搜索页_+BBB+permeability

设为首页

收藏本站

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Readers' Guide

Opening Hours
Collections
Help Via Email

Publications

Electronic Information Resources

外文资源

Wiley电子期刊(11)	NATURE电子期刊(2)	ACS电子期刊(54)
SpringerLink电子期刊(340)	Elsevier电子期刊(854)

在“Elsevier电子期刊”中，命中：854条，耗时：小于0.01 秒

在所有数据库中总计命中：1,261条

1.Assessment of the Blood-Brain Barrier Permeability of Potential Neuroprotective Aurones in Parallel Artificial Membrane Permeability Assay and Porcine Brain Endothelial Cell Models

作者：Kok-Fui Liew¹ ; Nur Aziah Hanapi² ; Kit-Lam Chan¹ ; Siti R. Yusof² ; Chong-Yew Lee¹ ; ^{chongyew@usm.my}

关键词：blood-brain barrier ; permeability ; in vitro models ; CNS ; drug-like properties ; drug design

刊名：Journal of Pharmaceutical Sciences

出版年：2017

2.Electroconvulsive stimulation transiently enhances the permeability of the rat blood-brain barrier and induces astrocytic changes

作者：Masanobu Ito^a ; ^{masa110@juntendo.ac.jp} ; Kuerban Bolati^a ; ^b ; ^c ; Tomoya Kinjo^a ; Koichiro Ichimura^d ; Akiko Furuta^a ; Declan M. McLoughlin^e ; ^f ; Toshihito Suzuki^a ; Heii Arai^a

关键词：Depression ; ECT ; BBB ; Astrocyte ; Tight junction ; Neurovascular unit

刊名：Brain Research Bulletin

出版年：2017

3.BBB penetration-targeting physicochemical lead selection: Ecdysteroids as chemo-sensitizers against CNS tumors

作者：Judit Mü ; ller^a ; Ana Martins^b ; ¹ ; Jó ; zsef Csá ; bi^c ; Ferenc Fenyvesi^d ; Á ; rpá ; d Kö ; nczö ; l^a ; Attila Hunyadi^c ; ^e ; ^{hunyadi.a@pharm.u-szeged.hu} ; Gyö ; rgy T. Balogh^a ; ^{gy.balogh@richter.hu}

关键词：PAMPA-BBB ; Physicochemical profiling ; Lead selection ; Ecdysteroid ; Cancer ; Adjuvant ; Chemo-sensitization

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

4.HDM-PAMPA to predict gastrointestinal absorption, binding percentage, equilibrium and kinetics constants with human serum albumin and using 2 end-point measurements

作者：Alban Bujard¹ ; Charlotte Petit¹ ; Pierre-Alain Carrupt ; Serge Rudaz ; Julie Schappler ; ^{julie.schappler@unige.ch}

关键词：Passive permeability ; PAMPA ; Gastrointestinal tract absorption ; Binding percentage ; Dissociation/association constants ; Dissociation/association microconstants ; Human serum albumin

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

5.Anti-excitotoxic effects of cannabidiol are partly mediated by enhancement of NCX2 and NCX3 expression in animal model of cerebral ischemia

作者：Sepideh Khaksar ^{sepieh.khaksar@gmail.com} ; Mohammad Reza Bigdeli ; ^{bigdelimohammadreza@yahoo.com}

关键词：Cannabidiol (PubChem CID ; 26346) ; Dimethyl Sulfoxide (PubChem CID ; 679) ; 23 ; 5-triphenyltetrazolium Chloride (PubChem CID ; 9283) ; Evans Blue Dye (PubChem CID ; 24832074) ; Trichloroacetic acid (PubChem CID ; 6421)

刊名：European Journal of Pharmacology

出版年：2017

6.Curcumin attenuates blood-brain barrier disruption after subarachnoid hemorrhage in mice

作者：Jichao Yuan ; MD¹ ; Wei Liu ; MD¹ ; Haitao Zhu ; MD ; Xuan Zhang ; MD ; Yang Feng ; MD ; Yaxing Chen ; MD ; Hua Feng ; MD ; Jiangkai Lin ; MD ; ^{jklin@tmmu.edu.cn}

