摘要
包封无机纳米粒(INPs)的高分子微球兼具INPs的光、磁、影像等特性和高分子载体的稳定性和生物相容性等,可用作可控的药物释放载体和自显影介入栓塞材料等。但常用的制备方法繁琐、INPs在微球中分布不均、微球的形貌和粒径不可控,由此影响了其生物医用效果。我们采用液滴型微流控技术,将INPs制备前体与聚合物前体溶液预先均匀混合后作为水相,在微流控装置的微通道或接收液中同时完成纳米粒的制备和微球的凝胶化,一步得到包封原位形成的INPs的聚合物微球。因高分子链的模板作用和采用了均相的制备前体,所制得的INPs在微球中均匀分布,其含量还可通过改变INPs制备前体的用量来调控。另外,调控微流控的油水两相的流速及其比值,可很好地控制微球的粒径。所制备的微球粒径均一,作为肿瘤的介入治疗用栓塞微球时,除栓塞作用外,还具有光/热触发的药物释放、热疗、术中和术后自显影等功能。本文将介绍所制备的原位包封BaSO_4、Au、Fe_3O_4/Ga_2O_3等纳米粒的海藻酸盐微球和PVA微球的特性及其生物医用。
Polymeric microspheres encapsulated with inorganic nanoparticles(INPs) have fascinating applications in biomedicine due to the combined advantages of INPs and polymers. Using droplets-based microfluidic technique, we have prepared various INPs@polymeric microspheres for trans-catheter arterial embolization by one step. These in-situ synthesized INPs were dispersed homogenously inside the microspheres and the content of INPs in microspheres might be adjusted easily. In addition, the size of the microspheres could be controlled by changing the ratio of the flow rates of the used oil phase and aqueous phase in the microfluidic device. As embolic agent, these obtained hybrid microspheres possess additional properties, such as inherent CT or MR-visuality, magnetism, photothermal effect or controllable drug release behaviour, etc.
引文
[1]Wang,Q.;Qian,K.;Liu,S.S.;Yang,Y.J.,Liang,B.;Zheng,C.S.;Yang,X.L.;Xu,H.B.;Shen,A.Q.Biomacromolecules,2015,16(4):1240.
[2]Wang,Q.;Zhang,D.;Yang,X.L.;Xu,H.B.;Shen,A.Q.;Yang,Y.J.Green Chem,2013,15(8):2222.
[3]Wang,Q.;Zhang,D.;Xu,H.B.;Yang,X.L.;Shen,A.Q.;Yang,Y.J.Lab chip,2012,12(22):4781.
