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内部出版物
SpringerLink电子期刊(5)
Elsevier电子期刊(35)
在“
Elsevier电子期刊
”中,
命中:
35
条,耗时:小于0.01 秒
在所有数据库中总计命中:
40
条
1.
Toxicological evaluation of two novel bitter modifying flavour com
p
ounds: 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-
p
yrazol-4-yl)-1-(3-hydroxybenzyl)imidazolidine-2,4-
dione
and 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-
p
yrazol-4-yl)-1-(3-hydroxybenzyl)-5,5-dimethylimidazolidine-2,4-
dione
作者:
Donald
S. Karanewsky
;
Amy J. Arthur
p>
;
p>
p>amy.arthur@senomyx.com
p>
;
Hanghui Liu
;
Bert Chi
;
Lily Ida
;
Stacy Markison
关键词:
AUC
;
area under the curve
;
CL
;
p
lasma clearance
;
Cmax
;
p
eak
p
lasma concentration
;
CY
P
;
cytochrome
P
450
;
FDA
;
Food and Drug Administration
;
FEMA
;
Flavour and Extract Manufacturers Association of the United States
;
GL
P
;
Good Laboratory
P
ractices
;
GM
P
;
good manufacturing
p
ractices
;
G
P
CR
;
G
p
rotein-cou
p
led rece
p
tors
;
H
P
BL
;
human
p
eri
p
heral blood lym
p
hocytes
;
JECFA
;
Joint FAO/WHO Ex
p
ert Committee on Food Additives
;
LC/MS
;
liquid chromatogra
p
hy with mass s
p
ectrometry
;
MC
;
methylcellulose
;
mn
P
CE
;
micro
刊名:Toxicology Re
p
orts
出版年:2016
2.
Synthesis of a dansyl-labeled inhibitor of 17β-hydroxysteroid dehydrogenase ty
p
e 3 for o
p
tical imaging
作者:
Lucie Carolle Kenmogne
p>a
p>
;
René
;
Maltais
p>a
p>
;
Donald
P
oirier
p>a
p>
p>
;
p>
p>b
p>
p>
;
p>
p>
donald
.
p
oirier@crchul.ulaval.ca" class="auth_mail" title="E-mail the corres
p
onding author
p>
关键词:
Steroid
;
Fluorescent agent
;
Dansyl
;
Hydroxysteroid dehydrogenase
;
Inhibitor
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
3.
Re
p
rint of 鈥?s
p
an style='font-style: italic'>In vitro and in vivo evaluation of a 3尾-androsterone derivative as inhibitor of 17尾-hydroxysteroid dehydrogenase ty
p
e 3鈥?
作者:
Jenny Roy
;
Michelle-Audrey Fournier
;
René
;
Maltais
;
Lucie Carolle Kenmogne
;
Donald
P
oirier
p>
;
p>
p>
donald
.
p
oirier@crchul.ulaval.ca" class="auth_mail" title="E-mail the corres
p
onding author
p>
关键词:
AR
;
androgen rece
p
tor
;
A-diol
;
5伪-androstane-3伪
;
17尾-diol
;
A-
dione
;
5伪-androstane-3
;
17-
dione
;
5-diol
;
5-androstene-3尾
;
17尾-diol
;
4-
dione
;
4-androstene-3
;
17-
dione
;
ADT
;
androsterone
;
AUC
;
area under curve
;
CTX
;
castrated
;
CTL
;
control
;
DHEA
;
dehydroe
p
iandrosterone
;
DHT
;
dihydrotestosterone
;
DMSO
;
dimethyl sulfoxide
;
E2
;
estradiol
;
E1
;
estrone
;
EDTA
;
ethylenediaminetetraacetic acid
;
GC
;
gas chromatogra
p
hy
;
IC50
;
half maximal inhibitory concentration
;
P
450c17
;
17尾-hydroxylase/17
;
20-lyase
;
17尾-HSD3 or
刊名:Journal of Steroid Biochemistry and Molecular Biology
出版年:2015
4.
In vitro and in vivo evaluation of a 3尾-androsterone derivative as inhibitor of 17尾-hydroxysteroid dehydrogenase ty
p
e 3
作者:
Jenny Roy
;
Michelle-Audrey Fournier
;
René
;
Maltais
;
Lucie Carolle Kenmogne
;
Donald
P
oirier
p>
;
p>
p>
donald
.
p
oirier@crchul.ulaval.ca" class="auth_mail
p>
关键词:
AR
;
androgen rece
p
tor
;
A-diol
;
5伪-androstane-3伪
;
17尾-diol
;
A-
dione
;
5伪-androstane-3
;
17-
dione
;
5-diol
;
5-androstene-3尾
;
17尾-diol
;
4-
dione
;
4-androstene-3
;
17-
dione
;
ADT
;
androsterone
;
AUC
;
area under curve
;
CTX
;
castrated
;
CTL
;
control
;
DHEA
;
dehydroe
p
iandrosterone
;
DHT
;
dihydrotestosterone
;
DMSO
;
dimethyl sulfoxide
;
E2
;
estradiol
;
E1
;
estrone
;
EDTA
;
ethylenediaminetetraacetic acid
;
GC
;
gas chromatogra
p
hy
;
IC50
;
half maximal inhibitory concentration
;
P
450c17
;
17尾-hydroxylase/17
;
20-lyase
;
17尾
刊名:The Journal of Steroid Biochemistry and Molecular Biology
出版年:May, 2014
5.
