环磷酰胺诱导的小鼠骨髓抑制模型及中药对其防治作用机制研究进展

详细信息    查看全文 | 推荐本文 |

英文篇名：Mouse Model of Cyclophosphamide-Induced Myelosuppression and Research Progress on Mechanism of Action of Chinese Meteria Medica in its treatment and prevention 作者：王成龙 ; 赵东峰 ; 杨志烈 ; 贾友冀 ; 常君丽 ; 王拥军 ; 杨燕萍 英文作者：Wang Chenglong;Zhao Dongfeng;Yang Zhilie;Jia Youji;Chang Junli;Wang Yongjun;Yang Yanping;Spine institute,Longhua Hospital,Shanghai University of Traditional Chinese Medicine;Central Laboratory for Research,Longhua Hospital,Shanghai University of Traditional Chinese Medicine;Integrated Chinese and Western Medicine College,Binzhou Medical College;Department of Orthopedics,Ruijin Hospital,Shanghai Jiao-Tong University Medical School; 关键词：环磷酰胺 ; 化疗 ; 骨髓抑制 ; 小鼠模型 ; 机制研究 英文关键词：Cyclophosphamide;;Chemotherapy;;Myelosuppression;;Mouse model;;Study of Mechanism 中文刊名：SJZA 英文刊名：World Chinese Medicine 机构：上海中医药大学附属龙华医院脊柱病研究所;上海中医药大学附属龙华医院科技中心实验室;滨州医学院中西医结合学院;上海交通大学医学院附属瑞金医院骨科; 出版日期：2017-09-25 06:40 出版单位：世界中医药 年：2017 期：v.12 基金：国家自然科学基金项目(81202708,81373667,81674006) 语种：中文; 页：SJZA201709064 页数：6 CN：09 ISSN：11-5529/R 分类号：273-278

摘要

化疗后骨髓抑制容易导致患者发生感染或出血,严重影响患者治疗、预后和生命质量,甚至危及生命,给患者及家属带来很大痛苦。中医药防治化疗导致骨髓抑制越来越受到重视。随着骨髓抑制动物模型的建立、应用和成熟,中药防治化疗导致骨髓抑制机制的研究也取得许多进展,显出中药治疗的优势和前景。
        Patients with chemotherapy-induced myelosuppression is prone to infection or bleeding,which has a serious impact on their treatment,prognosis and quality of life and even endangers life and leads patients and their family to suffering. In recent years,traditional Chinese medicine in preventing and treating chemotherapy-induced myelosuppression have gradually garnered increasing attention. As the animal model of myelosuppression is being established,applied and mature,research on mechanism of Chinese meteria medica in preventing and treating chemotherapy-induced myelosuppression has made great achievements,showing the advantages and prospect of Chinese meteria medica in the treatment of this disease.

