摘要
目的:1、探讨运用凉血化瘀法治疗系统性红斑狼疮瘀热痹阻证的临床疗效;2、评价该治疗方法是否对单纯运用强的松+环磷酰胺有减毒增效作用;3、为临床治疗系统性红斑狼疮瘀热痹阻证提供依据。
方法:搜集符合要求的病例40例,按照随机对照的原则,将40例患者分为治疗组和对照组。两组病人均符合系统性红斑狼疮的诊断标准。治疗组在常规西医治疗的基础上,配合运用具有凉血化瘀作用的中药治疗,对照组使用常规西药治疗,观察两组病例中患者入院治疗前及治疗3个月后临床症状,体征及相关实验室检查如:血白细胞、血小板、血红蛋白,尿蛋白,抗ds-DNA,抗SSA抗体、抗SSB抗体、抗Sm抗体,补体C3、C4,24h尿蛋白定量,ESR,C反应蛋白,肝。肾功能等。资料均采用SPSS14.0软件进行统计分析。
结果:1.治疗组的疾病疗效评定总有效率高于对照组,但差异无统计学意义(p＞0.05);2.治疗组对照组SLEDAI评分和中医证候积分在治疗后较治疗前均有明显改善(P＜0.01),并且治疗组降低较对照组明显,有统计学差异(P＜0.05);3.治疗后两组补体C3、C4均较治疗前上升,具有统计学差异(P均＜0.01),治疗组补体C3较对照组升高明显(P＜0.05);治疗后两组CRP、ESR较治疗前降低,但治疗组CRP较对照组降低明显,具有统计学差异(P均＜0.05),治疗组IgG治疗后较对照组治疗后降低较为明显,具有统计学差异(P＜0.05);4.治疗组治疗前后24小时尿蛋白定量明显低于对照组,但无显著性差异(P＞0.05);5.两组治疗后抗ds-DNA抗体的阳性例数均较治疗前有减少(P均＜0.05),但两组治疗后无差异(P均＞0.05);各组抗SSA抗体、抗SSB抗体、抗Sm抗体治疗前后均无显著差异(P均＞0.05)。
结论:常规西医治疗的同时,结合中医凉血化瘀法辨证论治SLE瘀热痹阻证能提高疗效,改善临床症状,控制SLE活动,降低蛋白尿及减少副作用。中西医结合治疗组疗效更好,本研究为临床治疗瘀热痹阻证SLE提供了一定的参考依据。
Objective: 1.To explored in the method of cooling blood and promoting blood flow of drugs in the treatment of stagnated heat and blockage card of systemic lupus erythematosus; 2.The evaluation of the treatment methods used for simple MP + cyclophosphamide are attenuated synergies; 3.For the treatment of stagnated heat and blockage card of systemic lupus erythematosus provide the basis for stasis.
Methods: Collected to meet the requirements of a total of 40 cases of cases,in accordance with the principle of stochastic control,40 cases were divided into treatment and control groups. Patient groups are in line with the diagnostic criteria for stagnated heat and blockage card of systemic lupus erythematosus. In the conventional treatment group on the basis of traditional Chinese and western medicine treatment with the use of cooling blood and promoting blood flow role of the traditional Chinese medicine treatment, the control group using conventional western medicine treatment,patients were observed in patients hospitalized for treatment before and three months after the clinical symptoms and signs and the related laboratory tests such as: white blood cell, platelet, hemoglobin, urine protein, anti-ds-DNA, anti-SSA antibody, anti-SSB antibodies, anti-Sm antibodies, complement C3, C4, 24h urinary protein, ESR, C-reactive protein, liver and kidney function. Information SPSS14.0 software used for statistical analysis. Results: 1. The treatment group effect of the disease have assessed the overall efficiency of the control group, but the difference was not statistically significant (p> 0.05); 2. The treatment group and control group SLEDAI score and traditional Chinese medicine symptoms score before treatment than after treatment are significantly improved (P <0.01), and the treatment group significantly lower than the control group, there is significant difference (P <0.05); 3. Treated the two groups complement C3, C4 were increased before treatment, with significant difference (P all <0.01), the treatment group's C3 complement increased significantly than the control group's (P <0.05); after treatment the two groups CRP, ESR lower than before treatment, but treatment group's CRP significantly lower than the control group, with significant difference (P all < 0.05). After treatment treatment group's IgG reduce the more obvious than the control group, with significant difference (P <0.05); 4. The 24-hour urinary protein of the treatment group was significantly lower than the control group before and after the treatment, but no significant difference (P> 0.05 ); 5. After treatment the number of positive cases of two groups of anti-ds-DNA antibodies has reduced than pre-treatment (P all <0.05), however, no difference in the two groups after treatment (P all> 0.05); the group of anti-SSA antibody, anti-SSB antibodies, anti-Sm antibodies before and after treatment there was no significant difference (P all> 0.05).
