摘要
采用表面增强拉曼光谱(SERS)技术并结合简单的前处理流程,对保健品样品中11种西地那非类药物进行了非定向快速筛查研究.结果表明,11种西地那非类药物可根据结构分为5类,类别之间SERS谱图差异显著;类别内SERS谱图具有共性特征,特征峰相对强度差异明显.实际样品的检测中,西地那非类药物的最低检出浓度约为0.05 mg/kg;前处理和测试的总时长约为3~5 min,且与检测目标物和样品无关.本方法高灵敏度、快速和非定向检测的设计理念为快速检测保健品中违禁添加药物提供了新思路和新方法.
Aiming at the absence of a fast and effective screening technique facing the prevalence of the illegal adulterant of Phosphodiesterase type 5( PDE-5) inhibitor in health products,a non-designated detection platform based on surface-enhanced Raman spectroscopy( SERS) was proposed. Integrated with a simple pretreatment process in 3—5 min,SERS measurement was carried out on those suspicious health product samples with the lowest detectable concentration at a level of 0. 05 mg/kg. The advantages of short time and high sensitivity satisfy the urgent demand of the fast screening and on-site inspection of the authorities.
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