Safety and efficacy of ultrasound ciliary plasty as a primary intervention in glaucoma patients
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  • 英文篇名:Safety and efficacy of ultrasound ciliary plasty as a primary intervention in glaucoma patients
  • 作者:Magda ; A.Torky ; Yousif ; A ; Al ; Zafiri ; Sherein ; M.Hagras ; Abeer ; M.Khattab ; Rania ; M.Bassiouny ; Tharwat ; H.Mokbel
  • 英文作者:Magda A.Torky;Yousif A Al Zafiri;Sherein M.Hagras;Abeer M.Khattab;Rania M.Bassiouny;Tharwat H.Mokbel;Department of Ophthalmology, Faculty of Medicine, Mansoura University;Department of Ophthalmology, Dar AlS hifa Hospital;
  • 英文关键词:ultrasound ciliary plasty;;glaucoma;;intraocular pressure
  • 中文刊名:GYZZ
  • 英文刊名:国际眼科杂志(英文版)
  • 机构:Department of Ophthalmology, Faculty of Medicine, Mansoura University;Department of Ophthalmology, Dar AlS hifa Hospital;
  • 出版日期:2019-04-12 11:37
  • 出版单位:International Journal of Ophthalmology
  • 年:2019
  • 期:v.12
  • 语种:英文;
  • 页:GYZZ201904012
  • 页数:6
  • CN:04
  • 分类号:73-78
摘要
AIM: To evaluate the safety and the efficacy of the ultrasound ciliary plasty(UCP) on the intraocular pressure(IOP) control in glaucomatous eyes without previous glaucoma surgery.METHODS: A retrospective study included patients with primary and secondary glaucoma who underwent UCP in Dar Al Shifa Hospital, Kuwait between January 2017 to June 2018. High-intensity focused ultrasound procedures were performed under peribulbar anesthesia using the 2~(nd) generation probe with 8 s duration of each of the 6 shots. Complete ophthalmologic examinations were scheduled pre-treatment, and at 1 d, 1 wk, 1, 3, 6 and 12 mo posttreatment. Primary outcomes were the IOP reduction and success rates at 12 mo, while the secondary outcomes were the occurrence of vision threatening complications and visual acuity.RESULTS: The records of 62 eyes of 62 patients were analyzed with mean age of 63.8 y(67.7% males). There was statistically significant reduction in the mean IOP from 35.2±8.3 mm Hg before treatment to 20.6±8.7 mm Hg at 12~(th) month(P<0.0005) with a mean percentage IOP reduction of 42.3% with significant reduction in the mean number of antiglaucomatous drugs from 3.2±0.4 before treatment to 2.1±1.02 at 12 mo(P<0.0005). Qualified success was achieved in 77.4% of eyes at 12 mo. No major intra-or posttreatment complications were reported.CONCLUSION: Second-generation UCP prove to be effective in reducing IOP in naive glaucoma patients with lower success rates in cases of neovascular and uveitic glaucomas.
        AIM: To evaluate the safety and the efficacy of the ultrasound ciliary plasty(UCP) on the intraocular pressure(IOP) control in glaucomatous eyes without previous glaucoma surgery.METHODS: A retrospective study included patients with primary and secondary glaucoma who underwent UCP in Dar Al Shifa Hospital, Kuwait between January 2017 to June 2018. High-intensity focused ultrasound procedures were performed under peribulbar anesthesia using the 2~(nd) generation probe with 8 s duration of each of the 6 shots. Complete ophthalmologic examinations were scheduled pre-treatment, and at 1 d, 1 wk, 1, 3, 6 and 12 mo posttreatment. Primary outcomes were the IOP reduction and success rates at 12 mo, while the secondary outcomes were the occurrence of vision threatening complications and visual acuity.RESULTS: The records of 62 eyes of 62 patients were analyzed with mean age of 63.8 y(67.7% males). There was statistically significant reduction in the mean IOP from 35.2±8.3 mm Hg before treatment to 20.6±8.7 mm Hg at 12~(th) month(P<0.0005) with a mean percentage IOP reduction of 42.3% with significant reduction in the mean number of antiglaucomatous drugs from 3.2±0.4 before treatment to 2.1±1.02 at 12 mo(P<0.0005). Qualified success was achieved in 77.4% of eyes at 12 mo. No major intra-or posttreatment complications were reported.CONCLUSION: Second-generation UCP prove to be effective in reducing IOP in naive glaucoma patients with lower success rates in cases of neovascular and uveitic glaucomas.
引文
1 Fankhauser F,Kwasniewska S,Van der Zypen E.Cyclodestructive procedures.I.Clinical and morphological aspects:a review.Ophthalmologica2004;218(2):77-95.
    2 Iliev ME,Gerber S.Long-term outcome of trans-scleral diode laser cyclophotocoagulation in refractory glaucoma.Br J Ophthalmol2007;91(12):1631-1635.
