多种油脂肪乳(SMOF)干预对食管癌术后应激激素、炎性介质及免疫功能的影响
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  • 英文篇名:Effects of lipid emulsion(SMOF)intervention on stress hormones,inflammatory mediators and immune function after esophagus cancer operation
  • 作者:曾亚兰 ; 绍勇 ; 兰仲军
  • 英文作者:ZENG Ya-lan;SHAO Yong;LAN Zhong-jun;Oncology Department No.1 Ward,West China Hospital,Sichuan University in Sichuan Province;Pharmacy Department,Chengdu West Hospital in Sichuan Province;
  • 关键词:食管癌 ; 多种油脂肪乳 ; 应激反应 ; 炎症反应 ; 转录因子
  • 英文关键词:Esophageal cancer;;SMOF;;Stress response;;Inflammatory response;;Transcription factor
  • 中文刊名:HNYY
  • 英文刊名:Journal of Hainan Medical University
  • 机构:四川省四川大学华西医院肿瘤一病房;四川省成都市西区医院药剂科;
  • 出版日期:2017-11-20 17:32
  • 出版单位:海南医学院学报
  • 年:2017
  • 期:v.23;No.197
  • 基金:四川省科技计划项目(2015SZ0157)~~
  • 语种:中文;
  • 页:HNYY201722012
  • 页数:4
  • CN:22
  • ISSN:46-1049/R
  • 分类号:48-51
摘要
目的:研究多种油脂肪乳(SMOF)干预对食管癌术后应激激素、炎性介质及免疫功能的影响。方法:选择2015年6月~2017年3月期间在四川大学华西医院接受食管癌根治术的84例患者并随机分为两组,SMOF组采用SMOF多种油脂肪乳配置肠外营养,对照组采用长链脂肪乳配置肠外营养。干预前及干预后3天、7天时,检测血清中应激激素、炎性介质的含量以及外周血单个核细胞中免疫转录因子的mRNA表达量。结果:两组患者干预后血清中NE、E、DA、Cor、SP-D、MIP-2、TNF-α的含量以及外周血中GATA3、Foxp3的mRNA表达量均高于干预前,外周血中T-bet、RORγt的mRNA表达量均低于干预前;SMOF组患者干预后血清中NE、E、DA、Cor、SP-D、MIP-2、TNF-α的含量以及外周血中GATA3、Foxp3的mRNA表达量均低于对照组,外周血中T-bet、RORγt的mRNA表达量显著高于对照组。结论:多种油脂肪乳干预能够减轻食管癌术后的应激反应及炎症反应,改善免疫应答。
        Objective:To study the effects of lipid emulsion(SMOF)intervention on stress hormones,inflammatory mediators and immune function after esophagus cancer operation.Methods:Total of 84 patients who received radical operation for esophageal cancer in West China Hospital,Sichuan University between June 2015 and March 2017 were selected and randomly divided into two groups,SMOF group received parenteral nutrition configured by SMOF lipid emulsion,and control group received parenteral nutrition configured by long chain lipid emulsion.Before intervention as well as 3 days and 7 days after intervention,the levels of stress hormones and inflammatory mediators in serum and the mRNA expression of immune transcription factors in peripheral blood mononuclear cells were detected.Results:Serum NE,E,DA,Cor,SP-D,MIP-2 and TNF-αlevels as well as peripheral blood GATA3 and Foxp3 mRNA expression of both groups of patients after intervention were higher than those before intervention while peripheral blood T-bet and RORγt mRNA expression were lower than those before intervention;serum NE,E,DA,Cor,SP-D,MIP-2 and TNF-αlevels as well as peripheral blood GATA3 and Foxp3 mRNA expression of SMOF group after intervention were lower than those of control group while peripheral blood T-bet and RORγt mRNA expression were higher than those of control group.Conclusions:Lipid emulsion(SMOF)intervention can reduce the stress response and inflammatory response after esophageal cancer operation,and improve the immune response.
引文
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