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Elsevier电子期刊(184)
在“
Elsevier电子期刊
”中,
命中:
184
条,耗时:小于0.01 秒
在所有数据库中总计命中:
184
条
1.
Discovery of new hit-molecules targeting Plasmodium falciparum through a global SAR study of the 4-substituted-2-trichloromethylquinazoline antiplasmodial scaffold
作者:
Justine Desroches
a
;
1
;
Charline Kieffer
a
;
1
;
Nicolas Primas
a
;
Sé
;
bastien Hutter
b
;
Armand Gellis
a
;
Hussein El-Kashef
c
;
Pascal Rathelot
a
;
Pierre Verhaeghe
d
;
pierre.verhaeghe@univ-tlse3.fr
;
Nadine Azas
b
;
Patrice Vanelle
a
;
patrice.vanelle@univ-amu.fr
关键词:
Quinazoline
;
Quinoline
;
Quinoxaline
;
Thienopyrimidine
;
Trichloromethyl goup
;
Plasmodium falciparum
;
In vitro antiplasmodial activity
;
In vitro HepG2 cytotoxicity
;
Structure-activity relationships
刊名:European Journal of Medicinal Chemistry
出版年:2017
2.
Benzimidazolone
bioisosteres
of potent GluN2B selective NMDA receptor antagonists
作者:
Ines Lü
;
tnant
a
;
Dirk Schepmann
a
;
Bernhard Wü
;
nsch
a
;
b
;
wuensch@uni-muenster.de" class="auth_mail" title="E-mail the corresponding author
关键词:
NMDA antagonists
;
GluN2B selective
;
Benzimidazolone
bioisosteres
;
Tricyclic benzo[7]annulenamines
;
Receptor selectivity
刊名:European Journal of Medicinal Chemistry
出版年:2016
3.
Systematic evaluation of methyl ester
bioisosteres
in the context of developing alkenyldiarylmethanes (ADAMs) as non-nucleoside reverse transcriptase inhibitors (NNRTIs) for anti-HIV-1 chemotherapy
作者:
Ayako Hoshi
a
;
Takeshi Sakamoto
a
;
sakamoto@josai.ac.jp" class="auth_mail" title="E-mail the corresponding author
;
Jun Takayama
a
;
Meiyan Xuan
a
;
Mari Okazaki
a
;
Tracy L. Hartman
b
;
Robert W. Buckheit Jr.
b
;
Christophe Pannecouque
c
;
Mark Cushman
d
;
cushman@purdue.edu" class="auth_mail" title="E-mail the corresponding author
关键词:
ADAM
;
alkenyldiarylmethane
;
NNRTI
;
non-nucleoside reverse transcriptase inhibitor
;
RT
;
reverse transcriptase
;
HIV-1
;
human immunodeficiency virus type 1
;
AIDS
;
acquired immune deficiency syndrome
;
ART
;
antiretroviral therapy
;
NRTI
;
nucleoside reverse transcriptase inhibitor
;
PI
;
protease inhibitor
;
INI
;
integrase inhibitors
;
FI
;
fusion inhibitor
;
CCR5I
;
CC chemokine receptor inhibitor
;
dNTPs
;
deoxynucleoside triphosphate
;
AZT
;
azidothymidine (zidovudine)
;
EDCI
;
1-(3-dimethylaminopropyl)-3-ethylc
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
4.
LAT1 activity of carboxylic acid
bioisosteres
: Evaluation of hydroxamic acids as substrates
作者:
Arik A. Zur
a
;
riko.zur@gmail.com" class="auth_mail" title="E-mail the corresponding author
;
Huan-Chieh Chien
a
;
Evan Augustyn
b
;
Andrew Flint
b
;
Nathan Heeren
b
;
Karissa Finke
b
;
Christopher Hernandez
b
;
Logan Hansen
b
;
Sydney Miller
b
;
Lawrence Lin
a
;
Kathleen M. Giacomini
a
;
Claire Colas
c
;
d
;
Avner Schlessinger
c
;
d
;
Allen A. Thomas
b
;
thomasaa@unk.edu" class="auth_mail" title="E-mail the corresponding author
关键词:
SLC7A5
;
Amino acid
;
Acyl sulfonamide
;
Tetrazole
;
Transporter substrate
;
Transporter inhibitor
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
5.
