摘要
近年来,纳米技术在电分析化学领域成为了备受瞩目的热点话题。由于它具有相当小的粒径,展现出独特的化学,物理和电学性质故而被广泛的应用于多种分析方法。本论文主要是将纳米技术与电化学分析技术相结合,研制了以电沉积铂、金纳米粒子修饰电极为基础的具有高灵敏度、高选择性的维生素药物分子传感器。论文主要包括五章:
前言:主要是综述了纳米材料的性质和研究,尤其是贵金属纳米粒子的性质及应用;同时也探讨了化学修饰电极的制备、碳纳米管和石墨烯的性质及其修饰电极在电分析化学领域的应用。
第二章:我们通过电沉积的方法将铂纳米粒子沉积在多壁碳纳米管修饰的玻碳电极表面,用于研究芦丁(rutin)的电化学性质,并成功的应用于市售复方芦丁片中芦丁含量的测定,效果良好,灵敏度较高。
第三章:我们利用多壁碳纳米管的良好特性并通过电沉积的方法将金纳米粒子沉积在多壁碳纳米管修饰的玻碳电极表面,用于研究维生素B_6(VB_6)的电化学性质,并成功的应用于市售维生素B_6片及注射液中维生素B_6含量的测定,检测准确,且灵敏度较高。
第四章:我们将金纳米粒子通过电沉积的方式沉积在多壁碳纳米管修饰的玻碳电极表面,用于研究维生素B_2(VB_2)的电化学性质,该实验操作简单,耗时短,且效果良好。
第五章:我们利用石墨烯的良好的性能并将金纳米粒子电沉积在功能化的石墨烯修饰的玻碳电极表面,用于研究VB_6的电化学性质,实验结果比较理想,并有望用于实际样品的检测。
This dissertation focus on fully utilizing the unique characteristics of nano-materials and modern electrochemical technology conclude electrodepostion to prepare several novel small biomolecules electrochemical biosensors, developing sensitive, selective detection methods. The dissertation includes four chapters:
Chapter 1 introduces the properties and research of nano-materials and the preparation of nanometer materials modified electrodes. A review is given on the electrochemical study of platinum and gold nanoparticles biosensors, including their importance and development. Puting forward the idea of this paper.
Chapter 2: platinum nanoparticles (Pt NPs) were electrodeposited on the surface of MWCNTs modified glassy carbon electrode (GCE). Then the prepared electrode was applied for the determination of rutin. In addition, the Pt NPs / MWCNTs modified electrode had been applied to the determination of rutin in real samples.
Chapter 3: gold nanoparticles (Au NPs) were electrodeposited on the surface of MWCNTs modified GCE. Then the Au NPs / MWCNTs modified electrode had been successfully applied for the determination of vitamin B_6 (VB_6). And the Au NPs / MWCNTs modified electrode had been applied to the determination of VB_6 in real samples.
Chapter 4: Au NPs were electrodeposited on the surface of MWCNTs modified GCE. Then the prepared electrode was applied for the determination of vitamin B_2 (VB_2). It exhibited excellent voltammetric response for VB_2.
Chapter 5: Au NPs were electrodeposited on the surface of graphene modified GCE by electrodeposition. Then the prepared electrode was applied for the determination of VB_6. The experimental results are good, and the prepared electrodes are expected to be applied to real sample examination.
引文
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