 18 patients had 4 points of the granulation tissue score, while in the control group mild pain in 5 patients, moderate pain in 8 patients, severe pain in 10 patients, granulation tissue score 0-1 point in 3 patients,2-3 points in 9 patients and 4 points in 11 patients, which all showed statistically significant differences as compared between the two groups, P <0. 05. Two weeks after treatment, in the observation group mild pain in 15 patients, moderate pain in 8 patients, granulation tissue score 2-3 points in 2 patients and 4 points in 21 patients, which were markedly superior to that in the control group-mild pain in 9 patients, moderate pain in 7 patients, severe pain in 7 patients, 0-1 point in 2 patients, 2-3 points in 8 patients, 4 points in 13 patients, all P <0. 05. Conclusion MEBO in combination with medical collagen sponge can effectively promote the growth of granulation tissues in chronic hard-to-healing sinus wounds,speed up wound healing and alleviate wound pain, deserving to be promoted in clinical practice.
引文
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