    3 Coleman DJ,Lizzi FL,Driller J,Rosado AL,Burgess SE,Torpey JH,Smith ME,Silverman RH,Yablonski ME,Chang S.Therapeutic ultrasound in the treatment of glaucoma.II.Clinical applications.Ophthalmology 1985;92(3):347-353.
    4 Sterk CC,vd Valk PH,van Hees CL,van Delft JL,van Best JA,Oosterhuis JA.The effect of therapeutic ultrasound on the average of multiple intraocular pressures throughout the day in therapy-resistant glaucoma.Graefe’s Arch Clin Exp Ophthalmol 1989;227(1):36-38.
    5 Aptel F,Charrel T,Lafon C,Romano F,Chapelon JY,Blumen-Ohana E,Nordmann JP,Denis P.Miniaturized high-intensity focused ultrasound device in patients with glaucoma:a clinical pilot study.Invest Ophthalmol Vis Sci 2011;52(12):8747-8753.
    6 Mastropasqua R,Fasanella V,Mastropasqua A,Ciancaglini M,Agnifili L.High-intensity focused ultrasound circular cyclocoagulation in glaucoma:a step forward for cyclodestruction?J Ophthalmol 2017;2017:7136275.
    7 Melamed S,Goldenfeld M,Cotlear D.High-intensity focused ultrasound device in refractory Glaucoma patients.Results at 1 year.Invest Ophthalmol Vis Sci 2014;55(13):6171.
    8 Aptel F,Dupuy C,Rouland JF.Treatment of refractory open-angle glaucoma using ultrasonic circular cyclocoagulation:a prospective case series.Curr Med Res Opin 2014;30(8):1599-1605.
    9 Melamed S,Goldenfeld M,Cotlear D,Skaat A,Moroz I.High-intensity focused ultrasound treatment in refractory glaucoma patients:results at 1y of prospective clinical study.Eur J Ophthalmol 2015;25(6):483-489.
    10 Aptel F,Denis P,Rouland JF,Renard JP,Bron A.Multicenter clinical trial of high-intensity focused ultrasound treatment in glaucoma patients without previous filtering surgery.Acta Ophthalmol 2016;94(5):e268-e277.
    11 Giannaccare G,Sebastiani S,Campos EC.Ultrasound cyclo plasty in eyes with glaucoma.J Vis Exp 2018(131).
    12 Denis P,Aptel F,Rouland JF,Nordmann JP,Lachkar Y,Renard JP,Sellem E,Baudouin C,Bron A.Cyclocoagulation of the ciliary bodies by high-intensity focused ultrasound:a 12-month multicenter study.Invest Ophthalmol Vis Sci 2015;56(2):1089-1096.
    13 Deb-Joardar N,Reddy KP.Application of high intensity focused ultrasound for treatment of open-angle glaucoma in Indian patients.Indian J Ophthalmol 2018;66(4):517-523.
    14 Giannaccare G,Vagge A,Gizzi C,Bagnis A,Sebastiani S,Del Noce C,Fresina M,Traverso CE,Campos EC.High-intensity focused ultrasound treatment in patients with refractory glaucoma.Graefes Arch Clin Exp Ophthalmol 2017;255(3):599-605.
    15 Rouland JF,Aptel F.Primary open angle glaucoma treated by high intensity focused ultrasound(HIFU):results at 18mo of a prospective pilot study on patients treated with the 2nd generation probe.Acta Ophthalmol2016;94.
    16 Giannaccare G,Vagge A,Sebastiani S,Urbini LE,Corazza P,Pellegrini M,Carmassi L,Bergamini F,Traverso CE,Campos EC.Ultrasound cyclo-plasty in patients with glaucoma:1-year results from a multicentre prospective study.Ophthalmic Res 2018:1-6.
    17 Denis P.Clinical research of ultrasound ciliary plasty and implications for clinical practice.European Ophthalmic Review 2016;10(2):108.
    18 Aptel F,Rouland JF.Ultrasound ciliary plasty to treat glaucoma:efficacy and safety results on 152 patients.Acta Ophthalmol 2017;95.
    19 Aptel F,Rouland JF,Stalmans I,Denis P.Ultrasound treatment in patients with Primary Open-Angle Glaucoma with a second generation probe:Results of a Multicenter Clinical Trial.Acta Ophthalmol2016;94.
    20 Ramli N,Htoon HM,Ho CL,Aung T,Perera S.Risk factors for hypotony after transscleral diode cyclophotocoagulation.J Glaucoma2012;21(3):169-173.
    21 Pucci V,Tappainer F,Borin S,Bellucci R.Long-term follow-up after transscleral diode laser photocoagulation in refractory glaucoma.Ophthalmologica 2003;217(4):279-283.
    22 Graber M,Rothschild PR,Khoueir Z,Bluwol E,Benhatchi N,Lachkar Y.High intensity focused ultrasound cyclodestruction versus cyclodiode treatment of refractory glaucoma:a retrospective comparative study.J Fr Ophtalmol 2018;41(7):611-618.
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