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在“
Elsevier电子期刊
”中,
命中:
22,347
条,耗时:0.0669688 秒
在所有数据库中总计命中:
31,076
条
1.
The noni anthraquinone damnacanthal is a multi-
kinase
inhibitor
with potent anti-angiogenic effects
作者:
Javier A. Garcí
;
a-Vilas
a
;
b
;
Almudena Pino-Á
;
ngeles
c
;
Beatriz Martí
;
nez-Poveda
a
;
b
;
Ana R. Quesada
a
;
b
;
d
;
Miguel Á
;
ngel Medina
a
;
b
;
d
;
medina@uma.es
关键词:
Damnacanthal
;
Noni
;
Morinda citrifolia
;
Angiogenesis
;
Multi-
kinase
inhibitor
刊名:Cancer Letters
出版年:2017
2.
Macrocyclic MEK1/2
inhibitor
with efficacy in a mouse model of cardiomyopathy caused by lamin A/C gene mutation
作者:
Wei Wu
a
;
b
;
Mahendra D. Chordia
c
;
g
;
Barry P. Hart
d
;
E. Sathyajith Kumarasinghe
c
;
Min K. Ji
c
;
Ajay Bhargava
e
;
Michael W. Lawlor
f
;
Ji-Yeon Shin
a
;
b
;
Fusako Sera
a
;
Shunichi Homma
a
;
Antoine Muchir
a
;
b
;
h
;
Uday R. Khire
c
;
d
;
ukhire@allomek.com
;
Howard J. Worman
a
;
b
;
hjw14@columbia.edu
关键词:
Cardiomyopathy
;
Emery-Dreifuss muscular dystrophy
;
Extracellular signal-regulated
kinase
;
Lamin
;
MEK
inhibitor
;
Mitogen-activated protein
kinase
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
3.
Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein
kinase
inhibitor
作者:
Lyamin Z. Bendjeddou
a
;
b
;
Nadè
;
ge Loaë
;
c
a
;
Benoî
;
t Villiers
a
;
Eric Prina
c
;
Gerald F. Spä
;
th
c
;
Hervé
;
Galons
b
;
Laurent Meijer
a
;
meijer@manros-therapeutics.com
;
Nassima Oumata
a
;
oumata@manros-therapeutics.com
关键词:
Kinase
inhibitor
;
Imidazo[1
;
2-b]pyridazine
;
Unicellular parasites
;
Leishmania
;
DYRK1A
;
CLKs
刊名:European Journal of Medicinal Chemistry
出版年:2017
4.
Identification of a novel 5-amino-3-(5-cyclopropylisoxazol-3-yl)-1-isopropyl-1H-pyrazole-4-carboxamide as a specific RET
kinase
inhibitor
作者:
Hojong Yoon
a
;
1
;
Injae Shin
b
;
1
;
Yunju Nam
b
;
Nam Doo Kim
c
;
Kyung-Bok Lee
d
;
Taebo Sim
a
;
b
;
tbsim@kist.re.kr
关键词:
RET
kinase
;
Metabolic stability
;
Specific
inhibitor
;
5-Aminopyrazole-4-carboxamide
刊名:European Journal of Medicinal Chemistry
出版年:2017
5.
Binding studies and biological evaluation of β-carotene as a potential
inhibitor
of human calcium/calmodulin-dependent protein
kinase
IV
作者:
Huma Naz
a
;
Parvez Khan
a
;
Mohd. Tarique
b
;
Safikur Rahman
c
;
Abha Meena
d
;
Shahzaib Ahamad
e
;
Suaib Luqman
d
;
Asimul Islam
a
;
Faizan Ahmad
a
;
Md. Imtaiyaz Hassan
a
;
mihassan@jmi.ac.in
关键词:
Calcium/calmodulin-dependent protein
kinase
IV
;
β-carotene
;
Anticancer activity
;
Kinase
inhibitor
;
Apoptosis
刊名:International Journal of Biological Macromolecules
出版年:2017
6.
