摘要
背景:鹿茸是唯一能够周期性再生的复杂哺乳动物器官,其再生过程是基于干细胞的存在。研究鹿茸再生机制,探索干细胞在哺乳动物器官再生中的作用对于再生生物学和再生医学研究具有重要的意义。目的:综述鹿茸再生研究,干细胞及相关因子在鹿茸再生中的作用。方法:应用计算机检索1994-01/2012-10 PubMed数据库(http://www.ncbi.nlm.nih.gov/PubMed)。检索词为:deer antler;antler regeneration;stem cell,并限定文章语言种类为English。此外还手动查阅相关专著数部。结果与结论:共检索文献87篇,最终纳入文献31篇。决定鹿茸发生及再生的关键组织分别为生茸区骨膜和角柄骨膜,这两种组织中的细胞被定义为鹿茸干细胞。鹿茸干细胞上覆盖的皮肤组织构成了这些干细胞活动所需的特定微环境。多种细胞因子IGF、性激素、EGF、VEGF等参与了鹿茸再生及快速生长调控。探索鹿茸干细胞微环境内各组分间相互作用所需的信号因子、阐明其调控机制,对了解鹿茸再生之谜,对于揭示干细胞在哺乳动物器官再生的作用具有十分重要的意义。
BACKGROUND:Deer antlers are the unique mammalian organs which can periodically regenerate,the process was known as stem cell-based.Exploring the underlying mechanism of deer antler regeneration and indentifying the functional role of stem cell in mammalian organ regeneration was of great importance to regenerative biology and regenerative medicine.OBJECTIVE:To review the relevant literatures of the research progress in antler regeneration、antler stem cells and antler cytokines.METHODS:A Computer-based online search of PubMed(1994-01/2012-10) was performed for acquiring the articles in English by using the key words "deer antler;antler regeneration;stem cell.In addition,manual search was also performed for those literatures that cannot be readily obtained from internet search..REAULTS AND CONLUSION:A total of 87 articles were obtained and finally31 articles were selected.The key tissue types for antler regeneration were antlerogenic periosteum(AP) and pedicle periosteum(PP),the cells within which are known as antler stem cells.The covering skin of AP and PP constitutes the functional niche for antler stem cells.Numerous cytokines are involved in the process of antler fast growing and full regeneration,including IGF,sex hormones,EGF,VEGF etc.It is vitally important to identify the interacting molecules between the antler stem cells and their niche cell types,and to define the role of each molecule plays in antler regeneration,which will greatly advance our understanding of the stem cell-based mammalian organ regeneration.
引文
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