摘要
目的:评价益肾补脾加减方对慢性肾脏病(CKD)3期脾肾气虚证患者生活质量的影响。方法:60例CKD3期患者随机分为治疗组30例和对照组30例,两组患者均给予常规西医治疗,治疗组在西医治疗基础上采用益肾补脾方加减,观察治疗前后生活质量量表、中医证候积分、血清白蛋白、血红蛋白、肾小球滤过率、血肌酐、血尿素氮的改变。结果:(1)两组患者中医证候总积分的比较:治疗组与基础治疗对照组比较,治疗组更能明显改善中医证候总积分(P<0.01);(2)两组患者生活质量量表各维度积分的比较:治疗组与对照组比较,中医辨证治疗组更能明显改善生活质量(P<0.01);(3)两组患者中医临床症状的比较:中医辨证治疗组对倦怠乏力、气短懒言、腰膝酸软、肢体困重、食少纳差等中医症状的改善明显优于基础治疗对照组(P<0.01);(4)两组患者理化检查指标的比较:中医辨证治疗组对改善患者肾小球滤过率、血肌酐、血尿素氮、血清蛋白、血红蛋白等方面明显优于基础治疗对照组(P<0.01)。结论:益肾补脾加减方可明显改善CKD3期脾肾气虚证患者临床症状和提高患者生命质量,延缓慢性肾脏病病程的进展。
Objective: To evaluate the Effect of Spleen- invigorating and kidney- tonifying decoction on the Quality of life in deficiency of spleen and kidney Patients With Chronic Kidney Disease at the 3 Stage. Methods: 60 cases with CKD 3 stage were randomly divided into control group( n = 30) and thetreatment group( n = 40). The two groups were given conventional western medicine therapy,the experimental group on this basis,dialectics and to Spleen- invigorating and kidney- tonifying treatment. After12 weeks of treatment,the charger of quality of life scale,TCM syndrome integral points,serum albumin,hemoglobin,glomerular filtration rate,serum creatinine,blood urea nitrogen were observed. Results:( 1) Compared two groups of patients with TCM syndrome total score: TCM treatment group and the control group comparison,TCM treatment group can significantly improve the TCM syndrome total score( P < 0. 01).( 2) Two patients quality of life scale integral comparison: TCM treatment group and control group comparison,TCM treatment group can obviously improve the quality of life( P < 0. 01).( 3) Compared two groups of patients with clinical symptoms of TCM: TCM treatment group of fatigue,shortness of breath,Yaoxisuanruan,heaviness in the body,eat less anorexia and other symptoms of traditional Chinese medicine is better than the basic treatment control group( P < 0. 01).( 4) Patients in the two group comparison of physical and chemical indexes: TCM treatment group to the control group improved in patients with glomerular filtration rate,serum creatinine,blood urea nitrogen,serum protein,hemoglobin and other aspects of treatment is obviously better than the foundation( P < 0. 01). Conclusion: Spleen- invigorating and kidney- tonifying decoction on the Quality of life in deficiency of spleen and kidney Patients With Chronic Kidney Disease at the 3 Stage,can obviously improve the clinical symptoms and improve the life quality of patients with stable renal function,and can slowing the end- stage renal disease( ESRD) happened.
引文
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