Conclusion: Western medicine treatment combined with cooling blood and promoting blood flow of drugs in the treatment of stagnated heat and blockage card of systemic lupus erythematosus can improve the clinical symptoms, control SLE activity, reduce proteinuria and reduce side effects. The effect of Traditional Chinese combined with western medicine was better, and this study for clinical treatment of stagnated heat and blockage card of systemic lupus erythematosus provides a frame of reference.
引文
[1]熊琼春.中西医治疗系统性红斑狼疮[J].河南中医,2006,26(2):37-38.
[2]北京中医医院.赵炳南临床经验集[M].北京:人民卫生出版社,1975.260.
[3]徐俊良.系统性红斑狼疮中医辨治旨要[J].江苏中医药,2007,39(6):56-57.
[4]刘士敬,郭明.肾脏风毒与SLE[J].辽宁中医杂志,1998,25(1):13-14.
[5]赵智强,周仲瑛.从阳毒辨治红斑狼疮[J].中医药学报,1998,4:18-19.
[6]金实,朱方石,叶霜,等.补肾化毒法治疗SLE的理论机制探讨[J].南京中医药大学学报(自然科学版).2002,18(1):5-7.
[7]苏晓,沈丕安.沈丕安教授治疗系统性红斑狼疮的经验[J].新中医.1998,30(8):10-11.
[8]曹慧芬,林丽,孟如.孟如教授治疗系统性红斑狼疮的经验[J].云南中医中药杂志,1999,20(5):1-3.
[9]孙凤琴.凉血解毒除湿散瘀法治疗系统性红斑狼疮急性皮肤损害的体会[J].中医杂志,1995,36(8):484.
[10]魏睦新,沈友轩.活血化瘀疗法在系统性红斑狼疮治疗中的运用[J].中医研究.2001,8,14(4):35-36.
[11]陈湘君.系统性红斑狼疮的辨施治证[J].辽宁中医杂志,1987(4):15.
[12]樊莹.周仲瑛治疗系统性红斑狼疮的经验[J].中医杂志,1997,38(11):658-659.
[13]曹惠芳.孟如教授治疗SLE的经验[J].云南中医中药杂志,1999,20(5):1-3.
[14]时水治.袁兆庄治疗系统性红斑狼疮的经验[J].北京中医,2004,23(6):332.
[15]陈会茹,李振杰.艾儒棣治疗系统性红斑狼疮的经验[J].浙江中医杂志,2003,(2):51-52.
[16]时水治,李建生.辨证论治配合金龙胶囊治疗系统性红斑狼疮33例临床观察[J].北京中医,2002,19(3):34-35.
[17]魏睦新.系统性红斑狼疮的中医证治规律探讨[J].云南中医中药杂志,2001,22(4):8.
[18]卢桂玲.边天羽诊治系统性红斑狼疮经验[J].中国中西医结合皮肤性病学杂志,2003,2(1):1-4.
