摘要
子宫内膜异位症(endometriosis,EMS)是不孕症的常见病因,HOXA10、HOXA11这2种基因的正常表达与子宫内膜分泌中、晚期容受性的形成关系密切,而这2种基因在EMS患者的子宫内膜中与正常人相比表达下降,故EMS不孕的主要机制可能为低表达的HOXA10、HOXA11这2种基因,使子宫内膜的蜕膜化异常、容受性下降。此外,近期研究指出,导致EMS患者HOXA10、HOXA11基因表达下降的主要因素可能是基因异常甲基化。
The expressions of HOXA10 and HOXA11 were reduced in endometrium who were suffering endometriosis(EMS), a common cause of infertility, compared with normal person. Furthermore, HOXA10 and HOXA11 are closely associated with endometrial receptivity of middle and late secretory phase. Abnormal decidualization and decreased endometrial receptivity may be the primary mechanisms of EMS infertility, according to the low expression level of HOXA10 and HOXA11. Additionally, aberrant methylation may be the major factor for the two genes' reduced expression according to recent studies.
引文
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