摘要
黏液表皮样癌为唾液腺常见的恶性肿瘤,其发病率位居我国口腔颌面部恶性肿瘤的第3位,具有侵袭性强、转移率高、预后差、治疗困难的特点。随着分子生物技术的高速发展,基因靶点治疗成为一种治疗新思路,因此探索黏液表皮样癌生物学特性及预后评估的相关分子标志物成为研究热点。本文就近年来黏液表皮样癌的分子标志物研究进展进行综述,为今后该病的研究及治疗提供依据。
引文
[1]Conroy T,Hebbar M,Bennouna J,et al.Quality-of-life findings from a randomized phase-iii study of xelox vs.folfox-6in metastaic colorectal cancer[J].Br J Cancer,2010,102(1):59-67.
[2]Iourgenko V,Zhang W,Mickanin C,et al.Identification of a family of c AMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells[J].Proc Natl Acad Sci U S A,2003,100(21):12 147-12 152.
[3]Tonon G,Modi S,Wu L,et al.t(11;19)(q21;p13)translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a notch signaling pathway[J].Nat Genet,2003,33(2):208-213.
[4]Wu L,Liu J,Gao P,et al.Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREBactivation[J].EMBO J,2005,24(13):2 391-2 402.
[5]Clauditz TS,Gontarewicz A,Wang CJ,et al.11q21 rearrangement is a frequent and highly specific genetic alteration in mucoepidermoid carcinoma[J].Diagn Mol Pathol,2012,21(3):134-137.
[6]Kang H,Tan M,Bishop JA,et al.Whole-Exome Sequencing of Salivary Gland Mucoepidermoid Carcinoma[J].Clin Cancer Res,2017,23(1):283-288.
[7]Seethala RR,Dacic S,Cieply K,et al.A reappraisal of the MECT1/MAML2 translocation in salivary mucoepidermoidcarcinomas[J].Am J Surg Pathol,2010,34(8):1 106-1 121.
[8]Bell D,El-Naggar AK.Molecular heterogeneity in mucoepidermoid carcinoma:conceptual and practical implications[J].Head Neck Pathol,2013,7(1):23-27.
[9]Saade RE,Bell D,Garcia J,et al.Role of CRTC1/MAML2translocation in the prognosis and clinical outcomes of mucoepidermoid carcinoma[J].JAMA Otolaryngol Head Neck Surg,2016,142(3):234-240.
[10]Sen R,Baltimore D.Multiple nuclear factors interact with the immunoglobulin enhancer sequences[J].Cell,1986,46(5):705-716.
[11]Zhang YH,Yan HQ,Wang F,et al.TIPE2 inhibits TNF-α-induced hepatocellular carcinoma cell metastasis via Erk1/2downregulation and NF-κB activation[J].Int J Oncol,2015,46(1):254-264.
[12]Takada Y,Kobayashi Y,Aggarwal BB.Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting Ikappa Balpha kinase activation,thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression,up-regulating apoptosis,and inhibiting invasion[J].J Biol Chem,2005,280(17):17 203-17 212.
[13]边国新,李松英.黏液表皮样癌中NF-κB和COX-2表达的相关性研究[J].浙江医学,2007,29(7):648-649.
[14]宁兆荣,李松,郭延伟,等.环氧化酶2、X染色体连锁凋亡抑制蛋白在唾液腺恶性肿瘤中的表达及意义[J].上海口腔医学,2014,23(3):317-321.
[15]Marguardt JU,Gomez-Quiroz L,Arreguin Camacho LO,et al.Curcumin effectively inhibits oncogenic NF-κB signaling and restrains stemness features in liver cancer[J].J Hepatol,2015,63(3):661-669.
[16]袁倩,吴发印,周鹤峰,等.姜黄素联合5-氟尿嘧啶对黏液表皮样癌细胞的增殖抑制和促凋亡作用及其机制[J].广西医学,2018,40(8):939-943.
[17]Katoh I,Aisaki KI,Kurata SI,et al.p51A(TAp63garama)a p53 homolog,accumulates in response to DNA damage for cell regulation[J].Oncogene,2000,19(27):3 126-3 130.