引文

[1]李欣娜,李魏.骨髓抑制动物模型建立方法综述[J].黑龙江医药,2008,21(2):24-27.
    [2]殷霁虹,沈小珩.中药对恶性肿瘤化学治疗引起骨髓抑制的干预作用动物实验研究进展[J].上海中医药大学学报,2010,24(1):78-80.
    [3]Adams GB,Martin RP,Alley IR,et al.Therapeutic targeting of a stem cell niche[J].Nat Biotechnol,2007,25(2):238-43.
    [4]Feng L,Huang Q,Huang Z,et al.Optimized Animal Model of Cyclophosphamide-induced Bone Marrow Suppression[J].Basic Clin Pharmacol Toxicol,2016,119(5):428-435.
    [5]Li W,Zhao Y,Li X.Effect of Zishenshengxue capsule on myelosuppression in mice induced by cyclophosphamide[J].J Tradit Chin Med,2013,33(2):233-237.
    [6]Patra K,Bose S,Sarkar S,et al.Amelioration of cyclophosphamide induced myelosuppression and oxidative stress by cinnamic acid[J].Chem Biol Interact,2012,195(3):231-239.
    [7]Salva S,Marranzino G,Villena J,et al.Probiotic Lactobacillus strains protect against myelosuppression and immunosuppression in cyclophosphamide-treated mice[J].Int Immunopharmacol,2014,22(1):209-921.
    [8]Sun HX,Peng XY.Protective effect of triterpenoid fractions from the rhizomes of Astilbe chinensis on cyclophosphamide-induced toxicity in tumor-bearing mice[J].J Ethnopharmacol,2008,119(2):312-317.
    [9]唐振,李世杰,王颖飞,等.化疗减毒汤对环磷酰胺致骨髓抑制小鼠的保护机制研究[J].中国全科医学,2015,18(27):3360-3365.
    [10]王立芳,徐振晔,金长娟,等.双黄升白颗粒对Lewis肺癌荷瘤鼠细胞周期双重调控的研究[J].上海中医药杂志,2009,43(2):56-59.
    [11]王涛,刘薇,庄辉传,等.复方甘草酸苷注射液对小鼠放、化疗模型减毒作用实验研究[J].中国现代应用药学,2013,30(9):943-948.
    [12]王兴海,曹瑞,张波,等.维血宁对环磷酰胺致骨髓抑制模型小鼠的WBC、RBC、PLT和Hb的影响[J].西北药学杂志,2011,26(5):354-356.
    [13]谢强,黄丽萍,柳勤.生血丸对环磷酰胺所致小鼠骨髓抑制的影响[J].中国病理生理杂志,2003,19(8):1117-1118.
    [14]Xu M,He RR,Zhai YJ,et al.Effects of carnosine on cyclophosphamide-induced hematopoietic suppression in mice[J].Am J Chin Med,2014,42(1):131-142.
    [15]严苏纯,祝彼得,陈志伟.几种骨髓抑制性贫血小鼠模型的比较研究[J].成都中医药大学学报,2007,30(1):31-34.
    [16]杨岚,祝彼得,彭成.血虚证动物模型的标准化研究初探[J].四川动物,2006,25(1):160-164.
    [17]Yang Y,Xu S,Xu Q,et al.Protective effect of dammarane sapogenins against chemotherapy-induced myelosuppression in mice[J].Exp Biol Med(Maywood),2011,236(6):729-735.
    [18]Yu Q,Nie SP,Wang JQ,et al.Chemoprotective effects of Ganoderma atrum polysaccharide in cyclophosphamide-induced mice[J].Int J Biol Macromol,2014,64:395-401.
    [19]赵喜新,阎杜海,王和平,等.环磷酰胺引致的小鼠白细胞减少模型及动力学分析[J].上海实验动物科学,1998,18(1):12-14.
    [20]周武斌,徐之良.当归注射液对环磷酰胺损伤小鼠骨髓细胞组织形态及超微结构的保护作用[J].咸宁学院学报:医学版,2007,21(1):13-15.
    [21]徐振晔,朱晏伟,周卫东,等.双黄升白冲剂对化疗引起骨髓抑制的临床研究及小鼠骨髓超微结构的观察[J].中国中西医结合杂志,2001,21(5):328-331.
    [22]Zhu XL,Liu JH,Li WD,et al.Promotion of myelopoiesis in myelosuppressed mice by Ganoderma lucidum polysaccharides[J].Front Pharmacol,2012,3(Article 20):1-7.
    [23]Diaz-Montero CM,Wang Y,Shao L,et al.The glutathione disulfide mimetic NOV-002 inhibits cyclophosphamide-induced hematopoietic and immune suppression by reducing oxidative stress[J].Free Radic Biol Med,2012,52(9):1560-1568.
    [24]Xu SF,Yu LM,Fan ZH,et al.Improvement of ginsenoside Rg1 on hematopoietic function in cyclophosphamide-induced myelosuppression mice[J].Eur J Pharmacol,2012,695(1-3):7-12.
    [25]Wang S,Xu ZY,Wang LF.Shuanghuang Shengbai granule cures myelosuppression and suppresses lung cancer progression:mechanism and therapeutic targets from the aspect of microRNAs[J].Oncotarget,2017,Jul 10.doi:10.18632/oncotarget.19129.
    [26]Méndez-Ferrer S,Michurina TV,Ferraro F,et al.Mesenchymal and haematopoietic stem cells form a unique bone marrow niche[J].Nature,2010,466(7308):829-834.
    [27]费成明,常春康.成骨细胞在造血微环境中的作用及与部分血液系统疾病关系的研究进展[J].中国实验血液学杂志,2014,22(4):1133-1136.
    [28]章婧嫽,竺晓凡.骨髓间充质干细胞缺陷与获得性再生障碍性贫血[J].中国当代儿科杂志,2015,19(1):100-106.
    [29]Kiel MJ,Yilmaz OH,Iwashita T,et al.SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells[J].Cell,2005,121(7):1109-1121.
    [30]陈海琳,张福鹏,周永明.骨髓造血微环境及中药调控作用研究进展[J].中成药,2010,32(7):1183-1188.
    [31]王鹤潼,王立芳,徐振晔,等.双黄升白颗粒对小鼠化疗骨髓抑制期骨髓EGFR信号通路的调控作用[J].上海中医药杂志,2014,48(10):93-98.
    [32]王立芳,徐振晔,司海龙,等.双黄升白颗粒对化疗所致骨髓抑制Lewis肺癌荷瘤鼠Notch信号通路的双重调控作用[J].上海中医药大学学报,2015,29(6):45-49.
    [33]Chen X,Li B,Gao Y,et al.Saponins from Sanguisorba officinalis Improve Hematopoiesis by Promoting Survival through FAK and Erk1/2 Activation and Modulating Cytokine Production in Bone Marrow[J].Front Pharmacol,2017,8:130.
    [34]Gu X,Xu ZY,Zhu LY,et al.Dual control of Shuanghuang Shengbai granule on upstream and downstream signal modulators of Cyclin DCDK4/6 signaling pathway of cell cycle in Lewis-bearing mice with cyclophosphamide-induced myelosuppression[J].Onco Targets Ther,2013,6:199-209.
    [35]程卓,赵文豪,吕叙鹏,等.石见穿多糖对环磷酰胺诱导小鼠免疫低下的调节作用[J].中药材,2016,39(1):183-187.
    [36]钟金凤,方热军.环磷酰胺免疫抑制机制及在动物模型上的应用[J].中国免疫学杂志,2016,32(10):1541-1546.
    [37]蒋立峰,桑锋,蒋士卿,等.精元康胶囊对骨髓抑制小鼠骨髓细胞凋亡相关基因表达水平的影响[J].中国实验方剂学杂志,2011,17(12):119-122.
    [38]黄威峰,张长城,刘静,等.五子衍宗方对环磷酰胺致成年雄性小鼠睾丸生殖细胞凋亡的保护作用[J].中药材,2016,39(5):1143-1147.
    [39]王米,王宵旸,张丽芳,等.蛹虫草多糖对注射环磷酰胺小鼠抗氧化功能的影响[J].中国畜牧兽医,2016,43(12):3251-3256.
    [40]刘静,张长城,宋来新,等.五子衍宗方对环磷酰胺致成年雄性小鼠睾丸生殖细胞DNA损伤及P53通路的影响[J].中药材,2017,40(1):183-187.