[19]汪悦.风湿病中医治疗[M].南京:江苏科学技术出版社,2005.305-307.
[20]董熔,王蔼平,陈爱林.中西医结合治疗系统性红斑狼疮24例[J].陕西中医,2001,22(9):515-516.
[21]顾美华,陈志伟,邓迎苏.中西医结合治疗系统性红斑狼疮54例临床观察[J].江苏中医药,2002,23(4):22-23.
[22]黄荣璋,唐玉.中西医结合治疗系统性红斑狼疮22例[J].福建医药杂志.2000,22(2):113-114.
[23]范永升.中医药治疗系统性红斑狼疮的探讨[J].浙江中医杂志,2002,37(5):200-201.
[24]张志礼,安家丰,刘矗,等.中西医结合治疗系统性红斑狼疮[J].中华皮肤科杂志,1996,29(1):64-65.
[25]李相有,方敬爱,叶任高.中西医结合治疗重症狼疮性肾炎128例[J].中国医刊,2000,35(6): 46-47.
[26]查旭山,范瑞强,郧国维教授.中西医结合治疗系统性红斑狼疮32例[J].新中医,2001,33(8):31-32.
[27]赵团结,于黎.SLE分型辨治体会[J].河南中医,1999,19(6):16-17.
[28]方福根.中西医结合治疗18例系统性红斑狼疮临床分析[J].江西中医药.1999,30(6):41.
[29]林丽,曹惠芬.滋肾养阴益气法治疗系统性红斑狼疮93例[J].河北中医.1999,21(2):82.
[30]王萍,张凡,张志礼.张志礼治疗系统性红斑狼疮经验[J].北京中医,1999,18(2):5.
[31]史俊萍,史宝印.分型辨治红斑狼疮的经验体会[J].辽宁中医杂志.1998,25(4):165.
[32]苏晓,沈丕安.沈丕安教授治疗系统性红斑狼疮的经验[J].新中医.1998,30(8):10.
[33]杨利,金实,汪悦.狼疮静对活动性5CD患者血清sIL-2R、TNF-a的影响[J].中国中医药信息杂志,2000,7(9):34-35.
[34]陈会茹,李振杰.艾儒棣治疗系统性红斑狼疮的经验[J].浙江中医杂志,2003,(2):51-52.
[35]谢锐龙,徐伟,李晓昊,等.清瘟败毒饮加减治疗系统性红斑狼疮活动期合并贫血临床观察[J].中国中医急症,2004,13(11):736-737.
[36]林丽,曹惠芬.滋肾养阴益气法治疗系统性红斑狼疮93例[J].河北中医,1999,21(2):85-84.
[37]钟嘉熙.苓丹片治疗SLE149例[J].新中医,1997,29(11):12-14.
[38]刁金山.燥湿祛瘀法治疗SLE的临床研究[J].河南中医,1995,15(2):88-91.
[39]王宏亮,汪英华.祛风温阳通络法论治系统性红斑狼疮32例临床观察[J].中国中医药科技.1998,5(5):313.
[40]周德荣.清透血毒法治疗系统性红斑狼疮疗效观察[J].北京中医.1998,17(1):39.
[41]苏晓,沈丕安.红斑汤治疗系统性红斑狼疮82例[J].中国中医药科技,1998;5(3):178.
[42]卢晓文,张义生,王劲红.中西医结合治疗系统性红斑狼疮70例报告[J].贵阳中医学院学报.1998,20(4):18.
[43]睦书魁,高建华,马秀清,等.狼疮饮治疗系统性红斑狼疮的临床研究[J].河北中医.2000,22(2):85.
[44]徐再春,胡岗,蒋惠芳,等.圣惠大青丸治疗系统性红斑狼疮中度活动43例[J].辽宁中医学院学报,2000,2(1):25-26.
