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SpringerLink电子期刊(254)

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在“Elsevier电子期刊”中，命中：83条，耗时：小于0.01 秒

在所有数据库中总计命中：348条

1.Gamma secretase inhibitor impairs epithelial-to-mesenchymal transition induced by TGF-β in ovarian tumor cell lines

作者：M.C. Pazos ^{mariacamilapazos@gmail.com} ; D. Abramovich ^{dnabramovich@gmail.com} ; A. Bechis ^{andy_bechis@hotmail.com} ; P. Accialini ^{paccialini@gmail.com} ; F. Parborell ^{fparborell@gmail.com} ; M. Tesone ^{martatesone.uba@gmail.com} ; G. Irusta ; ^{irustag@gmail.com}

关键词：Gamma secretase inhibitor ; Epithelial-to-mesenchymal transition ; TGF-β ; Cadherin switch ; Metastasis ; Ovarian cancer

刊名：Molecular and Cellular Endocrinology

出版年：2017

2.Neuritogenic activity of bi-functional bis-tryptoline triazole

作者：Jutamas Jiaranaikulwanitch^a ; ^b ; ^{jutamas.jia@cmu.ac.th} ; Sarin Tadtong^c ; Piyarat Govitrapong^d ; Valery V. Fokin^e ; Opa Vajragupta^b

关键词：Bis-tryptoline triazole ; Multifunctional activity ; Neuritogenic activity ; β-secretase inhibitor ; β-amyloid aggregation

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

3.Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment

作者：Zuzana Gazova^a ; ^{gazova@saske.sk} ; Ondrej Soukup^b ; ^c ; ^d ; Vendula Sepsova^b ; ^c ; Katarina Siposova^a ; Lucie Drtinova^c ; Petr Jost^b ; ^c ; Katarina Spilovska^b ; ^c ; ^d ; Jan Korabecny^b ; ^c ; ^d ; Eugenie Nepovimova^b ; ^c ; Diana Fedunova^a ; Martin Horak^e ; Martina Kaniakova^e ; Ze-Jun Wang^f ; Ayman K. Hamouda^f ; Kamil Kuca^b ; ^c ; ^d

关键词：Amyloid ; Aggregation ; Aβ peptide ; Muscarinic/nicotinic acetylcholine receptor antagonist ; N-Methyl-d-aspartate receptor antagonist ; β-Secretase inhibitor ; Alzheimer's disease

刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

出版年：2017

4.Anomalies occurring in lipid profiles and protein distribution in frontal cortex lipid rafts in dementia with Lewy bodies disclose neurochemical traits partially shared by Alzheimer's and Parkinson's diseases

作者：Raquel Marin^a ; Noemí ; Fabelo^b ; Virginia Martí ; n^c ; Paula Garcia-Esparcia^d ; Isidre Ferrer^d ; David Quinto-Alemany^b ; Mario Dí ; az^b ; ^{madiaz@ull.es}

关键词：Lipid rafts ; Docosahexaenoic acid ; Cholesterol ; Plasmalogens ; β-secretase ; Amyloid precursor protein ; Amyloidogenic processing ; Human brain cortex ; Lewy body diseases ; Alzheimer's disease ; Parkinson's disease

刊名：Neurobiology of Aging

出版年：2017

5.Ginsenoside Rd promotes non-amyloidogenic pathway of amyloid precursor protein processing by regulating phosphorylation of estrogen receptor alpha

作者：Xiaodong Yan^a ; ¹ ; Gengyao Hu^b ; ¹ ; Weiming Yan^c ; ¹ ; Tao Chen^c ; ^e ; Feng Yang^a ; ^d ; Xiao Zhang^b ; Gang Zhao^b ; ^{zhaogang@fmmu.edu.cn} ; Juanfang Liu^c ; ^{juanfangliu@163.com}

关键词：GS-Rd ; Alzheimer's disease ; Amyloid-β precursor protein (APP) processing ; Aβ ; MAPK and PI3K pathway ; ER

