摘要
<正>急性间质性肾炎(AIN)是导致急性肾损伤(AKI)的重要原因之一。AIN的主要病理表现为肾间质炎细胞浸润,通常不伴肾小球病变。在慢性肾小球肾炎基础上发生的AIN的临床病理表现与单纯AIN、慢性肾小球肾炎继发间质损害有一定区别。本科室近期连续诊治2例IgA肾病合并急性间质性肾炎患者,现报告如下。
引文
[1]PRAGA M, SEVILLANO A, AU?óN P, et al. Changes in the aetiology, clinical presentation and management of acute interstitial nephritis, an increasingly common cause of acute kidney injury[J]. Nephrol Dial Transplant, 2015, 30(9):1472-1479.
[2]刘红,丁小强,滕杰,等. 急性间质性肾炎的临床病理分析[J]. 中华肾脏病杂志, 2006,22(4):248-249.
[3]丁小强,傅辰生,药物所致急性间质性肾炎[J]. 中华肾脏病杂志,2005,21(3):123-124.
[4]PRAGA M, GONZáLEZ E. Acute interstitial nephritis[J]. Kidney Int, 2010, 77(11):956-961.
[5]CLARKSON M R, GIBLIN L, O'CONNELL F P, et al. Acute interstitial nephritis: clinical features and response to corticosteroid therapy[J]. Nephrol Dial Transplant. 2004, 19(11):2778-2783.
[6]GONZáLEZ E, GUTIéRREZ E, GALEANO C, et al. Early steroid treatment improves the recovery of renal function in patients with drug-induced acute interstitial nephritis[J]. Kidney Int, 2008, 73(8):940-946.
[7]PRENDECKI M, TANNA A, SALAMA A D, et al. Long-term outcome in biopsy-proven acute interstitial nephritis treated with steroids[J]. Clin Kidney J, 2017, 10(2):233-239.
[8]MURIITHI A K, LEUNG N, VALERI A M, et al. Biopsy-proven acute interstitial nephritis, 1993-2011: a case series[J]. Am J Kidney Dis, 2014, 64(4):558-566.