摘要
X染色体连锁凋亡抑制蛋白(XIAP)是凋亡抑制蛋白(IAPs)家族中的重要一员,其主要由N末端3个杆状病毒IAP重复序列(BIR)和C末端一个锌指结构域组成,其主要通过与caspase相互作用抑制细胞凋亡,此外XIAP还可通过核因子κB途径和参与信号转导途径抑制细胞凋亡。XIAP的正向调节主要是在翻译过程中实现的,而负向调节则主要由Smac、转化生长因子β信号通路中的凋亡相关蛋白、HtrA、XIAP相关因子1凋亡抑制蛋白1等XIAP抑制分子实现。XIAP与肿瘤治疗研究方面,反义寡核苷酸技术、XIAP小分子抑制剂、RNA干扰技术等为治疗肿瘤提供了新的研究方向。
XIAP(X-linked inhibitor of apoptosis protein) is one of the most important members of IAPs family.It mainly includes three N-terminal baculoviral IAP repeat(BIR) sequences and a C-terminal zinc finger domain.It inhibits cell apoptosis mainly by inhibiting the caspases protein,and also through nuclear factor kappa B(nuclear factor kappa B NF-κB) pathway and signal transduction pathways.Positive regulation of XIAP is mainly achieved in the process of translation,while negative regulation of XIAP is mainly through XIAP inhibitors such as Smac,ARTS,HtrA and XAF1.Antisense oligonucleotide technology,XIAP small molecule inhibitors,RNA interference technology has provided a new research direction for the treatment of tumors.
引文
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