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SpringerLink电子期刊(4)
Elsevier电子期刊(27)
ACS电子期刊(3)
在“
Elsevier电子期刊
”中,
命中:
27
条,耗时:小于0.01 秒
在所有数据库中总计命中:
34
条
1.
Arylsulfonamide
inhibitors
of
aggrecanase
s as potential therapeutic agents for osteoarthritis: Synthesis and biological evaluation
作者:
Elisa Nuti
a
;
1
;
Salvatore Santamaria
b
;
c
;
1
;
Francesca Casalini
a
;
Kazuhiro Yamamoto
c
;
Luciana Marinelli
d
;
Valeria La Pietra
d
;
Ettore Novellino
d
;
Elisabetta Orlandini
a
;
Susanna Nencetti
a
;
Anna Maria Marini
a
;
Silvia Salerno
a
;
Sabrina Taliani
a
;
Federico Da Settimo
a
;
Hideaki Nagase
b
;
c
;
Armando Rossello
a
;
aros@farm.unipi.it
关键词:
ADAMTS
-
5
;
ADAMTS
-4
;
Aggrecanase
inhibitors
;
Arylsulfonamido-based hydroxamates
;
Osteoarthritis
刊名:European Journal of Medicinal Chemistry
出版年:
2
013
2.
Discovery of a benzimidazole series of
ADAMTS
-
5
(
aggrecanase
-
2
)
inhibitors
by scaffold hopping
作者:
Shinya Sogame
;
Yoshihito Suenaga
;
Masakazu Atobe
;
Masashi Kawanishi
;
Eiichi Tanaka
;
Shiro Miyoshi
关键词:
ADAMTS
-
5
;
Benzimidazole
;
Thiazolidin-4-one
;
Inhibitor
;
Osteoarthritis
刊名:European Journal of Medicinal Chemistry
出版年:7 January,
2
014
3.
Design, synthesis and SAR investigation of thienosultam derivatives as
ADAMTS
-
5
(
aggrecanase
-
2
)
inhibitors
作者:
Masakazu Atobe
;
atobe.mb@om.asahi-kasei.co.jp
;
Naomi Maekawara
;
Masashi Kawanishi
;
Hiroko Suzuki
;
Eiichi Tanaka
;
Shiro Miyoshi
关键词:
Osteoarthritis
;
Aggrecanase
-
2
;
ADAMTS
-
5
;
Thienosultam
;
S1&prime
;
pocket
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:
2
013
4.
Histone deacetylase
inhibitors
suppress mechanical stress-induced expression of RUNX-
2
and
ADAMTS
-
5
through the inhibition of the MAPK signaling pathway in cultured human chondrocytes
作者:
T. Saito
&dagger
;
;
K. Nishida
&Dagger
;
;
knishida@md.okayama-u.ac.jp
;
T. Furumatsu
&dagger
;
;
A. Yoshida
&dagger
;
;
M. Ozawa
&dagger
;
;
T. Ozaki
&dagger
;
关键词:
Chondrocyte
;
Mechanical stress
;
RUNX-
2
;
Aggrecanase
;
ADAMTS
;
Histone deacetylase inhibitor
刊名:Osteoarthritis and Cartilage
出版年:
2
013
5.
A series of thiazole derivatives bearing thiazolidin-4-one as non-competitive
ADAMTS
-
5
(
aggrecanase
-
2
)
inhibitors
作者:
Masakazu Atobe
;
atobe.mb@om.asahi-kasei.co.jp
;
Naomi Maekawara
;
Noriko Ishiguro
;
Shinya Sogame
;
Yoshihito Suenaga
;
Masashi Kawanishi
;
Hiroko Suzuki
;
Norimasa Jinno
;
Eiichi Tanaka
;
Shiro Miyoshi
关键词:
ADAMTS
-
5
;
Thiazole
;
Thiazolidin-4-one
;
Non-competitive inhibitor
;
Osteoarthritis
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:
2
013
6.
Expression and regulation of metalloproteinases and their
inhibitors
in?intervertebral disc aging and degeneration
作者:
Nam V. Vo
;
PhD
a
;
Robert A. Hartman
;
MS
a
;
b
;
Takashi Yurube
;
MD
;
PhD
a
;
c
;
Lloydine J. Jacobs
;
MD
a
;
Gwendolyn A. Sowa
;
MD
;
PhD
a
;
b
;
James D. Kang
;
MD
a
;
kangjd@upmc.edu
关键词:
Intervertebral disc degeneration
;
Extracellular matrix
;
MMPs
;
ADAMTS
;
Aging
刊名:The Spine Journal
出版年:
2
013
7.
Mechanisms involved in suppression of
ADAMTS
4 expression in synoviocytes by high molecular weight hyaluronic acid
作者:
Yoshihiro Kataoka
a
;
b
;
Wataru Ariyoshi
a
;
Toshinori Okinaga
a
;
Takeshi Kaneuji
b
;
Sho Mitsugi
b
;
Tetsu Takahashi
c
;
Tatsuji Nishihara
a
;
tatsujin@kyu-dent.ac.jp
关键词:
ADAMTS
4
;
Synoviocyte
;
Hyaluronan
;
CD44
;
p38 MAPK
;
JNK
刊名:Biochemical and Biophysical Research Communications
出版年:
2
013
8.
Celecoxib exerts protective effects on extracellular matrix metabolism of mandibular condylar chondrocytes under excessive mechanical stress
作者:
S.-C. Su
;
K. Tanimoto
;
tkotaro@hiroshima-u.ac.jp" class="auth_mail
;
Y. Tanne
;
R. Kunimatsu
;
N. Hirose
;
T. Mitsuyoshi
;
Y. Okamoto
;
K. Tanne
关键词:
Chondrocyte
;
Mechanical stress
;
Celecoxib
;
Extracellular matrix
;
Matrix metalloproteinases
刊名:Osteoarthritis and Cartilage
出版年:June
2
014
9.
Structure
2
013;activity study on a series of α-glutamic acid scaffold based compounds as new
ADAMTS
inhibitors
作者:
Lijie Peng
a
;
b
;
Lei Duan
a
;
Xiaofeng Liu
c
;
Mengjie Shen
a
;
b
;
Yingjun Li
a
;
b
;
Jiajie Yan
a
;
b
;
Honglin Li
c
;
Ke Ding
a
;
ding_ke@gibh.ac.cn"" rel=""nofollow
关键词:
Osteoarthritis
;
Aggrecanase
;
ADAMTS
;
Glutamic acid scaffold
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:
2
011
10.
Synthesis and SAR of
2
-phenyl-1-sulfonylaminocyclopropane carboxylates as
ADAMTS
-
5
(
Aggrecanase
-
2
)
inhibitors
作者:
Makoto Shiozaki
;
Hiroto Imai
;
Katsuya Maeda
;
Tomoya Miura
;
Katsutaka Yasue
;
Akira Suma
;
Masahiro Yokota
;
Yosuke Ogoshi
;
Julia Haas
;
Andrew M. Fryer
;
Ellen R. Laird
;
Nicole M. Littmann
;
Steven W. Andre
关键词:
SAR
;
ADAMTS
-
5
(
Aggrecanase
-
2
)
inhibitors
;
2
-Phenyl-1-sulfonylaminocyclopropanecarboxylates
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:
2
009
1
2
3
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