摘要
目的:探讨以纤维蛋白复合脱蛋白松质骨作为骨形态发生蛋白(BMP)的载体修复兔节段性骨缺损。材料和方法:于36只青紫蓝兔两侧桡骨干处造成1.5cm缺损,采用三种方法进行处理:A组,植入脱蛋白松质骨、纤维蛋白、BMp的复合物;B组,植入脱蛋白松质骨;C组,空白对照。术后2、4、8、12、16周进行放射学、组织学和电镜检查。结果:A组骨缺损区在成骨活跃程度、骨再生量和再生髓腔结构等方面均显著优于B组,使骨缺损得到了较彻底的修复。B、C两组均不能产生骨性愈合。结论:脱蛋白松质骨复合纤维蛋白是较理想的BMP载体材料,以三者的复合物修复骨缺损可达到满意效果。
A Experimental Study of the Efficacy of a deproteinised cancellous bone combined with BMP and fibrinin Healing of Rabbit Segmental Radial Defect//Deng Gang, Liu Xing-yan,Chen Ke-ming,Bai Meng-hai,Zhang Xu-yuan et al.Clinical Medical College of LanZhou University,Lanzhou 730000.
Abstract Purpose:To repair segmental bone defect with the composite of deproteinised cancellousbone,bone morphogenetic protein(BMP)andfibrin.Methods:Bone defects were createdin 36 New Zealand rabbits on the bilateral Radius and were treated with three kinds of implantations:A,Composites of deproteinised cancellous bone,BMP and fibrin;B,deproteinised cancellousbone;C,nothings control.The defects were observed through entgenograph,opticalmicroscopeobserving, electronmicroscope scanning,at 2,4,8,12,16 weeks.Results:The defects treat with A implantation regenerated much more new bone and bridged earlier than the defects treated with B implantation and were repaired satisfyingly 16 weeks after operation.The defects with B and C implantation couldn't get osseous tissue healing. Conclusion:The composites of deproteinised cancellousbone,bone morphogenetic protein(BMP)and fibrin can be used effectively to repair segmental bone defect.
引文
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