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ACS电子期刊(33)

在“ACS电子期刊”中，命中：33条，耗时：小于0.01 秒

在所有数据库中总计命中：66条

1.Fragment-Linking Approach Using 19F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase

作者：John B. Jordan ; Douglas A. Whittington ; Michael D. Bartberger ; E. Allen Sickmier ; Kui Chen ; Yuan Cheng ; Ted Judd

刊名：Journal of Medicinal Chemistry

出版年：2016

2.Discovery and in Vivo Evaluation of the Potent and Selective PI3Kδ Inhibitors 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-0687) and 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-5-fluoro-N-methyl-3-(2-pyridinyl)-4-quino

作者：Felix Gonzalez-Lopez de Turiso ; Xiaolin Hao ; Youngsook Shin ; Minna Bui ; Iain D. G. Campuzano ; Mario Cardozo ; Michelle C. Dunn ; Jason Duquette ; Benjamin Fisher ; Robert S. Foti ; Kirk Henne ; Xiao He ; Yi-Ling Hu ; Ron C. Kelly ; Michael G. Johnson ; Brian S. Lucas ; John McCarter ; Lawrence R. McGee ; Julio C. Medina ; Daniela Metz ; Tisha San Miguel ; Deanna Mohn ; Thuy Tran ; Christine Vissinga ; Sharon Wannberg ; Douglas A. Whittington ; John Whoriskey ; Gang Yu ; Leeanne Zalameda ; Xuxia Zhang ; Timothy D. Cushing

刊名：Journal of Medicinal Chemistry

出版年：2016

3.Discovery of (R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo A

作者：Alessandro A. Boezio ; Katrina W. Copeland ; Karen Rex ; Brian K. Albrecht ; David Bauer ; Steven F. Bellon ; Christiane Boezio ; Martin A. Broome ; Deborah Choquette ; Angela Coxon ; Isabelle Dussault ; Satoko Hirai ; Richard Lewis ; Min-Hwa Jasmine Lin ; Julia Lohman ; Jingzhou Liu ; Emily A. Peterson ; Michele Potashman ; Roman Shimanovich ; Yohannes Teffera ; Douglas A. Whittington ; Karina R. Vaida ; Jean-Christophe Harmange

刊名：Journal of Medicinal Chemistry

出版年：2016

4.Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3Kδ Inhibitors

作者：Youngsook Shin ; Julia Suchomel ; Mario Cardozo ; Jason Duquette ; Xiao He ; Kirk Henne ; Yi-Ling Hu ; Ron C. Kelly ; John McCarter ; Lawrence R. McGee ; Julio C. Medina ; Daniela Metz ; Tisha San Miguel ; Deanna Mohn ; Thuy Tran ; Christine Vissinga ; Simon Wong ; Sharon Wannberg ; Douglas A. Whittington ; John Whoriskey ; Gang Yu ; Leeanne Zalameda ; Xuxia Zhang ; Timothy D. Cushing

刊名：Journal of Medicinal Chemistry

出版年：2016

5.An Orally Available BACE1 Inhibitor That Affords Robust CNS A尾 Reduction without Cardiovascular Liabilities

作者：Yuan Cheng ; James Brown ; Ted C. Judd ; Patricia Lopez ; Wenyuan Qian ; Timothy S. Powers ; Jian Jeffrey Chen ; Michael D. Bartberger ; Kui Chen ; Robert T. Dunn ; II ; Oleg Epstein ; Robert T. Fremeau ; Jr. ; Scott Harried ; Dean Hickman ; Stephen A. Hitchcock ; Yi Luo ; Ana Elena Minatti ; Vinod F. Patel ; Hugo M. Vargas ; Robert C. Wahl ; Matthew M. Weiss ; Paul H. Wen ; Ryan D. White ; Douglas A. Whittington ; Xiao Mei Zheng ; Stephen Wood

