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内部出版物
SpringerLink电子期刊(53)
Elsevier电子期刊(21)
ACS电子期刊(4)
在“
Elsevier电子期刊
”中,
命中:
21
条,耗时:0.0159897 秒
在所有数据库中总计命中:
78
条
1.
Gamma
secretase
inhibitor
impairs epithelial-to-mesenchymal transition induced by TGF-
β
in ovarian tumor cell lines
作者:
M.C. Pazos
mariacamilapazos@gmail.com
;
D. Abramovich
dnabramovich@gmail.com
;
A. Bechis
andy_bechis@hotmail.com
;
P. Accialini
paccialini@gmail.com
;
F. Parborell
fparborell@gmail.com
;
M. Tesone
martatesone.uba@gmail.com
;
G. Irusta
;
irustag@gmail.com
关键词:
Gamma
secretase
inhibitor
;
Epithelial-to-mesenchymal transition
;
TGF-
β
;
Cadherin switch
;
Metastasis
;
Ovarian cancer
刊名:Molecular and Cellular Endocrinology
出版年:2017
2.
Neuritogenic activity of bi-functional bis-tryptoline triazole
作者:
Jutamas Jiaranaikulwanitch
a
;
b
;
jutamas.jia@cmu.ac.th
;
Sarin Tadtong
c
;
Piyarat Govitrapong
d
;
Valery V. Fokin
e
;
Opa Vajragupta
b
关键词:
Bis-tryptoline triazole
;
Multifunctional activity
;
Neuritogenic activity
;
β
-
secretase
inhibitor
;
β
-amyloid aggregation
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
3.
Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment
作者:
Zuzana Gazova
a
;
gazova@saske.sk
;
Ondrej Soukup
b
;
c
;
d
;
Vendula Sepsova
b
;
c
;
Katarina Siposova
a
;
Lucie Drtinova
c
;
Petr Jost
b
;
c
;
Katarina Spilovska
b
;
c
;
d
;
Jan Korabecny
b
;
c
;
d
;
Eugenie Nepovimova
b
;
c
;
Diana Fedunova
a
;
Martin Horak
e
;
Martina Kaniakova
e
;
Ze-Jun Wang
f
;
Ayman K. Hamouda
f
;
Kamil Kuca
b
;
c
;
d
关键词:
Amyloid
;
Aggregation
;
A
β
peptide
;
Muscarinic/nicotinic acetylcholine receptor antagonist
;
N-Methyl-d-aspartate receptor antagonist
;
β
-
Secretase
inhibitor
;
Alzheimer's disease
刊名:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
出版年:2017
4.
Ginsenoside Rd promotes non-amyloidogenic pathway of amyloid precursor protein processing by regulating phosphorylation of estrogen receptor alpha
作者:
Xiaodong Yan
a
;
1
;
Gengyao Hu
b
;
1
;
Weiming Yan
c
;
1
;
Tao Chen
c
;
e
;
Feng Yang
a
;
d
;
Xiao Zhang
b
;
Gang Zhao
b
;
zhaogang@fmmu.edu.cn
;
Juanfang Liu
c
;
juanfangliu@163.com
关键词:
GS-Rd
;
Alzheimer's disease
;
Amyloid-
β
precursor protein (APP) processing
;
A
β
;
MAPK and PI3K pathway
;
ER
刊名:Life Sciences
出版年:2017
5.
Design and synthesis of water soluble
β
-aminosulfone analogues of SCH 900229 as γ-
secretase
inhibitor
s
作者:
Wen-Lian Wu
a
;
;
Duane A. Burnett
a
;
John Clader
a
;
William J. Greenlee
a
;
Qin Jiang
b
;
Lynn A. Hyde
a
;
Robert A. Del Vecchio
a
;
Mary E. Cohen-Williams
a
;
Lixin Song
a
;
Julie Lee
a
;
Giuseppe Terracina
a
;
Qi Zhang
a
;
Amin Nomeir
a
;
Eric M. Parker
a
;
Lili Zhang
a
关键词:
AD
;
Alzheimer&rsquo
;
s disease
;
A
β
;
β
-amyloid
;
PS1
;
presenilin-1
;
PS2
;
presenilin-2
;
APP
;
amyloid precursor protein
;
GSI
;
γ-
secretase
inhibitor
;
SAR
;
structure&ndash
;
activity relationship
;
ADME
;
absorption
;
distribution
;
metabolism
;
and excretion
;
AUC
;
area under curve
;
mCPBA
;
m-chloroperbenzoic acid
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
6.