[45]郑少平,王行宽.化斑解毒饮治疗系统性红斑狼疮热毒炽盛证的临床研究[J].中国中医药科技.2000,7(1):3.
[46]方福根.中西医结合治疗18例系统性红斑狼疮临床分析[J].江西中医药.1999,30(6):41.
[47]顾军花,陈湘君.复方自身清免疫调节作用的动物实验研究[J].上海中医药大学学报,2001,15(2):44.
[48]王松珍.补肾消斑汤加减治疗SLE[J].河南中医,1996,16(4):225-227.
[49]周锦.狼疮性肾炎中西医结合的诊断及治疗[J].浙江中医学院学报,2001,25(3):27.
[50]李玉堂,刘学耀.中西医结合治疗难治性狼疮性肾炎18例[J].湖北中医杂志,2001,23(7):19.
[51]叶任高,阳晓.狼疮性肾炎尿毒症可逆性及其治疗[J].中国中西医结合肾病杂志,2001,2(1):1.
[52]杜秀兰,刘英,孙素平,等.抗狼疮散治疗系统性红斑狼疮[J].山东中医药大学学报,2000,24(5):354.
[53]郑少平,王行宽.化斑解毒饮治疗系统性红斑狼疮热毒炽盛证的临床研究[J].中国中医药科技.2000,7(1):3-5.
[54]王宏亮,汪英华.祛风温阳通络法为主治疗系统性红斑狼疮32例[J].上海中医药杂志,2000,34(5):21.
[55]李祖光.用药百宝箱一重用升麻解毒[J].台湾:新医药周刊,2000,18(12):184.3.
[56]刘思明.中西医结合治疗增生型狼疮肾炎38例临床观察[J].浙江中西医结合杂志,2002,12(3):141-143.
[57]陆双军.醒脑静注射液治疗红斑狼疮22例临床体会[J].安徽中医临床杂志,2002,14(1):12-13.
[58]张庆冶.雷公藤多甙应用于肾脏病治疗的一些体会[J].肾脏病与透析肾移植杂志,2003,12(3):248.
[59]黎磊石,刘志红.应用雷公藤治疗肾炎二十五载的体会[J].肾脏病与透析肾移植杂志,2003,12(3):246-247.
[60]孙联文,郑家润,陈法,等.环孢素A、雷公藤内酯醇及红霉素与5-酯氧合酶产物的关系[J].中华皮肤科杂志,2001,34(2):110-111.
[61]吴曙光.抗炎免疫药理学进展[M].上海:第二军医大学出版社,1997.162.
[62]帅宗文,徐建华,魏伟,等.白芍总苷治疗系统性红斑狼疮的初步探讨[J].中华风湿病学杂志,2004,8(7):441.
[63]赵鹏,李彬,何为涛,等.三七皂苷对小鼠免疫功能影响的实验研究[J].中国热带医学,2004,4(4):52.
[64]江源,刘翠,陈清彬,等.三七皂苷Rg1对小鼠免疫功能的影响[J].中国现代医药.2006,8(3):9-11.
[65]陈刚,刘润伙,陈喜玲.丹参对pZ—GPI诱导的白身免疫小鼠aCL产生的影响[J].西安医科人学学报,2001,22(5):429-431.
[66]胡仲仪,唐利群,陈以平等.益气活血系列方对膜性肾炎模型基底膜影响的实验研究[J].中国中西医结合杂志,1999,19(2):96-99.
[67]方晓力,龙晓英.白花蛇舌草成分、药理和临床应用概况[J].中药材料,1996,19(3):152-153.
[68]张国强,叶任高,孔庆瑜,等.丹参对培养中狼疮性肾炎成纤维细胞的影响[J].中国医药学报,1997,12(1):19.
[69]朱方石,金实,汪悦,等.狼疮静颗粒对狼疮样小鼠外周血CD4+、CD8+及CD54表达的影响[J].中药新药与临床药理,2003,14(3):165-168.
