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1.Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (nN → σ*S–X) Interaction fo
9.Design and Synthesis of Potent, Orally Efficacious Hydroxyethylamine Derived 尾-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors
10.Design and Preparation of a Potent Series of Hydroxyethylamine Containing 尾-Secretase Inhibitors That Demonstrate Robust Reduction of Central 尾-Amyloid
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