摘要
目的探究青春期与育龄期痰湿证多囊卵巢综合征(PCOS)患者的临床特征及代谢差异性。方法选择痰湿证PCOS患者434例进行研究,按照年龄将患者分为青春期组123例和育龄期组311例,分析并比较2组患者的临床特征及代谢指标的差异。结果青春期组患者年龄、初潮年龄及血清卵泡刺激素(FSH)、血清黄体生成素(LH)、空腹血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白B(ApoB)/载脂蛋白A(ApoA)均明显低于育龄期组(P均<0. 05),而多毛及溢脂发生率和血清睾酮(T)、硫酸脱氢表雄酮(DHEAS)、雄烯二酮(AND)、低密度脂蛋白胆固醇(LDL-C)、ApoA、ApoB均明显高于育龄期组(P均<0. 05)。结论痰湿证PCOS在青春期与育龄期所表现出的临床特征、代谢特征不同,青春期患者初潮年龄较早,多毛及溢脂发生率较高,且以雄激素水平过高为主,育龄期患者以性激素及糖脂代谢障碍为主。
Objective It is to explore the clinical features and metabolic difference of adolescent and reproductive patients with polycystic ovarian syndrome(PCOS) of phlegm damp type. Methods A total of 434 patients with PCOS were enrolled in the study. The patients were divided into 123 cases of puberty group and 311 cases of childbearing age group according to age. The differences in the clinical characteristics and metabolic indexes of the two groups were analyzed and compared. Results The age,age at menarche,the levels of serum follicle stimulating hormone(FSH),serum luteinizing hormone(LH),fasting blood glucose(FPG),total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),apolipoprotein B(Apo B)/apolipoprotein A(Apo A) were significantly lower in puberty group than those in the childbearing age group(P < 0. 05),while the incidence of hairy and lipid leakage and the levels of serum testosterone(T),dehydrogenation of sulfuric acid Epiandrosterone(DHEAS),androstenedione(AND),low density lipoprotein cholesterol(LDL-C),Apo A,Apo B were significantly higher than those in the childbearing age group(P < 0. 05). Conclusion The clinical and metabolic characteristics are different between adolescent patients and reproductive patients with PCOS of phlegm damp type,the incidence of hairy and excess fat are higher and menstruation age is early in adolescent patients,higher testosterone levels were mainly found in adolescent patients,while serious sex hormone and glucolipid metabolic abnormalities were mainly found in childbearing age patients.
引文
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