摘要
糖尿病是以高血糖为主要特征的代谢性疾病,随着发病率逐年升高,已成为影响人类健康与生存的疾病之一。脑微血管并发症是患者致残及致死的主要原因之一,发病机制是在高血糖的基础上,信号转导通路受损、氧化应激、多元醇代谢异常、血脂异常、血液流变学异常等相关因素共同作用所致。临床上多表现为出血性和缺血性疾病,早期诊断对临床及时治疗,控制病情发展有重要作用,除糖化血红蛋白、磷酸肌酸等常用的生化指标及常规影像检查外,功能成像技术目前已成为病变检出的有力手段。
Diabetes is a metabolic disease characterized by hyperglycemia. As the incidence increases year by year,it has become one of the diseases affecting human health and survival. Cerebral microvascular complication is one of the main causes of disability and death in patients. The pathogenesis is based on hyperglycemia,signal transduction pathway damage,oxidative stress,abnormal polyol metabolism,dyslipidemia,abnormal blood rheology and other related factors. Clinically,hemorrhagic and ischemic diseases are often manifested. Early diagnosis plays an important role in timely clinical treatment and control of disease development. In addition to commonly used biochemical indicators such as glycosylated hemoglobin and phosphocreatine and routine imaging examination,functional imaging technology has become a powerful means of detecting lesions.
引文
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