Profiling the dynamics of CSF and plasma A
β
reduction after treatment with JNJ-54861911, a potent oral BACE
inhibitor
作者:
Maarten Timmers
a
;
b
;
1
;
Bianca Van Broeck
a
;
1
;
Steven Ramael
c
;
John Slemmon
d
;
Katja De Waepenaert
a
;
Alberto Russu
a
;
Jennifer Bogert
e
;
Hans Stieltjes
a
;
Leslie M. Shaw
f
;
Sebastiaan Engelborghs
b
;
g
;
Dieder Moechars
a
;
Marc Mercken
a
;
Enchi Liu
d
;
Vikash Sinha
h
;
John Kemp
a
;
Luc Van Nueten
a
;
Luc Tritsmans
a
;
Johannes Rolf Streffer
a
;
b
;
jstreffe@its.jnj.com" class="auth_mail" title="E-mail the corresponding author
关键词:
JNJ-54861911
;
Alzheimer's disease
;
Amyloid
β
;
β
-
secretase
enzyme
;
BACE1
;
BACE
inhibitor
s
刊名:Alzheimer's & Dementia: Translational Research & Clinical Interventions
出版年:2016
7.
4-O-galloylalbiflorin discovered from Paeonia lactiflora Pall. is a potential
β
-site amyloid precursor protein cleaving enzyme 1 (BACE1)
inhibitor
作者:
Xiao-Long Hu
a
;
b
;
1
;
Ye-Bo Li
a
;
1
;
Song Qi
b
;
Qiao Zhang
b
;
Tian-Shu Ren
a
;
Wei-Hong Meng
a
;
weihongmeng_edu@163.com
;
Qing-Chun Zhao
a
;
zhaoqingchun1967@163.com
关键词:
Alzheimer's disease (AD)
;
β
-
secretase
(BACE1)
;
β
-amyloid peptide
;
Paeonia lactiflora Pall
;
4-O-galloylalbiflorin
;
Docking
刊名:Journal of Functional Foods
出版年:2016
8.
Pharmacological properties of a novel and potent γ-
secretase
modulator as a therapeutic option for the treatment of Alzheimer’s disease
作者:
Koji Murakami
a
;
Tomomichi Watanabe
a
;
Tatsuki Koike
a
;
Makoto Kamata
a
;
Tomoko Igari
b
;
Shinichi Kondo
a
;
shinichi.kondou@takeda.com" class="auth_mail" title="E-mail the corresponding author
关键词:
A
β
;
Amyloid-
β
;
AD
;
Alzheimer&rsquo
;
s disease
;
APP
;
Amyloid precursor protein
;
β
-CTF
;
β
-C-terminal fragment
;
BACE
;
β
-site APP-cleaving enzyme
;
CSF
;
Cerebrospinal fluid
;
ELISA
;
Enzyme-linked immunosorbent assay
;
FBS
;
Fetal bovine serum
;
GSI
;
γ-
secretase
inhibitor
;
GSM
;
γ-
secretase
modulator
;
LC/MS/MS
;
Liquid chromatography-tandem mass spectrometry
;
N2a-APPsw
;
Neuro-2a mouse neuroblastoma cells stably expressing human Swedish mutant APP
;
NFT
;
Neurofibrillary tangle
;
NORT
;
Novel object recognition t
刊名:Brain Research
出版年:2016
9.
Alzheimer’s therapy targeting the
β
-
secretase
enzyme BACE1: Benefits and potential limitations from the perspective of animal model studies
作者:
Masuo Ohno
a
;
b
;
mohno@nki.rfmh.org" class="auth_mail" title="E-mail the corresponding author
关键词:
Alzheimer&rsquo
;
s disease
;
β
-
Secretase
;
BACE1
;
Learning and memory
;
Synaptic function
;
Mouse model
刊名:Brain Research Bulletin
出版年:2016
10.
Substituted 4-morpholine N-arylsulfonamides as γ-
secretase
inhibitor
s
作者:
Zhiqiang Zhao
a
;
zhiqiang.zhao@merck.com" class="auth_mail" title="E-mail the corresponding author
;
Dmitri A. Pissarnitski
a
;
Hubert B. Josien
a
;
Thomas A. Bara
a
;
John W. Clader
a
;
Hongmei Li
a
;
Mark D. McBriar
a
;
Murali Rajagopalan
a
;
Ruo Xu
a
;
Giuseppe Terracina
b
;
Lynn Hyde
b
;
Lixin Song
b
;
Lili Zhang
b
;
Eric M. Parker
b
;
Rebecca Osterman
c
;
Alexei V. Buevich
c
关键词:
γ-
secretase
inhibitor
;
Alzheimer's disease
;
substituted 4-morpholine sulfonamide
刊名:European Journal of Medicinal Chemistry
出版年:2016
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