摘要
目的:检测环氧化酶2(Cox-2)与X染色体连锁凋亡抑制蛋白(XIAP)在唾液腺腺样囊性癌(ACC)与黏液表皮样癌(MEC)中的表达,探讨两者在唾液腺恶性肿瘤发生、发展中的作用及相关性。方法:采用免疫组织化学SP法检测95例唾液腺恶性肿瘤(包括50例ACC、45例MEC)、10例多形性腺瘤及10例正常唾液腺组织中Cox-2和XIAP的表达情况,使用SPSS17.0软件包对数据进行统计学处理。结果:Cox-2、XIAP在唾液腺恶性肿瘤中高表达,在多形性腺瘤和正常唾液腺组织中不表达或低表达。Cox-2、XIAP的表达与唾液腺恶性肿瘤组织临床分期和远处转移呈正相关(P<0.05),而与肿瘤部位无相关性(P>0.05)。结论:Cox-2和XIAP在唾液腺恶性肿瘤中高表达,可能在唾液腺恶性肿瘤发生、发展过程中具有重要作用。
PURPOSE:To detect the expression of Cox-2 and XIAP in adenoid cystic carcinoma(ACC) and mucoepidermoid carcinoma(MEC) of salivary glands.To study the role and correlation between the expression of Cox-2and XIAP in malignant tumors of salivary gland.METHODS:Immunohistochemical SP staining method was used to quantify the protein expression levels of Cox-2 and XIAP in 95 patients with malignant tumors of the salivary gland(50ACCs,45 MECs),10 patients with pleomorphic adenoma and 10 persons with normal salivary gland tissues.SPSS17.0software package was used to analyze the data.RESULTS:Cox-2 and XIAP were expressed strongly in malignant tumors of the salivary gland,while they not expressed in pleomorphic adenoma and normal salivary gland tissues.The expression of Cox-2 and XIAP in malignant tumors of salivary gland was correlated with clinical stage and lymphnode metastasis,while they not correlated with primary sites(P >0.05).CONCLUSIONS:The high expression of Cox-2 and XIAP in malignant tumors of salivary gland may play an important role in the development of malignant tumors of the salivary gland.
引文
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