[70]朱方石,金实,丁炜.狼疮静对NZB/NZWF1小鼠病情发展的动态观察[J].浙江中医杂志,2003,1:28-29.
[71][陈湘君,周时高,苏励,等.滋阴解毒法为主对SLE免疫紊乱调节作用的研究[J].辽宁中医杂志, 1995,22(6):257.
[72]范永升,贺学林,温成平.解毒祛癖滋阴煎剂对系统性红斑狼疮样小鼠的作用研究[J].中国医药学报.1999;14(2):34.
[73]梁鸣,李幼姬,阳晓,等.中药狼疮方对狼疮样小鼠脾细胞体外分泌白细胞介素-6和白细胞介素-10的影响[J].中国中西医结合杂志,2002,22(5):372-375.
[74]李非,白雪源,陈香美,等.利用基因芯片探讨中药复方对MRL/Ipr狼疮小鼠肾脏基因表达及TH1/TH2细胞的调节作用[J].中国中西医结合杂志,2003,23(3):198-200.
[75]屈毅文,罗文辉.补肾活血方合激素治疗系统性红斑狼疮临床疗效及对免疫功能的影响[J].中国中医药信息杂志,2004,11(3):246-247.
[76]顾军华,陈湘君,苏励.复方“自身清”对活动性系统性红斑狼疮患者T细胞亚群的作用[J].浙江中医学院学报,2001,25(3):26.
[77]许晨,吴兆龙.雷公藤红素防治狼疮性肾炎肾小球硬化的研究[J].中国中西医结合肾病杂志,2002,3(3):132.
[78]温成平,范永升,黄永凯,等.中药狼疮定对系统性红斑狼疮外周微循环影响的研究[J].中国中西医结合肾病杂志,2002,3(12):704.
[79]范永升,温成平,谷焕鹏,等.解毒祛瘀滋阴法对系统性红斑狼疮患者血液流变学的影响[J].中医杂志,1999,40(6):348.
[80]金若敏,陈长勋,犀角与水牛角药理作用的研究[J].中成药1997,19(7),33-34,497-498.
[81]汪华林,叶任高,李幼姬,等.川芎嗪对活动期LN对外周血单个核细胞B7-1和B7-mRNA表达的影响[J].中国中西医结合肾病杂志,2001,2(5):262.
[82]张国强,叶任高,孔庆瑜,等.丹参对LN成纤维细胞增殖,凋亡及c-myc蛋白表达的影响[J].中西医结合杂志,1997,17(8):473.
[83]王海颖.陈以平教授治疗LN的经验[J].新中医,2001,33(9):9.
[84]王映坤.系统性红斑狼疮中西医药和西药疗效对比观察[J].中国中西医结合杂志,1997,17(10):624.
[85]张剑勇,钟嘉熙,彭胜权,等.苓丹片,青蒿琥酯对系统性红斑狼疮患者IL-2与SIL-2R影响研究[J].河南中医学院,2003,2(18):38.
[86]宁英远,王检勤,屈遂林.大黄素对人肾成纤维细胞增殖的影响[J].中国中西医结合杂志,2000,20(2):105-106.
[87]刘冠贤,叶任高,谭志明,等.大黄素对狼疮性肾炎成纤维细胞生物学行为的影响[J].中国中西医结合杂志,2000,20(3):196.
[88]冯俊志,赵国平.当归的免疫药理研究进展[J].福建中医药,2003,34(3):49-51.
[89]何山,马佐英.丹参药理作用研究进展[M].继续医学教育,2003,17(3):39-42.
[90]凌庆枝,敖宗华,尹光耀,等.地黄的研究概况[J].淮南师范学院学报.,2003,5(3):21-23.
[91]赵守讯,黄泰康,丁志遵,等主编.紫草.中药辞海(第三卷)[M].北京:中国医药科技出版社, 1997.831-839.
