摘要
糖尿病肾脏疾病(diabetic kidney disease,DKD)是糖尿病的重要合并症,是造成终末期肾病的重要原因,寻找早期预测肾功能损害的生物标志物具有重要临床意义。目前临床使用的DKD诊断的指标主要是尿白蛋白、肌酐、尿素氮等,但由于其特异度和灵敏度尚不理想,还需要进一步寻找DKD的早期诊断指标。多个研究表明尿触珠蛋白(haptoglobin,Hp)在早期DKD中可预测肾功能的进展,本文就Hp对早期糖尿病肾病患者肾功能损害的预测作用及相关机制进行综述。
Diabetic kidney disease is an important complication that occurs in some diabetes patients,and it is a leading cause of endstage renal disease. Biomarkers predicting the deterioration of renal function are important in clinical settings. Microalbuminuria,creatinine and urea nitrogen are widely used as markers to predict renal function decline,but the predictive value of these markers for kidney damage are limited. It is necessary to further search the indicators of diabetic kidney disease for early diagnosis. Several studies suggested that urine haptoglobin is a novel biomarker for predicting kidney damage in patients with diabetes. This article reviews the clinical significance and related mechanisms of the predictive value of haptoglobin on renal dysfunction in patients with early diabetic kidney disease.
引文
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