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Elsevier电子期刊(1579)
在“
Elsevier电子期刊
”中,
命中:
1,579
条,耗时:小于0.01 秒
在所有数据库中总计命中:
1,579
条
1.
Total coumarins of Hedyotis diffusa induces apoptosis of myelodysplastic syndrome SKM-1 cells by activation of caspases and inhibition of PI3K/Akt pathway proteins
作者:
Jianping Jiang
a
;
b
;
1
;
Bo Wang
a
;
1
;
Jing Li
a
;
Baodong Ye
a
;
Shengyun Lin
a
;
lsyww2012@163.com
;
Wenbin Qian
c
;
Letian Shan
b
;
letian.shan@hotmail.com
;
Thomas Efferth
d
关键词:
AIF
;
apoptosis-inducing factor
;
AML
;
acute myeloid leukemia
;
CA
;
p-coumaric acid
;
DMSO
;
dimethyl sulfoxide
;
ECL
;
enhanced chemiluminescence kit
;
E-CSME
;
E-6-O-p-coumaroyl scandoside methyl ester
;
FBS
;
fetal bovine serum
;
HDW
;
Hedyotis diffusa Willd
;
HSCT
;
hematopoietic stem cell transplantation
;
IC50
;
50% inhibitory concentration
;
LSD
;
least significant difference
;
MAPK
;
mitogen-activated protein kinase
;
MDS
;
myelodysplastic syndromes
;
MTT
;
3-(4
;
5-dimethylthiazol-2-yl)-2
;
5-diphenyltetrazolium br
刊名:Journal of Ethnopharmacology
出版年:2017
2.
Inhibition kinetics and molecular simulation of p-substituted cinnamic acid derivatives on tyrosinase
作者:
Yi Cui
a
;
Yong-Hua Hu
a
;
Feng Yu
a
;
Jing Zheng
a
;
Lin-Shan Chen
a
;
Qing-Xi Chen
a
;
b
;
Qin Wang
a
;
qwang@xmu.edu.cn
关键词:
4-CCA
;
4-chlorocinnamic acid
;
4-ECA
;
4-ethoxycinnamic acid
;
4-NCA
;
4-nitrocinnamic acid
;
DMSO
;
dimethyl-sulfoxide
;
L-Tyr
;
L-tyrosine
;
L-DOPA
;
L-3
;
4-Dihydroxyphenylalanine
;
Km
;
Michaelis-Menten constant
;
KI
;
equilibrium constant of the inhibitor combining with the free enzyme
;
IC50
;
inhibitor concentration leading to a 50% loss of activity
刊名:International Journal of Biological Macromolecules
出版年:2017
3.
A matrix-focused structure-activity and binding site flexibility study of quinolinol inhibitors of botulinum neurotoxin serotype A
作者:
William A. Harrell Jr.
a
;
d
;
Rebecca C. Vieira
a
;
e
;
Susan M. Ensel
b
;
Vicki Montgomery
a
;
Rebecca Guernieri
a
;
Vanessa S. Eccard
a
;
f
;
Yvette Campbell
a
;
Virginia Roxas-Duncan
a
;
g
;
John H. Cardellina II
a
;
h
;
Robert P. Webb
a
;
robert.p.webb6.civ@mail.mil
;
Leonard A. Smith
c
关键词:
BoNTs
;
botulinum neurotoxins
;
BoNT/A
;
botulinum neurotoxin serotype A
;
HC
;
heavy chain
;
LC
;
light chain
;
SNARE
;
soluble N-ethylmaleimide-sensitive factor attachment protein receptor
;
SNAP-25
;
25
;
kDa synaptosomal-associated protein
;
BIG-IV
;
Botulism Immune Globulin Intravenous (Human)
;
SAR
;
structure-activity relationship
;
IC50
;
50% inhibitory concentration
;
MPNHDA
;
mouse phrenic nerve hemidiaphragm assay
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2017
4.
Synthesis and characterization of novel, conjugated, fluorescent DNJ derivatives for α-glucosidase recognition
作者:
Akihiko Hatano
a
;
a-hatano@sic.shibaura-it.ac.jp
;
Yuichi Kanno
a
;
Yuya Kondo
a
;
Yuta Sunaga
a
;
Hatsumi Umezawa
a
;
Munehiro Okada
a
;
Hideshi Yamada
a
;
Ren Iwaki
b
;
Atsushi Kato
b
;
Koji Fukui
c
关键词:
Inhibitor
;
α-Glucosidase
;
DNJ-fluorescent conjugate
;
Docking simulation
;
IC50
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
5.
Metabolic profile and β-glucuronidase inhibitory property of three species of Swertia
作者:
Swagata Karak
;
Gargi Nag
;
Bratati De
;
bdbot@caluniv.ac.in
关键词:
Swertia
;
β-Glucuronidase
;
Xanthones
;
Hepatoprotective
刊名:Revista Brasileira de Farmacognosia
出版年:2017
6.