New peptide deformylase inhibitors design, synthesis and pharmacokinetic assessment
作者:
Fengping Lv
a
;
Chen Chen
a
;
Yang Tang
a
;
Jianhai Wei
a
;
Tong Zhu
b
;
tongzhu@chem.ecnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
;
Wenhao Hu
a
;
whu@chem.ecnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
关键词:
PDF inhibitor
;
Antibacterial drug
;
Antibiotics resistance
;
MRSA
;
Docking study
;
Amide
bioisosteres
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
6.
Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of replacement of the 3-hydroxyphenyl group with pyridine or thiophene
bioisosteres
作者:
Chad M. Kormos
;
Moses G. Gichinga
;
Scott P. Runyon
;
James B. Thomas
;
S. Wayne Mascarella
;
Ann M. Decker
;
Herná
;
n A. Navarro
;
F. Ivy Carroll
;
fic@rti.org" class="auth_mail" title="E-mail the corresponding author
关键词:
[35S]GTPγS
;
sulfur-35 guanosine-5&prime
;
-O-(3-thio)triphosphate
;
DAMGO
;
[D-Ala2
;
MePhe4
;
Gly-ol5]enkephalin
;
DPDPE
;
[D-Pen2
;
D-Pen5]enkephalin
;
U69
;
593
;
(5α
;
7α
;
8β)-(&minus
;
)-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4
;
5]dec-8-yl]benzeneacetamide
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
7.
Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors
作者:
Dmitri A. Pissarnitski
a
;
;
Zhiqiang Zhao
a
;
David Cole
a
;
Wen-Lian Wu
a
;
Martin Domalski
a
;
John W. Clader
a
;
Giovanna Scapin
b
;
Johannes Voigt
b
;
&dagger
;
;
Aileen Soriano
c
;
Theresa Kelly
c
;
Mary Ann Powles
d
;
Zuliang Yao
d
;
Duane A. Burnett
a
;
&Dagger
;
关键词:
Bioisosteres
;
Tricyclic guanine
;
DPP4 inhibitor
;
FAP inhibitor
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
8.
Novel 1,2,4-oxadiazoles and trifluoromethylpyridines related to natural products: synthesis, structural analysis and investigation of their antitumor activity
作者:
Catalin V. Maftei
a
;
d
;
Elena Fodor
a
;
d
;
Peter G. Jones
a
;
Constantin G. Daniliuc
a
;
M. Heiko Franz
b
;
d
;
Gerhard Kelter
c
;
Heinz-Herbert Fiebig
c
;
Matthias Tamm
a
;
Ion Neda
a
;
d
;
i.neda@tu-bs.de" class="auth_mail" title="E-mail the corresponding author
关键词:12 ;
4-Oxadiazoles
;
Anti-tumor activity
;
Pyrazoles
;
Pyrazolo[3
;
4-d]pyrimidine
;
Trifluoromethylpyridine
;
Bioisosteres
刊名:Tetrahedron
出版年:2016
9.
Rapid and straightforward transesterification of sulfonyl carbamates
作者:
Rebecka Isaksson
a
;
Ilze Kumpiņa
a
;
Mats Larhed
b
;
Johan Wannberg
b
;
johan.wannberg@scilifelab.uu.se" class="auth_mail" title="E-mail the corresponding author
关键词:
Sulfonyl carbamates
;
O-alkyl exchange
;
Transesterification
;
Carboxylic acid
bioisosteres
;
AT2R ligand
刊名:Tetrahedron Letters
出版年:2016
10.
Medicinal attributes of pyrazolo[1,5-a]pyrimidine based scaffold derivatives targeting kinases as anticancer agents
作者:
Nasser S.M. Ismail
a
;
b
;
saadnasser2003@yahoo.com
;
Ghada M.E. Ali
c
;
Diaa A. Ibrahim
c
;
Amira M. Elmetwali
c
关键词:
Protein kinase
;
Bioisostere
;
Pyrazolo[1
;
5-a]pyrimidine
;
Anticancer
刊名:Future Journal of Pharmaceutical Sciences
出版年:2016
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