刊名：ACS Medicinal Chemistry Letters

出版年：2015

6.Correction to Discovery of Potent and Selective 8-Fluorotriazolopyridine c-Met Inhibitors

作者：Emily A. Peterson ; Yohannes Teffera ; Brian K. Albrecht ; David Bauer ; Steven F. Bellon ; Alessandro Boezio ; Christiane Boezio ; Martin A. Broome ; Deborah Choquette ; Katrina W. Copeland ; Isabelle Dussault ; Richard Lewis ; Min-Hwa Jasmine Lin ; Julia Lohman ; Jingzhou Liu ; Michele Potashman ; Karen Rex ; Roman Shimanovich ; Douglas A. Whittington ; Karina R. Vaida ; Jean-Christophe Harmange

刊名：Journal of Medicinal Chemistry

出版年：2015

7.Discovery and in Vivo Evaluation of (S)-N-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and Related PI3K未 Inhibitors for Inflammation and Autoimmune

作者：Timothy D. Cushing ; Xiaolin Hao ; Youngsook Shin ; Kristin Andrews ; Matthew Brown ; Mario Cardozo ; Yi Chen ; Jason Duquette ; Ben Fisher ; Felix Gonzalez-Lopez de Turiso ; Xiao He ; Kirk R. Henne ; Yi-Ling Hu ; Randall Hungate ; Michael G. Johnson ; Ron C. Kelly ; Brian Lucas ; John D. McCarter ; Lawrence R. McGee ; Julio C. Medina ; Tisha San Miguel ; Deanna Mohn ; Vatee Pattaropong ; Liping H. Pettus ; Andreas Reichelt ; Robert M. Rzasa ; Jennifer Seganish ; Andrew S. Tasker ; Robert C. Wahl ; Sharon Wannberg ; Douglas A. Whittington ; John Whoriskey ; Gang Yu ; Leeanne Zalameda ; Dawei Zhang ; Daniela P. Metz

刊名：Journal of Medicinal Chemistry

出版年：2015

8.Inhibitors of 尾-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1): Identification of (S)-7-(2-Fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5鈥?i>H-spiro[chromeno[2,3-b]py

作者：Thomas A. Dineen ; Kui Chen ; Alan C. Cheng ; Katayoun Derakhchan ; Oleg Epstein ; Joel Esmay ; Dean Hickman ; Chuck E. Kreiman ; Isaac E. Marx ; Robert C. Wahl ; Paul H. Wen ; Matthew M. Weiss ; Douglas A. Whittington ; Stephen Wood ; Robert T. Fremeau ; Jr. ; Ryan D. White ; Vinod F. Patel

刊名：Journal of Medicinal Chemistry

出版年：2014

9.Lead Optimization and Modulation of hERG Activity in a Series of Aminooxazoline Xanthene 尾-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors

作者：Oleg Epstein ; Marian C. Bryan ; Alan C. Cheng ; Katayoun Derakhchan ; Thomas A. Dineen ; Dean Hickman ; Zihao Hua ; Jason B. Human ; Charles Kreiman ; Isaac E. Marx ; Matthew M. Weiss ; Robert C. Wahl ; Paul H. Wen ; Douglas A. Whittington ; Stephen Wood ; Xiao Mei Zheng ; Robert T. Fremeau ; Jr. ; Ryan D. White ; Vinod F. Patel

刊名：Journal of Medicinal Chemistry

出版年：2014

10.The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment of Cancer

作者：Richard T. Lewis ; Christiane M. Bode ; Deborah M. Choquette ; Michele Potashman ; Karina Romero ; John C. Stellwagen ; Yohannes Teffera ; Earl Moore ; Douglas A. Whittington ; Hao Chen ; Linda F. Epstein ; Renee Emkey ; Paul S. Andrews ; Violeta L. Yu ; Douglas C. Saffran ; Man Xu ; Allison Drew ; Patricia Merkel ; Steven Szilvassy ; Rachael L. Brake

刊名：Journal of Medicinal Chemistry

出版年：2012

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