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Elsevier电子期刊(163)

在“Elsevier电子期刊”中，命中：163条，耗时：0.0179944 秒

在所有数据库中总计命中：288条

1.Gut microbiome interactions with drug metabolism, efficacy, and toxicity

作者：Ian D. Wilson ; ^{ianwilsonprof@gmail.com} ; Jeremy K. Nicholson

关键词：ADMET ; absorption ; distribution ; metabolism ; excretion ; toxicity ; AHR ; aryl hydrocarbon receptor ; AUC ; area under the curve ; BVU ; (E)-5-(2-bromovinyl) uracil ; CAR ; constitutive androstane receptor ; cMOAT ; Canalicular multispecific organic anion transporter 1 ; cgr ; cardiac glycoside reductase ; CYP450s ; cytochromes P450 ; DPD ; dihydropyrimidine dehydrogenase ; DNA ; deoxyribonucleic acid ; EPHXs ; epoxide hydrolases ; DMI&rsquos ; drug-microbiome interactions ; FDA ; Food and Drug Administration ; GF ; germ

刊名：Translational Research

出版年：2017

2.Use of read-across to simplify the toxicological assessment of a complex mixture of lysimeter leachate metabolites on the basis of chemical similarity and ADME behavior

作者：Laurence H. Hand ; ^{laurence.hand@syngenta.com} ; Kevan Richardson ; Stephen T. Hadfield ; Sarah Whalley ; Paul Rawlinson ; Ewan D. Booth

关键词：Lysimeter ; S-metolachlor ; ADME ; Relevance ; Read-across

刊名：Regulatory Toxicology and Pharmacology

出版年：2017

3.Antitubercular activity of 1,2,3-triazolyl fatty acid derivatives

作者：Diego G. Ghiano^a ; Agustina de la Iglesia^b ; Nina Liu^c ; Peter J. Tonge^c ; Hé ; ctor R. Morbidoni^d ; ^e ; Guillermo R. Labadie^a ; ^f ; ^{labadie@iquir-conicet.gov.ar}

关键词：12 ; 3-triazoles ; Tuberculosis ; Resistant strains ; Parallel solution synthesis ; SAR ; ADME-tox

刊名：European Journal of Medicinal Chemistry

出版年：2017

4.γ-Cyclodextrin

作者：Phennapha Saokham ; Thorsteinn Loftsson ; ^{thorstlo@hi.is}

关键词：γ-Cyclodextrin ; ADME ; Complexing agent ; Inclusion complex ; Solubilization ; Aggregation

刊名：International Journal of Pharmaceutics

出版年：2017

5.Design, synthesis and biological evaluation of novel 3-substituted 4-anilino-coumarin derivatives as antitumor agents

作者：Guoshun Luo^a ; ^b ; Moses Muyaba^a ; ^b ; Weiting Lyu^b ; Zhichao Tang^a ; ^b ; Ruheng Zhao^b ; Qian Xu^b ; Qidong You^a ; ^b ; Hua Xiang^a ; ^b ; ^{xianghua@cpu.edu.cn}

关键词：Coumarin derivatives ; Synthesis ; Antitumor ; Apoptosis ; Selectivity index

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

6.Molecular docking, discovery, synthesis, and pharmacological properties of new 6-substituted-2-(3-phenoxyphenyl)-4-phenyl quinoline derivatives; an approach to developing potent DNA gyrase inhibitors/antibacterial agents

作者：Manikandan Alagumuthu ; Sivakumar Arumugam ; ^{mailtomicromani@gmail.com}

关键词：Phenoxyphenyl quinolines ; Antibacterial ; DNA gyrase A ; Molecular docking ; Drug discovery

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

7.Synthesis, ADME studies, toxicity estimation, and exploration of molecular recognition of thiophene based chalcones towards monoamine oxidase-A and B

作者：Bijo Mathew^a ; ^{bijovilaventgu@gmail.com} ; Jerad Suresh^b ; Githa Elizabeth Mathew^c ; Abitha Haridas^c ; Geethu Suresh^c ; P. Sabreena^c

关键词：2-Acetly thiophene ; Chalcone ; AutoDock ; Molecular docking

刊名：Beni-Suef University Journal of Basic and Applied Sciences

出版年：2016

8.High-throughput virtual screening and quantum mechanics approach to develop imipramine analogues as leads against trypanothione reductase of leishmania

作者：Rajan Kumar Pandey^a ; Parmila Verma^a ; Drista Sharma^b ; Tarun Kumar Bhatt^b ; Shyam Sundar^c ; Vijay Kumar Prajapati^a ; ^{vkprajapati@curaj.ac.in" class="auth_mail" title="E-mail the corresponding author} ; ^{vijay84bhu@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Imipramine ; Molecular dynamics ; Trypanothione reductase ; Visceral leishmaniasis ; ADMET

刊名：Biomedicine & Pharmacotherapy

出版年：2016

9.In-silico analysis of gymnemagenin from Gymnema sylvestre (Retz.) R.Br. with targets related to diabetes

作者：Poonam K. Rathore^a ; ^b ; V. Arathy^a ; Vijaylaxmi S. Attimarad^a ; Pramod Kumar^a ; Subarna Roy^a ; ^{drsubarnaroy@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; ^{roys@icmr.org.in" class="auth_mail" title="E-mail the corresponding author}

关键词：Docking ; Autodock ; ADMET ; Ligand

刊名：Journal of Theoretical Biology

出版年：2016

10.Cytochrome P450 expression system for high-throughput real-time detection of genotoxicity: Application to the study of human CYP1A2 variants

作者：Bernardo Brito Palma^a ; Daniela Moutinho^a ; ¹ ; Philippe Urban^b ; ^c ; ^d ; José ; Rueff^a ; Michel Kranendonk^a ; ^{michel.kranendonk@fcm.unl.pt" class="auth_mail" title="E-mail the corresponding author}

关键词：1AP ; 1-aminopyrene ; 2AA ; 2-aminoanthracene ; ADMET ; absorption ; distribution ; metabolism ; excretion and toxicity ; ADR ; adverse drug reaction ; CPR ; cytochrome P450 oxidoreductase ; δ-Ala ; δ-aminolevulinic acid ; DMEs ; drug metabolizing enzymes ; FI ; Induction Factor ; FP ; fluorescent protein ; GFP ; green fluorescent protein ; HT ; high-throughput ; IPTG ; isopropyl β-d-thiogalactopyranoside ; IQ ; 2-amino-3-methylimidazo(4 ; 5-f)quinoline ; MDS ; multidimensional scaling ; PCA ; principal component analysis ; RMs

刊名：Mutation Research/Genetic Toxicology and Environmental Mutagenesis

出版年：2016

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