Contour tracking in echocardiogra
p
hic sequences via s
p
arse re
p
resentation and dictionary learning
作者:
Xiaojie Huang
;
Donald
P
.
Dione
;
Colin B. Com
p
as
;
Xeno
p
hon Pa
p
ademetris
;
Ben A. Lin
;
Alda Bregasi
;
Albert J. Sinusas
;
Lawrence H. Staib
;
James S. Duncan
关键词:
Echocardiogra
p
hy
;
Segmentation
;
Contour tracking
;
S
p
arse re
p
resentation
;
Dictionary learning
刊名:Medical Image Analysis
出版年:February, 2014
6.
Develo
p
ment of a sensitive LC/MS/MS method for vitamin D metabolites: 1,25 Dihydroxyvitamin D
2&3
measurement using a novel derivatization agent
作者:
Curtis J. Hedman
p>a
p>
p>
;
p>
p>b
p>
p>
;
p>
p>c
p>
;
Donald
A. Wiebe
p>d
p>
;
Subhakar Dey
p>f
p>
;
Josh
P
lath
p>f
p>
;
Jose
p
h W. Kemnitz
p>a
p>
p>
;
p>
p>b
p>
p>
;
p>
p>e
p>
;
Toni E. Ziegler
p>a
p>
p>
;
p>
p>b
p>
p>
;
p>
p>ziegler@
p
rimate.wisc.edu" class="auth_mail
p>
关键词:
Liquid chromatogra
p
hy
;
Tandem mass s
p
ectrometry
;
1
;
25 Dihydroxyvitamin D
;
Derivatization method
刊名:Journal of Chromatogra
p
hy B, Analytical Technologies in the Biomedical and Life Sciences
出版年:15 March, 2014
7.
Cyclohexane 1,3-
dione
s and their inhibition of mutant SOD1-de
p
endent
p
rotein aggregation and toxicity in PC12 cells
作者:
Wei Zhang
p>a
p>
p>
;
p>
p>&dagger
;
p>
;
Radhia Benmohamed
p>b
p>
;
Anthony C. Arvanites
p>b
p>
p>
;
p>
p>&Dagger
;
p>
;
Richard I. Morimoto
p>c
p>
;
Robert J. Ferrante
p>d
p>
p>
;
p>
p>e
p>
;
Donald
R. Kirsch
p>b
p>
;
Richard B. Silverman
p>a
p>
p>
;
p>
p>f
p>
p>
;
p>
p>Agman@chem.northwestern.edu
p>
关键词:
Cyclohexane-1
;
3-
dione
;
Amyotro
p
hic lateral sclerosis
;
Mutant G93A SOD1
;
Blood&ndash
;
brain barrier
p
enetration
刊名:Bioorganic and Medicinal Chemistry
出版年:2012
8.
Synthesis and biological activity evaluation of 5-
p
yrazoline substituted 4-thiazolidinones
作者:
Dmytro Havrylyuk
;
Borys Zimenkovsky
;
Olex
;
r Vasylenko
;
Craig W. Day
;
Donald
F. Smee
;
P
hili
pp
e Grellier
;
Roman Lesyk
关键词:
Synthesis
;
P
yrazolines
;
4-Thiazolidinones
;
Anticancer activity
;
Antitry
p
anosomal activity
;
Antiviral activity
刊名:Euro
p
ean Journal of Medicinal Chemistry
出版年:2013
9.
Structure-based design of isoindoline-1,3-
dione
s and 2,3-dihydro
p
hthalazine-1,4-
dione
s as novel B-Raf inhibitors
作者:
Xiaolun
;
Wang
p>a
p>
p>
;
;
p>
p>b
p>
p>
;
;
p>
p>xxw104@gmail.com
p>
;
Edward J.
;
Salaski
p>a
p>
;
Dan M.
;
Berger
p>a
p>
p>
;
;
p>
p>&dagger
;
p>
;
Dennis
;
P
owell
p>a
p>
;
Yongbo
;
Hu
p>a
p>
p>
;
;
p>
p>&Dagger
;
p>
;
Donald
;
Wojciechowicz
p>a
p>
;
Karen
;
Collins
p>a
p>
;
Eileen
;
Frommer
p>a
p>
关键词:
B-Raf inhibitors
;
Structure-based drug design
;
Ty
p
e I kinase inhibitors
;
Ty
p
e II kinase inhibitors
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2011
10.
Develo
p
ment of 3-substituted-androsterone derivatives as
p
otent inhibitors of 17β-hydroxysteroid dehydrogenase ty
p
e 3
作者:
René
;
Maltais
p>a
p>
;
Michelle-Audrey Fournier
p>a
p>
;
Donald
P
oirier
p>a
p>
p>
;
p>
p>b
p>
p>
;
p>
p>
donald
.
p
oirier@crchul.ulaval.ca"" rel=""nofollow
p>
关键词:
Steroid
;
Androsterone
;
Enzyme
;
Hydroxysteroid dehydrogenase
;
Cancer
;
Androgen
;
Hormone
刊名:Bioorganic and Medicinal Chemistry
出版年:2011
1
2
3
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