[18]Tsai MR,Shieh DB,Lou PJ,et al.Characterization of oral squamous cell carcinoma based on higher-harmonic Generation microscopy[J].J Biophotonics,2012,5(5/6):415-424.
[19]Senoo M,Pinto F,Crum CP,et al.p63 is essential for the proliferative potential of stem cells in stratified epithelia[J].Cell,2007,129(3):523-536.
[20]Rokudai S,Li Y,Otaka Y,et al.STXBP4 regulates APC/C-mediated p63 turnover and drives squamous cell carcinogenesis[J].Proc Natl Acad Sci U S A,2018,115(21):E4 806-E4 814.
[21]Foschini MP,Gaiba A,Cocchi R,et al.p63 expression in salivary gland tumors:role of Delta Np73L in neoplastic transformation[J].Int J Surg Pathol,2005,13(4):329-335.
[22]Di Como CJ,Urist MJ,Babayan I,et al.p63 expression profiles in human normal and tumor tissues[J].Clin Cancer Res,2002(8):494-501.
[23]Edwards PC,Bhuiya T,Kelsch RD,et al.Assessment of p63expression in the salivary gland neoplasms adenoid cystic carcinoma,polymorphous low-grade adenocarcinoma,and basal cell and canalicular adenomasl[J].Oral Surg Oral Med O-ral Pathol Oral Radiol Endod,2004,97(5):613-619.
[24]Sams RN,Gnepp DR.P63 expression can be used in differential diagnosis of salivary gland acinic cell and mucoepidermoid carcinoma[J].Head Neck Pathol,2013,7(1):64-68.
[25]闫欢芳,李卫星,齐鸿亮.34βe12和P63在涎腺黏液表皮样癌中的表达研究[J].中国药物与临床,2015,15(4):478-480.
[26]Hendrix MJ,Seftor EA,Meltzer PS,et al.Expression and functional significance of VE-cadherin in aggressive human melanoma cells:Role in vasculogenic mimicry[J].Proc Natl Acad Sci U S A,2001,98(14):8 018-8 023.
[27]Fry SA,Sinclair J,Timms JF,et al.A targeted glycoproteomic approach identifies cadherin-5 as a novel biomarker of metastatic breast cancer[J].Cancer Lett.2013,328(2):335-344.
[28]Azzi S,Hebda JK,Gavard J.Vascular permeability and drug delivery in cancers[J].Front Oncol,2013,3:211.
[29]Irani S,Dehghan A.The expression and functional significance of vascular endothelial-cadherin,CD44,and vimentin in oral squamous cell carcinoma[J].J Int Soc Prev Community Dent,2018,8(2):110-117.
[30]Maniotis AJ,Folberg R,Hess A,et al.Vascular channel formation by human melanoma cells in vivo and in vitro:vasculogenic mimicry[J].Am J Pathol,1999,155(3):739-752.
[31]Liu SY,Chang LC,Pan LF,et al.Clinicopathologic significance of tumor cell-lined vessel and microenvironment in oral squamous cell carcinoma[J].Oral Oncol,2008,44(3):277-285.
[32]Wang W,Lin P,Han C,et al.Vasculogenic mimicry contributes to lymph node metastasis of laryngeal squamous cell carcinoma[J].J Exp Clin Cancer Res,2010,29:60.
[33]Sun B,Zhang S,Zhang D,et al.Vasculogenic mimicry is associated with high tumor grade,invasion and metastasis,and short survival in patients with hepatocellular carcinoma[J].Oncol Rep,2006,16(4):693-698.
[34]安琦,南欣荣,赵志刚,等.bcl-2表达与腮腺黏液表皮样癌病理组织学分级临床分期的相关性研究[J].中国医药指南,2016,10(17):455-457.
[35]Irani S,Dehghan A.Expression of vascular endothelial-cadherin in mucoepidermoid carcinoma:role in cancer development[J].J Int Soc Prev Community Dent,2017,7(6):301-307.
