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Elsevier电子期刊(12)

在“Elsevier电子期刊”中，命中：12条，耗时：0.012982 秒

在所有数据库中总计命中：12条

1.Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy

作者：Youssef Dgachi^a ; Olga Sokolov^b ; Vincent Luzet^b ; Justyna Godyń^c ; Dawid Panek^c ; Alexandre Bonet^d ; Hé ; lè ; ne Martin^d ; Isabel Iriepa^e ; Ignacio Moraleda^e ; Cristina Garcí ; a-Iriepa^f ; Jana Janockova^g ; Lysiane Richert^d ; Ondrej Soukup^g ; Barbara Malawska^c ; Fakher Chabchoub^a ; ^{fakher.chabchoub@yahoo.fr} ; José ; Marco-Contelles^h ; ^{iqoc21@iqog.csic.es} ; Lhassane Ismaili^b ; ^{lhassane.ismaili@univ-fcomte.fr}

关键词：Alzheimer's disease ; Acetylcholinesterase inhibitors ; Antioxidants ; Hepatotoxicity ; Brain blood barrier ; Molecular modeling ; Multifunctional agents

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.Potent anticholinesterasic and neuroprotective pyranotacrines as inhibitors of beta-amyloid aggregation, oxidative stress and tau-phosphorylation for Alzheimer's disease

作者：Nuria Garcí ; a-Font^a ; ^b ; Hasna Hayour^c ; Ali Belfaitah^c ; ^{abelbelfaitah@yahoo.fr" class="auth_mail" title="E-mail the corresponding author} ; Jorge Pedraz^a ; Ignacio Moraleda^d ; Isabel Iriepa^d ; Abdelmalek Bouraiou^c ; Mourad Chioua^e ; José ; Marco-Contelles^b ; ^e ; ^{iqoc21@iqog.csci.es" class="auth_mail" title="E-mail the corresponding author} ; Marí ; a Jesú ; s Oset-Gasque^a ; ^b ; ^{mjoset@ucm.es" class="auth_mail" title="E-mail the corresponding author}

关键词：Tacrine ; Alzheimer's disease ; Anticholinesterasics ; Neuroprotection ; Beta-amyloid aggregation ; Tau-phosphorylation

刊名：European Journal of Medicinal Chemistry

出版年：2016

3.Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease

作者：Oscar M. Bautista-Aguilera^a ; ¹ ; Gerard Esteban^b ; ¹ ; Irene Bolea^b ; Katarina Nikolic^c ; Danica Agbaba^c ; Ignacio Moraleda^d ; Isabel Iriepa^d ; Abdelouahid Samadi^a ; Elena Soriano^e ; Mercedes Unzeta^b ; José ; Marco-Contelles^a ; ^{iqoc21@iqog.csic.es" class="auth_mail}

关键词：Donepezil ; Donepezil&ndash ; indolyl hybrids ; EeAChE ; eqBuChE ; hMAO A ; hMAO B ; Inhibitors ; 3D-QSAR ; Molecular modeling ; ADMET

刊名：European Journal of Medicinal Chemistry

出版年：21 March, 2014

4.Toxicological and pharmacological evaluation, antioxidant, ADMET and molecular modeling of selected racemic chromenotacrines {11-amino-12-aryl-8,9,10,12-tetrahydro-7H-chromeno[2,3-b]quinolin-3-ols} for the potential prevention and treatment of Alzheimer's disease

作者：Marí ; a Jesú ; s Oset-Gasque^a ; ^b ; ^{mjoset@ucm.es" class="auth_mail} ; Marí ; a Pilar Gonzá ; lez^a ; Javier Pé ; rez-Peñ ; a^a ; Nuria Garcí ; a-Font^a ; Alejandro Romero^c ; Javier del Pino^c ; Eva Ramos^c ; Dimitra Hadjipavlou-Litina^d ; Elena Soriano^e ; Mourad Chioua^f ; Abdelouahid Samadi^f ; Dushyant S. Raghuvanshi^g ; Krishna N. Singh^g ; ^{knsinghbhu@yahoo.co.in" class="auth_mail} ; José ; Marco-Contelles^f ; ^b ; ^{iqoc21@iqog.csic.es" class="auth_mail}

关键词：11-Amino-12-aryl-89 ; 10 ; 12-tetrahydro-7H-chromeno[2 ; 3-b]quinolin-3-ols ; Tacrine analogs ; Toxicity ; EeAChE ; hBuChE ; Kinetic analysis ; Inhibition mechanism ; Antioxidant ; Neuroprotection ; Molecular modeling ; ADMET ; Alzheimer's disease