[92]中华医学会风湿病学分会.系统性红斑狼疮诊治指南(2003年)[J].现代实用医学 2003,15(12).
[93]Arnett FC.Genetic aspects of human Lupus.Clin Immunol Immunopathol,1992,63:4.
[94]Walport MJDavies KA,Botto M.Clq and systemic lupus erythematosus.Immunobiology,1998,199:265.
[95]Schur PH.Genetics of systemic lupus erythematosus.Lupus,199,4:425.
[96]Salmon JE,millard S,Schachter LA,et al.Fc gamma R Ⅱ A alleles are heritable risk factors for lupus nephritis in African Americans.J Clin Invest,1996,97:1348.
[97]Sanchez-Guerrero J,Liang MH,Karlson EW,etal.Postmenopausal estrogen therapy and the risk for developing systemic lupus erythematosus.Ann Intem Med,1995,122:430.
[98]Petri M.Exogenous estrogen in systemic lupus erythematosus:oarl contraceptives and hormone replacement therapy.Lupus,2001,10:222.
[99]Steinbery AD.Gourley MF.Klinman DM,et al.stystemic Lupus erythematosus.Ann Intern Med,1991,115:548.
[100][Berden JH,Lich R,van BruggenMC,etal.Role of nucleosomes for induction and glomerular binding of antoantibodies in luptts nephritis[J].Curr Opin Nephrol Hypertens,1999,8(3):299.
[101]Sturfele G Bengtsson A,Klint C,etal.Novel roles of complement in systemic lupus erythematosus-hypothesis of a pathogenetic vicious circle[J].J R heumatol,2000,27(3):661.
[102]刘锐,刘钢.狼疮性肾炎的诊治[J].华西医学,2007,22(2):447-448.
[103]蒋元武,陈俊智,张磊.系统性红斑狼疮治疗研究进展[J].实用药物与临床,2006,9(4):255-256.
[104]GoldblattF,IsenbergDA.New therapies for systemic lupus erythematosus[J].Clinical and Experimental Immunology,2005,140:205-212.
[105]李军平.来氟米特治疗狼疮性肾炎21例疗效观察[J].苏州大学学报(医学版),2007,27(2):282-284.
[106]Tam LS,Li EK,Wong CK,et al.Safety and efficacy of leflunomide in the treatment of lupus nephritis refractory or intolerant to traditional immunosuppressive therapy:an open label trial[J].Ann Rheum Dis,2006,65(3):417-416.
[107]崔太根,侯凡凡,倪兆慧,等.来氟米特联合皮质激素治疗增殖型狼疮性肾炎的多中心对照临床试验研究[J].中华肾脏病杂志,2005,44(9):672-676.
[108]吗替麦考酚酯在肾内科应用专家协作组.吗替麦考酚酯在肾内科应用的指导意见[J].中华肾脏病杂志,2004,20(5):385.
[109]刘玉春,赵明辉,邹万忠,等.普乐可复治疗弥漫增殖性狼疮肾炎5例临床病理观察[J].中国实用内科杂志,2004,24(3):175-176.
[110]Takabayashi K,Koike T,Kurasawa K,et al.Effect of FK-506,a novel immunosuppressive drug on murine systemic lupus erythematosus[J].Clin Immunol Immunopathol,1989,51(1):110-117.
[111]Kanekura T,Yoshii N.Terasaki KEfficacy of topical tacrolimus for treating the malar rash of systemic lupus erythematosus[J].Br J Dermatol,2003,148(2):353-356.
[112]Mok CC,Tong KH,To CH,et al.Tacrolimus for induction therapy of diffuse proliferative lupus nephritis:an openlabeled pilot study[J].Kidney Int,2005,68(2):813-817.
[113]Mosca M,Baldini C,Bombardieri S,et al.LJP-394(abetimus sodium) in the treatment of systemic lupus erythematosus[J].Expert Opin Pharmacother,2007,8(6):873-879.