刊名：Life Sciences

出版年：2017

6.Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation

作者：Dawid Panek^a ; ¹ ; Anna Więckowska^a ; ¹ ; Tomasz Wichur^a ; Marek Bajda^a ; Justyna Godyń^a ; Jakub Jończyk^a ; Kamil Mika^a ; Jana Janockova^b ; Ondrej Soukup^b ; Damijan Knez^c ; Jan Korabecny^b ; Stanislav Gobec^c ; Barbara Malawska^a ; ^{mfmalaws@cyf-kr.edu.pl}

关键词：Alzheimer's disease ; Multifunctional agents ; Acetylcholinesterase inhibitors ; BACE1 inhibitors ; Aβ aggregation ; Molecular docking

刊名：European Journal of Medicinal Chemistry

出版年：2017

7.Phenylpropanoids from cinnamon bark reduced β-amyloid production by the inhibition of β-secretase in Chinese hamster ovarian cells stably expressing amyloid precursor protein

作者：Yu Jeong Kang^a ; ¹ ; Dae-Gun Seo^b ; ¹ ; So-Young Park^a ; ^b ; ^{soypark23@dankook.ac.kr}

关键词：Cinnamomum cassia ; β-Amyloid ; Alzheimer disease ; β-Secretase ; Medioresinol ; Cryptamygin A

刊名：Nutrition Research

出版年：2016

8.Design, synthesis and SAR analysis of potent BACE1 inhibitors: Possible lead drug candidates for Alzheimer's disease

作者：Hamadeh Tarazi^a ; ^b ; Raed Abu Odeh^b ; ^c ; Raed Al-Qawasmeh^d ; Imad Abu Yousef^e ; Wolfgang Voelter^f ; Taleb H. Al-Tel^a ; ^b ; ^{taltal@sharjah.ac.ae}

关键词：β-secretase inhibitors ; Alzheimer's disease ; Transition state mimics ; Structure-based drug design ; Structure activity relationship ; Isophthalic acid derivatives ; Molecular modeling

刊名：European Journal of Medicinal Chemistry

出版年：2017

9.BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease

作者：Robert H. Scannevin^a ; ^{robert.scannevin@biogen.com" class="auth_mail" title="E-mail the corresponding author} ; Sowmya Chollate^a ; ¹ ; Melanie S. Brennan^a ; Pamela A. Snodgrass-Belt^a ; ² ; Hairuo Peng^b ; Lin Xu^c ; Mi-young Jung^a ; Thierry Bussiere^a ; Mahin F. Arastu^a ; ³ ; Tina Talreja^b ; ⁴ ; Zhili Xin^b ; Robert W. Dunstan^d ; Diana Fahrer^d ; Ellen Rohde^c ; ⁵ ; Anthone W. Dunah^a ; Joy Wang^a ; ⁶ ; Gnanasambandam Kumaravel^b ; Arthur G. Taveras^b ; ⁷ ; H. Moore Arnold^a ; Kenneth J. Rhodes^a ; ⁸

关键词：Amyloid β ; γ-Secretase ; γ-Secretase modulator ; Alzheimer's disease ; Amyloid precursor protein

刊名：Neuropharmacology

出版年：2016

10.Maturation and processing of the amyloid precursor protein is regulated by the potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2)

作者：Susanne Frykman^a ; ^{susanne.frykman@ki.se} ; Mitsuhiro Inoue^a ; ^b ; Atsushi Ikeda^b ; Yasuhiro Teranishi^a ; ^b ; Takahiro Kihara^a ; ^b ; Jolanta L. Lundgren^a ; Natsuko G. Yamamoto^a ; ^b ; Nenad Bogdanovic^a ; Bengt Winblad^a ; Sophia Schedin-Weiss^a ; Lars O. Tjernberg^a

关键词：Amyloid precursor protein ; Amyloid beta-peptide ; Alzheimer disease ; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 ; Glycosylation

刊名：Biochemical and Biophysical Research Communications

出版年：2017

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