摘要
目的:探讨清开灵注射液(简称清开灵)治疗活动期类
风湿性关节炎(RA)的机理。方法:将70例确诊为类风湿性关节
炎的患者随机分为清开灵治疗组38例,火把花根片对照组32例,对
其症状、体征及实验室检查作治疗前后对比。采用Ⅱ型胶原免疫
Wister大鼠诱发的关节炎模型(CIA),观察清开灵对CIA大鼠足肿
胀的影响及关节病理的变化;并观察了其对大白兔的退热作用、对
小鼠纸片肉芽肿的影响和镇痛的作用。结果:临床治疗组总有效率
为89.47%,对照组总有效率为87.5%,两组总有效率比较差异不显
著(P>0.05)。但在退热方面,清开灵组明显优于火把花根片组
(P<0.01)。动物实验表明清开灵具有解热、抗炎、镇痛、免疫调
节作用。组织病理学改变示滑膜组织增生及炎症细胞浸润程度较模
型组减轻。结论:清开灵可用于活动期类风湿性关节炎的治疗。
Objective: To explore the mechanism of Qingkailing injection
(QKLI) in treating rheumatiod arthritis(RA) in active stage.
Methods: Seventy cases of RA in active stage were divided into the
treated group (38 cases treated with QKLI) and the control group(32
cases treated with HuoBaHuaGen tablet). The syptonis-. signs and
laboratory examinations of all patients before and after treatment were
observed. In experiment study,severity of arthritis and the arthritic index
were investigated in the wister rats with collagen-induced arthritis (CIA)
and in mice. In addition, observation of antifebric effect on rabbits was
also made.Results: The total effective rate was 89.47 % in treatment
group,while in control group,it was 87.5 %. The difference of total
effective rate between the two groups was unremarkable (P>O.05), while
QKLI is superior to HuoBafluaGen tablet in effect of antifebric.
Experiments on animals showed QKLI has the function of antifebric~
dephlogisticate -~ anigesia and immune regulation. I[Iistopthology
showed that less synovium hyperplasia and fewer infiltration of
inflammatory cells in the group treated with QKLI than the control
group. Conclusion:QKLI can be applied to the therapy of RA in. active
stage.
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