Vitellaria paradoxa nutshells from seven sub-Saharan countries as potential herbal medicines for treating diabetes based on chemical compositions, HPLC fingerprints and bioactivity evaluation

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英文篇名：Vitellaria paradoxa nutshells from seven sub-Saharan countries as potential herbal medicines for treating diabetes based on chemical compositions, HPLC fingerprints and bioactivity evaluation 作者：LI ; Da ; XIAO ; Jian-Qi ; LIU ; Wen-Yuan ; ZHANG ; Chao-Feng ; AKIHISA ; Toshihiro ; ABE ; Masahiko ; MASTERS ; Eliot-T. ; ZHAI ; Wei-Wei ; FENG ; Feng ; ZHANG ; Jie 英文作者：LI Da;XIAO Jian-Qi;LIU Wen-Yuan;ZHANG Chao-Feng;AKIHISA Toshihiro;ABE Masahiko;MASTERS Eliot-T.;ZHAI Wei-Wei;FENG Feng;ZHANG Jie;Jiangsu Food and Pharmaceutical Science College;Department of Pharmaceutical Analysis, China Pharmaceutical University;Research Institute for Science and Technology, Tokyo University of Science;World Agroforestry Centre (ICRAF), Nelson Marlbolough Institute of Technology (NMIT);School of Traditional Chinese Pharmacy, China Pharmaceutical University;Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University; 英文关键词：Vitellaria paradoxa;;HPLC fingerprints;;Antioxidant activity;;α-Glucosidase inhibitory activity;;Molecular docking 中文刊名：ZGTR 英文刊名：中国天然药物(英文版) 机构：Jiangsu Food and Pharmaceutical Science College;Department of Pharmaceutical Analysis, China Pharmaceutical University;Research Institute for Science and Technology, Tokyo University of Science;World Agroforestry Centre (ICRAF), Nelson Marlbolough Institute of Technology (NMIT);School of Traditional Chinese Pharmacy, China Pharmaceutical University;Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University; 出版日期：2019-06-20 出版单位：Chinese Journal of Natural Medicines 年：2019 期：v.17 基金：supported by the General Program Foundation of Jiangsu Food and Pharmaceutical Science College(No.JSFP·2018005-Z);; the Natural Science Foundation of Jiangsu Province(No.BK20170742);; the Youth Science Fund Project of National Natural Science Foundation of China(No.81703383) 语种：英文; 页：ZGTR201906005 页数：15 CN：06 ISSN：32-1845/R 分类号：54-68

摘要

The aim of the study was to determine the feasibility of the Vitellaria paradoxa nutshell as a new medicinal resource for treating diabetes. A total of forty-one compounds were identified by HPLC-DAD-Q-TOF-MS and phytochemical methods in V. paradoxa nutshell methanol extract. Based on HPLC fingerprints, four characteristic constituents were quantified and the origin of twenty-eight V. paradoxa nutshells from seven sub-Saharan countries was compared, which were classified into three groups with chemometric method. Twenty-eight samples contained high total phenolic content, and exhibited moderate-higher antioxidant activity and strong α-glucosidase inhibitory activity. Furthermore, all fractions and isolated compounds were evaluated for their antioxidant and α-glucosidase inhibitory activities, and α-glucosidase inhibitory action mechanism of four characteristic constituents including protocatechuic acid, 3, 5, 7-trihydroxycoumarin,(2 R, 3 R)-(+)-taxifolin and quercetin was investigated via molecular docking method, which were all stabilized by hydrogen bonds with α-glucosidase. The study provided an effective approach to waste utilization of V. paradoxa nutshell, which would help to resolve waste environmental pollution and provide a basis for developing potential herbal resource for treating diabetes.
        The aim of the study was to determine the feasibility of the Vitellaria paradoxa nutshell as a new medicinal resource for treating diabetes. A total of forty-one compounds were identified by HPLC-DAD-Q-TOF-MS and phytochemical methods in V. paradoxa nutshell methanol extract. Based on HPLC fingerprints, four characteristic constituents were quantified and the origin of twenty-eight V. paradoxa nutshells from seven sub-Saharan countries was compared, which were classified into three groups with chemometric method. Twenty-eight samples contained high total phenolic content, and exhibited moderate-higher antioxidant activity and strong α-glucosidase inhibitory activity. Furthermore, all fractions and isolated compounds were evaluated for their antioxidant and α-glucosidase inhibitory activities, and α-glucosidase inhibitory action mechanism of four characteristic constituents including protocatechuic acid, 3, 5, 7-trihydroxycoumarin,(2 R, 3 R)-(+)-taxifolin and quercetin was investigated via molecular docking method, which were all stabilized by hydrogen bonds with α-glucosidase. The study provided an effective approach to waste utilization of V. paradoxa nutshell, which would help to resolve waste environmental pollution and provide a basis for developing potential herbal resource for treating diabetes.

引文

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