关键词：Blood-brain barrier ; Curcumin ; Early brain injury ; Subarachnoid hemorrhage

刊名：Journal of Surgical Research

出版年：2017

7.Rapid and efficient crossing blood-brain barrier: Hydrophobic drug delivery system based on propionylated amylose helix nanoclusters

作者：Wei Gao^a ; ^b ; ¹ ; Yongchun Liu^b ; ¹ ; Guixia Jing^a ; Ke Li^b ; Yuan Zhao^a ; Baoyong Sha^c ; ^{shabaoyong@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Qiang Wang^a ; ^{dr.wangqiang@139.com" class="auth_mail" title="E-mail the corresponding author} ; Daocheng Wu^b ; ^{wudaocheng@mail.xjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：Amylose helix ; Nanoclusters ; Triggered release ; Blood-brain barrier ; Sedative effects

刊名：Biomaterials

出版年：2017

8.Multitarget drug design strategy against Alzheimer’s disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties

作者：Yan Li^a ; Xiaoming Qiang^a ; Li Luo^a ; Xia Yang^a ; Ganyuan Xiao^a ; Yunxiaozhu Zheng^a ; Zhongcheng Cao^a ; Zhipei Sang^b ; Fu Su^a ; ^{sufu@scu.edu.cn} ; Yong Deng^a ; ^{dengyong@scu.edu.cn}

关键词：Alzheimer&rsquo ; s disease ; Homoisoflavonoid ; Mannich base derivatives ; Acetylcholinesterase inhibitors ; Monoamine oxidase B inhibitors ; Multifunctional properties

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

9.Crystal structures, binding interactions, and ADME evaluation of brain penetrant N-substituted indazole-5-carboxamides as subnanomolar, selective monoamine oxidase B and dual MAO-A/B inhibitors

作者：Nikolay T. Tzvetkov^a ; ^{ntzvetkov@ntzlab.com} ; Hans-Georg Stammler^b ; Beate Neumann^b ; Silvia Hristova^c ; Liudmil Antonov^c ; Marcus Gastreich^d

关键词：ADME ; MAO inhibitors ; Molecular modeling ; Indazole-5-carboxamides ; Parkinson's disease ; X-ray

刊名：European Journal of Medicinal Chemistry

出版年：2017

10.In vitro blood-brain barrier permeability predictions for GABA_A receptor modulating piperine analogs

作者：Daniela Elisabeth Eigenmann^a ; Carmen Dü ; rig^a ; Evelyn Andrea Jä ; hne^a ; Martin Smie&scaron ; ko^b ; Maxime Culot^c ; Fabien Gosselet^c ; Romeo Cecchelli^c ; Hans Christian Cederberg Helms^d ; Birger Brodin^d ; Laurin Wimmer^e ; Marko D. Mihovilovic^e ; Matthias Hamburger^a ; Mouhssin Oufir^a ; ^{mouhssin.oufir@unibas.ch" class="auth_mail" title="E-mail the corresponding author}

关键词：BBB ; blood&ndash ; brain barrier ; BLEC ; human brain-like endothelial cells ; BSA ; bovine serum albumin ; CCL ; cell layer capacitance ; CNS ; central nervous system ; CV ; coefficient of variation ; DMEM ; Dulbecco&rsquo ; s Modified Eagle Medium ; ER ; efflux ratio ; FA ; formic acid ; FBS ; fetal bovine serum ; GABAA receptor ; γ-aminobutyric acid type A receptor ; hBMEC ; human brain microvascular endothelial cell line ; I.S. ; internal standard ; LLOQ ; lower limit of quantification ; MRM ; multiple reaction monitoring

刊名：European Journal of Pharmaceutics and Biopharmaceutics

出版年：2016

按检索点细分(854)

题名(22)

关键词(38)

文摘(742)

按出版年细分(854)

2027年及以后(26)

2017年(9)

2016年(77)

2015年(18)

2013年(55)

2012年(66)

2011年(53)

2010年(52)

2009年(42)

2008年(41)

2007年(35)

2006年(38)

2005年(33)

2004年(46)

2003年(31)

2002年(36)

2001年(28)

2000年(21)

2000年及以前(147)