Cathepsins mediate tumor metastasis

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英文篇名：Cathepsins mediate tumor metastasis 作者：Gong-Jun ; Tan ; Zheng-Ke ; Peng ; Jin-Ping ; Lu ; Fa-Qing ; Tang 英文作者：Gong-Jun Tan;Zheng-Ke Peng;Jin-Ping Lu;Fa-Qing Tang;Department of Clinical Laboratory, Xiangya Hospital, Central South University;Department of Clinical Laboratory, Zhuhai Hospital, Jinan of University; 英文关键词：Cathepsin;;Tumor;;Metastasis;;Mechanism 中文刊名：SJSW 英文刊名：世界生物化学杂志(电子版)(英文版) 机构：Department of Clinical Laboratory,Xiangya Hospital,Central South University;Department of Clinical Laboratory,Zhuhai Hospital,Jinan of University; 出版日期：2013-11-26 出版单位：World Journal of Biological Chemistry 年：2013 期：v.4 基金：Supported by National Natural Science Foundation of China,No.81071718,No.81000881,No.81372282 and No.30973400;; Fundamental Research Funds for the Central Universities,No.21611612;; Guangdong Natural Science Foundation,No.S2013010013360;; the Foundation of State Key Laboratory of Oncology in South China,No.HN2011-04 语种：英文; 页：SJSW201304003 页数：11 CN：04 分类号：20-30

摘要

Cathepsins are highly expressed in various human cancers, associated with tumor metastasis. It is superfamily, concluding A, B, C, D, E, F, G, H, L, K, O, S, V, and W family members. As a group of lysosomal proteinases or endopeptidases, each member has a different function, playing different roles in distinct tumorigenic processes such as proliferation, angiogenesis, metastasis, and invasion. Cathepsins belong to a diverse number of enzyme subtypes, including cysteine proteases, serine proteases and aspartic proteases. The contribution of cathepsins to invasion in human cancers is well documented, although the precise mechanisms by which cathepsins exert their effects are still not clear. In the present review, the role of cathepsin family members in cancer is discussed.
        Cathepsins are highly expressed in various human cancers, associated with tumor metastasis. It is superfamily, concluding A, B, C, D, E, F, G, H, L, K, O, S, V, and W family members. As a group of lysosomal proteinases or endopeptidases, each member has a different function, playing different roles in distinct tumorigenic processes such as proliferation, angiogenesis, metastasis, and invasion. Cathepsins belong to a diverse number of enzyme subtypes, including cysteine proteases, serine proteases and aspartic proteases. The contribution of cathepsins to invasion in human cancers is well documented, although the precise mechanisms by which cathepsins exert their effects are still not clear. In the present review, the role of cathepsin family members in cancer is discussed.

引文

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