摘要
目的从海洋蓝细菌Okeania hirsuta中分离鉴定次级代谢产物并进行细胞毒活性评价。方法 3个天然产物(1～3)的结构确定是通过广泛的波谱数据,包括一维和二维核磁及质谱等。结果化合物3对人体肺癌细胞NCI-H460显示出强的细胞毒活性,IC50值为0.384μg/mL。结论这是首次从Okeania属蓝细菌中分离获得化合物1～3。这些天然产物的发现表明Okeania属蓝细菌可以作为发现新颖化合物的重要来源。
Objective To study the secondary metabolites of the marine cyanobacterium Okeania hirsuta and their cytotoxic activity.Methods The structures of the isolated three natural compounds(1～3)were identified by comprehensive spectroscopic data including ~1H NMR,~(13)C NMR,2D NMR and ESIMS.Results Compound 3 showed strong cytotoxic activity against human lung tumor cell line NCI-H460 with an IC50 value of 0.384μg/mL.Conclusion This is the first time to isolate these compounds from cyanobacteria of the genus Okeania.The discovery of these natural products suggests that the cyanobacterial genus Okeania would be a significant resource of structurally interesting molecules in the future.
引文
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