Synthesis, characterization, in vitro SAR and in vivo evaluation of N,N′bisnaphthylmethyl 2-alkyl substituted imidazolium salts against NSCLC
作者:
Michael A. DeBord
a
;
Marie R. Southerland
a
;
Patrick O. Wagers
a
;
Kristin M. Tiemann
b
;
Nikki K. Robishaw
a
;
Kyle T. Whiddon
a
;
Michael C. Konopka
a
;
Claire A. Tessier
a
;
Leah P. Shriver
a
;
c
;
Sailaja Paruchuri
a
;
David A. Hunstad
b
;
Matthew J. Panzner
a
;
;
Wiley J. Youngs
a
;
youngs@uakron.edu
关键词:
NCI
;
National Cancer Institute
;
IC50
;
inhibitory concentration 50%
;
NSCLC
;
non-small cell lung cancer
;
IC23
;
4
;
5-dichloro-1
;
3-bis(naphthalen-2-ylmethyl)imidazolium bromide
;
MTT
;
3-(4
;
5-dimethylthiazol-2-yl)-2
;
5-diphenyltetrazolium bromide
;
CD
;
cyclodextrin
;
2-HPβCD
;
2-hydroxypropyl-β-cyclodextrin
;
FDA
;
Food and Drug Administration
;
PS
;
phosphatidylserine
;
PI
;
propidium iodide
;
FID
;
fluorescent interacalator displacement
;
CT-DNA
;
calf thymus DNA
;
DTP
;
Developmental Therapeutics Program
;
IP
;
intra
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2017
7.
N-Acetyl-chitobiose ameliorates metabolism dysfunction through Erk/p38 MAPK and histone H3 phosphorylation in type 2 diabetes mice
作者:
Xia Wu
a
;
Jing Wang
b
;
Yuqin Shi
b
;
Sai Chen
a
;
Qiaojuan Yan
a
;
Zhengqiang Jiang
b
;
zhqjiang@cau.edu.cn
;
Hao Jing
b
关键词:
ALX
;
alloxan
;
COS
;
chitooligosaccharide
;
Erk
;
extracellular signal-regulated kinase
;
(GlcNAc)2
;
N-acetyl-chitobiose (PubChem CID
;
160244)
;
H&E
;
haematoxylin and eosin
;
HOMA-IR
;
homeostasis model assessment of insulin resistance
;
IC50
;
the 50% inhibitory concentration
;
IL-1β
;
interleukin-1 beta
;
JNK
;
c-Jun terminal kinase
;
MAPK
;
mitogen-activated protein kinase
;
MDA
;
malondialdehyde
;
MKK
;
MAPK kinases
;
MSK
;
mitogen and stress activated protein kinase
;
NF-κB
;
nuclear factor-kappaB
;
SOD
;
superoxide
刊名:Journal of Functional Foods
出版年:2017
8.
Chiral resolution of serial potent and selective σ
1
ligands and biological evaluation of (−)-[
18
F]TZ3108 in rodent and the nonhuman primate brain
作者:
Xuyi Yue
a
;
Hongjun Jin
a
;
Zonghua Luo
a
;
Hui Liu
a
;
Xiang Zhang
a
;
Ethan D. McSpadden
b
;
Linlin Tian
c
;
Hubert P. Flores
c
;
Joel S. Perlmutter
a
;
c
;
Stanley M. Parsons
b
;
Zhude Tu
a
;
tuz@mir.wustl.edu
关键词:
calcd
;
calculated
;
CH2Cl2
;
dichloromethane
;
CNS
;
central nervous system
;
DMSO
;
dimethyl sulfoxide
;
[3H]DTG
;
[3H]ditolylguanidine
;
DTTA
;
di-p-toluoyl tartaric acid
;
EBP
;
emopamil binding protein
;
ee
;
enantiomeric excess
;
EOB
;
end of bombardment
;
EtOH
;
ethanol
;
[18F]FTC146
;
18F-6-(3-fluoropropyl)-3-(2-(azepan-1-yl)ethyl)benzo[d]thiazol-2(3H)-one
;
HPLC
;
high performance liquid chromatography
;
HRMS
;
high resolution mass spectrometry
;
IC50
;
half maximum inhibitory constant
;
K2CO3
;
potassium carbonate
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
9.
Efficacy and safety of “Yahom” as a traditional Thai herbal therapy: A systematic review
作者:
Krongkarn Chootip
a
;
Nathorn Chaiyakunapruk
b
;
c
;
d
;
e
;
f
;
h
;
Noppamas Soonthornchareonnon
g
;
C. Norman Scholfield
b
;
h
;
Anjana Fuangchan
b
;
anjanaf@nu.ac.th
关键词:
2-AA
;
2-aminoanthracene
;
Ach
;
Acetylcholine
;
AF2
;
2-aminofluorene
;
Aq
;
Aqueous
;
BMI
;
Body mass index
;
BP
;
Blood pressure
;
BUN
;
Blood urea nitrogen
;
CYPs
;
Cytochromes P450
;
DBP
;
Diastolic blood pressure
;
DPPH
;
2
;
2-diphenyl-1-picrylhydrazyl
;
ECG
;
Electrocardiogram
;
FRAP assay
;
Ferric reducing antioxidant power assay
;
HPLC
;
High Performance Liquid Chromatography
;
HR
;
Heart rate
;
IC50
;
Inhibitory concentration that cause 50% inhibition
;
ID50
;
Inhibitory dose that cause 50% inhibition
;
IP
;
Intraperit
刊名:Journal of Ethnopharmacology
出版年:2017
10.
Interaction of nonionic detergents with the specific sites of lysozyme amyloidogenic region − inhibition of amyloid fibrillization
作者:
Katarina Siposova
a
;
katkasiposova@gmail.com
;
siposova@saske.sk
;
Tibor Kozar
b
;
Andrey Musatov
a
关键词:
CMC
;
critical micelle concentration
;
DDM
;
n-dodecyl-β-d-maltoside
;
DH
;
hydrodynamic diameter of micelles
;
HEWL
;
hen egg white lysozyme
;
IC50
;
half-maximal inhibitory concentration
;
ThT
;
thioflavin T
;
TX-100
;
Triton X-100
刊名:Colloids and Surfaces B: Biointerfaces
出版年:2017
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