Effectiveness and safety of Shenmai injection in treatment of shock:a Meta-analysis

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英文篇名：Effectiveness and safety of Shenmai injection in treatment of shock:a Meta-analysis 作者：Li ; Xiaoli ; Shen ; Yi ; He ; Fan ; Zhu ; Yinchao ; Li ; Fudong 英文作者：Li Xiaoli;Shen Yi;He Fan;Zhu Yinchao;Li Fudong;Department of Gynecology,the Second Affiliated Hospital of Zhejiang University School of Medicine;Department of Epidemiology and Health Statistics,School of Public Health,Zhejiang University;Department of Public Health Surveillance and Advisory,Zhejiang Provincial Center for Disease Control and Prevention;Institute of Non-Communicable Disease Control and Prevention,Ningbo Municipal Center for Disease Control and Prevention; 英文关键词：Shock;;Meta-analysis;;Randomized controlled trial;;Shenmai injection 中文刊名：ZYYW 英文刊名：中医杂志(英文版) 机构：Department of Gynecology,the Second Affiliated Hospital of Zhejiang University School of Medicine;Department of Epidemiology and Health Statistics,School of Public Health,Zhejiang University;Department of Public Health Surveillance and Advisory,Zhejiang Provincial Center for Disease Control and Prevention;Institute of Non-Communicable Disease Control and Prevention,Ningbo Municipal Center for Disease Control and Prevention; 出版日期：2018-04-15 出版单位：Journal of Traditional Chinese Medicine 年：2018 期：v.38 基金：Supported by the Program for Zhejiang Leading Team of Science and Technology Innovation(No.2011R50021);; Medical Research Program of Zhejiang Province(No.2015RCB011) 语种：英文; 页：ZYYW201802001 页数：12 CN：02 ISSN：11-2167/R 分类号：5-16

摘要

OBJECTIVE:To evaluate the effectiveness and safety of Shenmai injection for shock.METHODS: Randomized controlled trials(RCTs)that evaluated the therapeutic effect of Shenmai injection on shock(including septic shock, cardiogenic shock, hypovolemic shock, neurogenic shock and anaphylactic shock) were included in this analysis. The major electronic databases were searched until May 2015. The methodological quality of the trials was assessed according to the Cochrane Handbook. Review Manager 5.3 and Stata 12.0 software were applied for data analysis.RESULTS: Thirty RCTs involving 2038 participants were included. The methodological quality of the trials was generally passable. The combined use of Shenmai injection and conventional medicine was significantly more effective at managing shock compared to conventional medicine alone in the outcomes of total effective rate [risk ratio(RR 1.25,95% confidence interval(CI) 1.18 to 1.31] and mortality rate [risk difference(RD)-0.10, 95% CI-0.17 to-0.02]. Likewise, improvements were observed in other metrics. Three trials reported adverse events, but no trial reported serious adverse effects.CONCLUSION: Our results indicated the potential effectiveness of Shenmai injection combined with conventional medicine treatment for shock. However, further rigorously designed trials are needed to collect and weigh up all the evidence for the use of Shenmai injection.
        OBJECTIVE:To evaluate the effectiveness and safety of Shenmai injection for shock.METHODS: Randomized controlled trials(RCTs)that evaluated the therapeutic effect of Shenmai injection on shock(including septic shock, cardiogenic shock, hypovolemic shock, neurogenic shock and anaphylactic shock) were included in this analysis. The major electronic databases were searched until May 2015. The methodological quality of the trials was assessed according to the Cochrane Handbook. Review Manager 5.3 and Stata 12.0 software were applied for data analysis.RESULTS: Thirty RCTs involving 2038 participants were included. The methodological quality of the trials was generally passable. The combined use of Shenmai injection and conventional medicine was significantly more effective at managing shock compared to conventional medicine alone in the outcomes of total effective rate [risk ratio(RR 1.25,95% confidence interval(CI) 1.18 to 1.31] and mortality rate [risk difference(RD)-0.10, 95% CI-0.17 to-0.02]. Likewise, improvements were observed in other metrics. Three trials reported adverse events, but no trial reported serious adverse effects.CONCLUSION: Our results indicated the potential effectiveness of Shenmai injection combined with conventional medicine treatment for shock. However, further rigorously designed trials are needed to collect and weigh up all the evidence for the use of Shenmai injection.

引文

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