摘要
目前,丘脑底核(subthalamic nucleus,STN)脑深部电刺激(deep brain stimulation,DBS)疗法已经成为治疗中晚期帕帕金森病(Parkinson’s disease, PD)的一项安全而有效的方法,并且在临床中的应用越来越广泛,具有良好的疗效,其具有手术安全性高、术后并发症较少、病人耐受性较好等优点,但是有关STN的DBS作用机制尚不清楚。本研究通过对猴偏侧PD模型STN核给予长期高频电刺激(high frequency stimulation HFS),使用微透析及高效液相分析技术观察纹状体区细胞外液中谷氨酸(Glu)、γ-氨基丁酸(γ-GABA)、牛磺酸(Tau)等氨基酸类神经递质的变化。结果提示长期的STN HFS可以升高猴偏侧PD模型纹状体谷氨酸(Glu)和牛磺酸(Tau)的含量,同时降低了γ-氨基丁酸(γ-GABA)的含量。
Deep brain stimulation of subthalamic nucleus (STN DBS) is a safe and effective treatment for patients with Parkinson’s disease (PD).But the mechanism of STN DBS remained to be answered. We observed changes of extracellular glutamate, gamma-aminobutyric acid and taurine in the corpus striatum of MPTP-induced hemiparkinsonian monkeys after long term chronic high frequency stimulation of STN. The results indicated that the senior monkey PD models after long term high frequency stimulation, the content of extracellular glutmate and taurine in the corpus striatum of stimulated side increased while the gamma-aminobutyric acid decreased significantly. The study showed that the levels of extracellular glutmate and tautine in the corpus striatum of hemiparkinsonism rhesus monkeys can be increaseed , while gamma-aminobutyric acid decreased by STN HFS, and this may play a very important role in the mechanism of STN HFS.
引文
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