刊名：European Journal of Medicinal Chemistry

出版年：3 March, 2014

5.Analysis of the antioxidant properties of differently substituted 2- and 3-indolyl carbohydrazides and related derivatives

作者：Dimitra Hadjipavlou-Litina^a ; ^{hadjipav@pharm.auth.gr} ; Abdelouahid Samadi^b ; Mercedes Unzeta^c ; José ; Marco-Contelles^b ; ^{iqoc21@iqog.csic.es}

关键词：Substituted 2- and 3-indolyl carbohydrazides ; Antioxidant ; ROS ; DPPH ; Lipid peroxidation ; APPH ; Hydroxyl radicals ; Superoxide anion radical (O2) ; LOX

刊名：European Journal of Medicinal Chemistry

出版年：2013

6.Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer¡¯s disease

作者：Alejandro Romero^a ; ; Ramó ; n Cacabelos^b ; Marí ; a J. Oset-Gasque^c ; Abdelouahid Samadi^d ; José ; Marco-Contelles^d ; ^{iqoc21@iqog.csic.es}

关键词：Tacrine ; Cholinesterase inhibitors ; Multi-target-directed ligands ; New tacrine hybrids ; Hepatotoxicity ; Alzheimer&rsquo ; s disease

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2013

7.Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: Synthesis, biological assessment, and molecular modeling

作者：Abdelouahid Samadi^a ; ^{samadi@iqog.csic.es} ; Martí ; n Estrada^b ; Concepció ; n Pé ; rez^b ; Marí ; a Isabel Rodrí ; guez-Franco^b ; Isabel Iriepa^c ; Ignacio Moraleda^c ; Mourad Chioua^a ; José ; Marco-Contelles^a ; ^{iqoc21@iqog.csic.es}

关键词：Pyridonepezils ; hAChE ; hBuChE ; Dual AChE inhibitors ; In vitro blood brain barrier ; Molecular modeling ; ADME ; Alzheimer's disease

刊名：European Journal of Medicinal Chemistry

出版年：2012

8.Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease

作者：Emna Maalej^a ; Fakher Chabchoub^a ; ^{fakher.chabchoub@yahoo.fr} ; Marí ; a Jesú ; s Oset-Gasque^b ; ^c ; Mario Esquivias-Pé ; rez^b ; Marí ; a P. Gonzá ; lez^b ; Leticia Monjas^d ; Concepció ; n Pé ; rez^d ; Cristó ; bal de los Rí ; os^e ; Marí ; a Isabel Rodrí ; guez-Franco^d ; Isabel Iriepa^f ; Ignacio Moraleda^f ; Mourad Chioua^g ; Alejandro Romero^h ; José ; Marco-Contelles^g ; ^{iqoc21@iqog.csic.es} ; Abdelouahid Samadi^g

关键词：7-Aryl-9 ; 10 ; 11 ; 12-tetrahydro-7H-benzo[7 ; 8]chromeno[2 ; 3-b]quinolin-8-amines ; hAChE ; hBuChE ; Kinetic analysis ; Inhibition mechanism ; Antioxidant ; ORAC ; Neuroprotection ; Toxicity ; Molecular modeling ; Alzheimer's disease

刊名：European Journal of Medicinal Chemistry

出版年：2012

9.Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues

作者：Carla Martins^a ; M. Carmo Carreiras^a ; ^{mcdamaso@ff.ul.pt} ; ^{micarreiras@gmail.com} ; Rafael Leó ; n^b ; ^c ; Cristó ; bal de los Rí ; os^d ; ^e ; Manuela Bartolini^f ; Vincenza Andrisano^f ; Isabel Iriepa^d ; Ignacio Moraleda^d ; Enrique Gá ; lvez^d ; Manuela Garcí ; a^c ; ^g ; Javier Egea^c ; Abdelouhaid Samadi^b ; Mourad Chioua^b ; José ; Marco-Contelles^b ; ^{iqoc21@iqog.csic.es}

关键词：AChE/BuChE inhibitors ; Neuroprotection ; Alzheimer&rsquo ; s disease

刊名：European Journal of Medicinal Chemistry

出版年：2011

10.Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9H-benzo[5,6]chromeno[2,3-b]quinolin-13-amines

作者：Emna Maalej^a ; ; Fakher Chabchoub^a ; ^{fakher.chabchoub@yahoo.fr} ; Abdelouahid Samadi^b ; Cristó ; bal de los Rí ; os^c ; Almudena Perona^d ; Antonio Morreale^d ; José ; Marco-Contelles^b ; ^{iqoc21@iqog.csic.es}

关键词：AChE ; BuChE ; Kinetic analysis ; Inhibition mechanism ; Docking analysis ; Molecular dynamics simulation ; Alzheimer’ ; s disease

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2011

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