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Elsevier电子期刊(454)
在“
Elsevier电子期刊
”中,
命中:
454
条,耗时:小于0.01 秒
在所有数据库中总计命中:
454
条
1.
Design and synthesis of phosphoryl-substituted diphenylpyrimidines (Pho-DPPYs) as potent Bruton’s tyrosine kinase (
BTK
) inhibitors: Targeted treatment of B lymphoblastic leukemia cell lines
作者:
Yang Ge
a
;
1
;
Haijun Yang
a
;
1
;
Changyuan Wang
a
;
Qiang Meng
a
;
Lei Li
a
;
Huijun Sun
a
;
Yuhong Zhen
a
;
Kexin Liu
a
;
Yanxia Li
b
;
Xiaodong Ma
a
;
xiaodong.ma@139.com
关键词:
Leukemia
;
BTK
;
DPPY
;
Phosphoryl
;
Inhibitor
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
2.
Structural optimization of diphenylpyrimidine derivatives (DPPYs) as potent Bruton's tyrosine kinase (
BTK
) inhibitors with improved activity toward B leukemia cell lines
作者:
Dan Zhao
a
;
Shanshan Huang
a
;
Menghua Qu
a
;
Changyuan Wang
a
;
Zhihao Liu
a
;
Zhen Li
a
;
Jinyong Peng
a
;
Kexin Liu
a
;
Yanxia Li
b
;
Xiaodong Ma
a
;
xiaodong.ma@139.com
;
Xiaohong Shu
a
;
xiaohong_shu@dmu.edu.cn
关键词:
Leukemia
;
BTK
;
Pyrimidine
;
Synthesis
;
Inhibitor
刊名:European Journal of Medicinal Chemistry
出版年:2017
3.
Mitigation of reactive metabolite formation for a series of 3-amino-2-pyridone inhibitors of Bruton’s tyrosine kinase (
BTK
)
作者:
Yan Lou
;
yan.lou@gmail.com
;
Francisco Lopez
;
Yongying Jiang
;
Xiaochun Han
;
Chris Brotherton
;
Roland Billedeau
;
Steve Gabriel
;
Shelly Gleason
;
David M. Goldstein
;
Ramona Hilgenkamp
;
Buelent Kocer
;
Lucja Orzechowski
;
Jenny Tan
;
Peter Wovkulich
;
Bo Wen
;
David Fry
;
Paola Di Lello
;
Lucy Chen
;
Fang-jie Zhang
;
Jennifer Fretland
;
Anjali Nangia
;
Tian Yang
;
Timothy D. Owens
关键词:
Bruton&rsquo
;
s tyrosine kinase
;
BTK
;
Reactive metabolite
;
Covalent binding
;
Glutathione adduct
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2017
4.
Epstein-Barr Virus Latent Membrane Protein 2A (LMP2A) enhances IL-10 production through the activation of Bruton's tyrosine kinase and STAT3
作者:
Ryan Incrocci
a
;
Levi Barse
b
;
Amanda Stone
a
;
Sai Vagvala
a
;
Michael Montesano
a
;
Vijay Subramaniam
b
;
Michelle Swanson-Mungerson
a
;
mswans@midwestern.edu
关键词:
B cell
;
Epstein-Barr virus
;
Latent Membrane Protein 2A
;
Interleukin-10
;
Bruton's tyrosine kinase (
BTK
)
;
Signal Transducer and Activator of Transcription 3 (STAT3)
刊名:Virology
出版年:2017
5.
Compound Selectivity and Target Residence Time of Kinase Inhibitors Studied with Surface Plasmon Resonance
作者:
Nicole Willemsen-Seegers
1
;
Joost C.M. Uitdehaag
1
;
Martine B.W. Prinsen
1
;
Judith R.F. de Vetter
1
;
Jos de Man
1
;
Masaaki Sawa
2
;
Yusuke Kawase
2
;
Rogier C. Buijsman
1
;
Guido J.R. Zaman
1
;
guido.zaman@ntrc.nl
关键词:
FDA
;
US Food and Drug Administration
;
EGFR
;
epidermal growth factor receptor
;
BTK
;
Bruton's tyrosine kinase
;
SPR
;
surface plasmon resonance
;
PI3K
;
phosphoinositide 3-kinase
;
SD
;
standard deviation
;
SE
;
standard error
;
PI3K
;
phosphoinositide 3-kinase
;
SPR
;
surface plasmon resonance
刊名:Journal of Molecular Biology
出版年:2017
6.
