摘要
环状RNA作为非编码RNA家族中的新成员,具有作为微RNA海绵、调控亲本基因的表达、结合RNA结合蛋白、编码蛋白质等重要功能。近年来,随着对环状RNA研究的不断深入,其在诸多疾病发生发展过程中所发挥的重要作用被不断揭示,大多集中在肿瘤、神经系统疾病、动脉粥样硬化和糖尿病等方面。目前发现环状RNA在与包括肺结核、急性呼吸窘迫综合征、病毒性肺炎在内的肺部感染性疾病中差异表达,可能与环状RNA作为微RNA海绵来调节免疫反应、巨噬细胞极化以及诱导先天免疫基因表达等机制有关。这提示环状RNA在肺部感染性疾病的治疗干预方面提供了新的潜力并且可以作为诊断标志物。
Circular RNA is a new member of the non-coding RNA family,it functions as microRNA sponges,regulates gene transcription,binds to RNA-associated proteins and encodes protein,etc. In recent years,with more and more research available about circular RNA,it is accepted that circular RNA plays an integral role in the initiation and development of many diseases including neoplasm,atherosclerosis,diabetes and neurological diseases. It has been found that circular RNA expressed differentially in pulmonary infectious diseases including tuberculosis,acute respiratory distress syndrome,and viral pneumonia,which perhaps relates to the mechanism of circular RNA as microRNA sponges to regulate immune response,macrophage polarization,and induce the expression of innate immune gene,etc. Therefore,it hints that circular RNA has offered new opportunities for therapeutic intervention in pulmonary infectious diseases and might serve as a novel diagnostic in the near future.
引文
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