IκB
kinase
inhibition as a potential treatment of osteoarthritis - results of a clinical proof-of-concept study
作者:
K. Grothe
&dagger
;
;
Kirsten.Grothe@sanofi.com
;
K. Flechsenhar
&dagger
;
;
Klaus.Flechsenhar@sanofi.com
;
T. Paehler
&Dagger
;
;
Tobias.Paehler@sanofi.com
;
O. Ritzeler
§
;
;
Olaf.Ritzeler@sanofi.com
;
J. Beninga
‖
;
Jochen.Beninga@sanofi.com
;
J. Saas
&dagger
;
;
Joachim.Saas@sanofi.com
;
M. Herrmann
&dagger
;
;
Matthias.Herrmann@sanofi.com
;
K. Rudolphi
&dagger
;
;
Karl.Rudolphi@sanofi.com
关键词:
IκB
kinase
inhibitor
;
Slow-release formulation
;
Intra-articular injection
;
Treatment of knee osteoarthritis
;
Clinical findings
刊名:Osteoarthritis and Cartilage
出版年:2017
7.
Class I phosphatidylinositol 3-
kinase
inhibitor
s for cancer therapy
作者:
Wennan Zhao
&dagger
;
;
Yuling Qiu
&dagger
;
;
Dexin Kong
;
kongdexin@tmu.edu.cn
关键词:
Phosphatidylinositol 3-
kinase
;
PI3K
inhibitor
;
Drug candidate
;
Cancer therapy
;
PI3K/mTOR selectivity
;
Anticancer
刊名:Acta Pharmaceutica Sinica B
出版年:2017
8.
Discovering novel 7-azaindole-based series as potent AXL
kinase
inhibitor
s
作者:
Clé
;
mence Feneyrolles
;
Lé
;
a Guiet
;
Mathilde Singer
;
Nathalie Van Hijfte
;
Bé
;
né
;
dicte Daydé
;
-Cazals
;
Bé
;
né
;
dicte Fauvel
;
Gwé
;
naë
;
l Chevé
;
Abdelaziz Yasri
;
ayasri@oribase-pharma.com
关键词:
AXL
;
7-Azaindole
;
Receptor tyrosine
kinase
;
Kinase
inhibitor
;
Modeling study
;
Medicinal chemistry
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2017
9.
Identification of a selective
inhibitor
of transforming growth factor β-activated
kinase
1 by biosensor-based screening of focused libraries
作者:
Takaaki Miura
a
;
miuratka@chugai-pharm.co.jp
;
Atsushi Matsuo
b
;
Terushige Muraoka
b
;
Mitsuaki Ide
b
;
Kenji Morikami
b
;
Takayuki Kamikawa
a
;
Masamichi Nishihara
b
;
Hirotaka Kashiwagi
b
关键词:
TAK1
;
Chemogenomic approach
;
Selective Type I
inhibitor
;
Biophysical screening
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2017
10.
Compound Selectivity and Target Residence Time of
Kinase
Inhibitor
s Studied with Surface Plasmon Resonance
作者:
Nicole Willemsen-Seegers
1
;
Joost C.M. Uitdehaag
1
;
Martine B.W. Prinsen
1
;
Judith R.F. de Vetter
1
;
Jos de Man
1
;
Masaaki Sawa
2
;
Yusuke Kawase
2
;
Rogier C. Buijsman
1
;
Guido J.R. Zaman
1
;
guido.zaman@ntrc.nl
关键词:
FDA
;
US Food and Drug Administration
;
EGFR
;
epidermal growth factor receptor
;
BTK
;
Bruton's tyrosine
kinase
;
SPR
;
surface plasmon resonance
;
PI3K
;
phosphoinositide 3-
kinase
;
SD
;
standard deviation
;
SE
;
standard error
;
PI3K
;
phosphoinositide 3-
kinase
;
SPR
;
surface plasmon resonance
刊名:Journal of Molecular Biology
出版年:2017
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