[114]Furie RA,Cash JM,Cronin ME,et al.Treatment of systemic lupus erythematosus with LJP 394[J].Rheumatol,2001,28(2):257-265.
[115]Linnik MD,Hu JZ,Heilbrunn KR,et al.Relationship between anti-double-stranded DNA antibodies and exacerbation of renal disease in patients with systemic lupus erythematosus[J].Arthritis Rheum,2005,52(4):1129-1137.
[116]BOUMPASL,DIMITRIOST,SIDROPOULOSF,etal.Optimumtherapeutic approaches for lupus nephritis:what therapy and fowhom?[J].NatClin PractRh,2005,1(1):22-30.
[117]Lazurova I,Macejova Z,Benhatchi K,et al.Efficacy of intravenous immunoglobulin treatment in lupus erythematosus chorea[J].Clin Rheumatol,2006,295(5):527-535.
[118]Lazurova I,Macejova Z.Benhatchi KEfficacy of intravenous immunoglobulin treatment in lupus erythematosus chorea[J].Clin Rheumatol,2007,295(5):527-535.
[119]张志坚,胡红霞.血浆置换辅助治疗自身免疫性疾病的临床观察[J].宁夏学杂志,2005,27(12):853-854.
[120][美]路迪.凯利风湿病学[M].左晓霞,陶立坚,高洁生译.第7版.北京:人民卫生出版社,2006:1060.
[121]Kapoor S,Wilson AG,Sharrack B,et al.Haemopoietic temcelltransplantation anevolvingtreatmentfor severe autoimmune and inflammatory diseases in rheumatology,neurology and gastroenterology[J].Hematology,2007,12(3):179-191.
[122]徐景勃,侯丽君,何志国,等.非清髓性自体外周血造血干细胞移植治疗系统性红斑狼疮的临床观察[J].中华风湿病学杂志,2007,11(1):31-33.
[123]Hochberg M C.Updating the American College of Rheumatology revised criteria for the classification of SLE[J].ArthritisRheum,1997,40:1725-1730.
[124]庞鹤,王晓梅.醒脑健神丹合清开灵注射液治疗急性脑出血的实验研究[J].中国中医急症 1995,4(2)69-71.
[125]段景文,彭建国.大黄止血合剂治疗急性上消化道出血64例[J].中国中医急症,2005,14(9):895-896.
[126]金庆丰.大黄酚制剂用于创面止血[J].中医杂志,1992,42(1):5-6.
[127]王道芳.浅述桃仁与苦杏仁的药理及临床应用[J].基层用药杂志,2002,16(6):61.
[128]赵守讯,黄泰康,丁志遵,等,主编.紫草.中药辞海(第二卷)[M].北京:中国医药科技出版社,1997.831-839.
[129]杨荣.6种紫草的药理活性比较[J].中国医药学报,1992,7(3):34.
[130]凌庆枝,敖宗华,尹光耀,等.地黄的研究概况[J].淮南师范学院学报,2003,5(3):21-23.
[131]国家中医药管理局《中华本草》编委会.中华本草[M].上海:上海科技出版社 1998:1739.
[132]Li Yiming,Zeng Huawu,He Xiang,et al.Iridoid and phenylpropanoid glycosides of Scrophularia ningpoensis inhibit the formation of LTB4 and platelet aggregation[J].Acad J Sec Mil Med Univ,1999,20(5):301-303.
[133]倪正,蔡雪珠,黄一平,等.玄参提取物对大鼠血液流变性、凝固性和纤溶活性的影响[J].中国微循环,2004,8(5):339.
[134]王璟.解毒祛斑汤治疗系统性红斑狼疮的实验研究[A].南京中医药大学2006年同等学力人员申请硕士学位论文,2006:32-34.
[135]冯玉环,石颜军.中药的抗炎免疫抑制作用[J].实用医学杂志,1996,12(11):769.