Btk
inhibition treats TLR7/IFN driven murine lupus
作者:
Andrew T. Bender
a
;
Andrew.bender@emdserono.com" class="auth_mail" title="E-mail the corresponding author
;
Albertina Pereira
a
;
Kai Fu
a
;
Eileen Samy
a
;
Yin Wu
a
;
Lesley Liu-Bujalski
b
;
Richard Caldwell
b
;
Yi-Ying Chen
b
;
Hui Tian
b
;
Federica Morandi
c
;
Jared Head
c
;
Ursula Koehler
d
;
Melinda Genest
a
;
Shinji L. Okitsu
a
;
Daigen Xu
a
;
Roland Grenningloh
a
关键词:
Btk
;
Bruton's tyrosine kinase
;
TLR7
;
Toll-like receptor 7
;
BCR
;
B cell receptor
;
FcR
;
Fc receptor
;
SLE
;
systemic lupus erythematosus
;
IFN
;
interferon
;
FACS
;
fluorescence-activated cell sorting
;
MMF
;
mycophenolate mofetil
刊名:Clinical Immunology
出版年:2016
7.
The Neutrophil
Btk
Signalosome Regulates Integrin Activation during Sterile Inflammation
作者:
Stephanie Volmering
1
;
3
;
Helena Block
1
;
3
;
Mark Boras
1
;
Clifford A. Lowell
2
;
Alexander Zarbock
1
;
zarbock@uni-muenster.de" class="auth_mail" title="E-mail the corresponding author
关键词:
Btk
;
fMLF
;
Src family kinases
;
phospholipase C
;
WASp
;
signaling
;
integrin
刊名:Immunity
出版年:2016
8.
Liquid chromatography-tandem mass spectrometric assay for the simultaneous determination of the irreversible
BTK
inhibitor ibrutinib and its dihydrodiol-metabolite in plasma and its application in mouse pharmacokinetic studies
作者:
Johannes J.M. Rood
a
;
j.j.m.rood@uu.nl" class="auth_mail" title="E-mail the corresponding author
;
Stephanie van Hoppe
b
;
Alfred H. Schinkel
b
;
Jan H.M. Schellens
a
;
c
;
Jos H. Beijnen
a
;
c
;
d
;
Rolf W. Sparidans
a
关键词:
BCR
;
B-cell antigen receptor
;
BSA
;
bovine serum albumin
;
BTK
;
Bruton&rsquo
;
s tyrosine kinase
;
CHMP
;
Committee for Medicinal Products for Human Use
;
DHI
;
dhihydrodiol-ibrutinib
;
DMSO
;
dimethyl Sulphoxide
;
EMA
;
European Medicines Agency
;
ErbB2
;
receptor tyrosine-protein kinase erbB-2
;
ESI
;
electro spray ionization
;
FDA
;
Food and Drug Administration
;
LC&ndash
;
MS/MS
;
liquid chromatography&ndash
;
tandem mass spectrometry
;
LLOQ
;
lower limit of quantitation
;
MRP1
;
multidrug resistance protein 1
;
PP
;
pol
刊名:Journal of Pharmaceutical and Biomedical Analysis
出版年:2016
9.
Ibrutinib inhibition of Bruton protein-tyrosine kinase (
BTK
) in the treatment of B cell neoplasms
作者:
Robert Roskoski Jr.
rrj@brimr.org" class="auth_mail" title="E-mail the corresponding author
关键词:
AS
;
activation segment
;
CLL
;
chronic lymphocytic leukemia
;
CS or C-spine
;
catalytic spine
;
CL
;
catalytic loop
;
HΦ or Φ
;
hydrophobic
;
IP3
;
inositol 1
4 ;
5 trisphosphate
;
IP6
;
inositol 1
2345 ;
6 hexakisphosphate
;
MCL
;
mantle cell lymphoma
;
MW
;
molecular weight
;
NSCLC
;
non-small cell lung cancer
;
PKA
;
protein kinase A
;
PIP2
;
phosphatidyl inositol 4
;
5 bisphosphate
;
PIP3
;
phosphatidyl inositol 3
4 ;
5 trisphosphate
;
RA
;
rheumatoid arthritis
;
RS or R-spine
;
regulatory spine
;
Sh1
;
shell residue 1
;
WM
;
W
刊名:Pharmacological Research
出版年:2016
10.
Nonreceptor tyrosine kinases ITK and
BTK
negatively regulate mast cell proinflammatory responses to lipopolysaccharide
作者:
Weishan Huang
;
PhD
a
;
J. Luis Morales
;
PhD
b
;
Victor P. Gazivoda
;
BS
a
;
Avery August
;
PhD
a
;
averyaugust@cornell.edu" class="auth_mail" title="E-mail the corresponding author
关键词:
Tec
;
lipopolysaccharide
;
mast cell
;
septic hypothermia
;
TNF-α
;
NF-κB
;
MAPKs
;
PI3K/Akt
刊名:Journal of Allergy and Clinical Immunology
出版年:2016
1
2
3
4
5
6
7
8
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