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Springer电子图书(1)
SpringerLink电子期刊(1)
Elsevier电子期刊(9)
ACS电子期刊(8)
在“
Elsevier电子期刊
”中,
命中:
9
条,耗时:小于0.01 秒
在所有数据库中总计命中:
19
条
1.
Discovery and development of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists for the treatment of diabetes
作者:
Jonathan E. Wilson
;
jonathan_wilson@merck.com" class="auth_mail" title="E-mail the corresponding author
;
Ravi Kurukulasuriya
;
Christopher Sinz
;
Matthew Lombardo
;
Kate Bender
;
Dann Parker
;
Edward C. Sherer
;
Melissa Costa
;
Karen Dingley
;
Xiaofang Li
;
Stanley Mitelman
;
Sharon Tong
;
Randal Bugianesi
;
Anka Ehrhardt
;
Birgit
Priest
;
Kevin Ratliff
;
Feroze Ujjainwalla
;
Ravi Nargund
;
William K. Hagmann
;
Scott Edmondson
关键词:
GPR142
;
g-protein coupled receptor 142
;
HTS
;
high throughput screen
;
PPB
;
plasma protein binding
;
CYP
;
cytochrome P450
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
2.
Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one
作者:
Haifeng Tang
;
Reynald K. de Jesus
;
Shawn P. Walsh
;
Yuping Zhu
;
Yan Yan
;
Birgit
T.
Priest
;
Andrew M. Swensen
;
Magdalena Alonso-Galicia
;
John P. Felix
;
Richard M. Brochu
;
Timothy Bailey
;
Br
;
e Thomas-Fowlkes
;
Xiaoyan Zhou
;
Lee-Yuh Pai
;
Caryn Hampton
;
Melba Hern
;
ez
;
Karen Owens
;
Sophie Roy
;
Gregory J. Kaczorowski
;
Lihu Yang
;
et al.
关键词:
ROMK
;
Hypertension
;
Heart failure
;
Diuresis
;
Natriuresis
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2013
3.
Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers
作者:
Sriram Tyagarajan
;
Prasun K. Chakravarty
;
Bishan Zhou
;
Michael H. Fisher
;
Mathew J. Wyvratt
;
Kathy Lyons
;
Tracy Klatt
;
Xiaohua Li
;
Sanjeev Kumar
;
Br
;
e Williams
;
John Felix
;
Birgit
T.
Priest
;
Richard M
关键词:
Neuropathic pain
;
Voltage-gated sodium channel
;
Na
v
1.7 blockers
;
Biaryl oxazoles
;
Biaryl imidazoles
;
Biaryl thiazoles
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2010
4.
Discovery of a novel class of isoxazoline voltage gated sodium channel blockers
作者:
Pengcheng P. Shao
;
Feng Ye
;
Ann E. Weber
;
Xiaohua Li
;
Kathryn A. Lyons
;
William H. Parsons
;
Maria L. Garcia
;
Birgit
T.
Priest
;
McHardy M. Smith
;
John P. Felix
;
Br
;
e S. Williams
;
Gregory J. Kaczorowski
关键词:
Voltage gated sodium channel blocker
;
Neuropathic pain
;
Inflammatory pain
;
Amide replacement
;
Heterocycles
;
Isoxazoline
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2009
5.
Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain
作者:
Pengcheng P. Shao
;
Feng Ye
;
Ann E. Weber
;
Xiaohua Li
;
Kathryn A. Lyons
;
William H. Parsons
;
Maria L. Garcia
;
Birgit
T.
Priest
;
McHardy M. Smith
;
John P. Felix
;
Br
;
e S. Williams
;
Gregory J. Kaczorowski
关键词:
Voltage gated sodium channel blocker
;
Neuropathic pain
;
Inflammatory pain
;
Amide replacement
;
Heterocycles
;
Isoxazole
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2009
6.
Imidazopyridines: A novel class of hNa
v
1.7 channel blockers
作者:
Clare London
;
Scott B. Hoyt
;
William H. Parsons
;
Br
;
e S. Williams
;
Vivien A. Warren
;
Richard Tschirret-Guth
;
McHardy M. Smith
;
Birgit
T.
Priest
;
Erin McGowan
;
William J. Martin
;
Kathryn A. Lyons
;
Xiao
关键词:
Sodium channel blockers
;
hNa
v
1.7
;
Neuropathic pain
;
Voltage-gated sodium channels
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2008
7.
ProTx-I and ProTx-II: Gating modifiers of voltage-gated sodium channels
作者:
Birgit
T.
Priest
;
Kenneth M. Blumenthal
;
Jaime J. Smith
;
Vivien A. Warren
;
McHardy M. Smith
关键词:
Sodium channel
;
Gating modifier
;
Tarantula toxin
;
Inhibitory cystine knot
刊名:Toxicon
出版年:2007
8.
Sodium Channel Blockade May Contribute to the Analgesic Efficacy of Antidepressants
作者:
Ivy E. Dick
;
Richard M. Brochu
;
Yamini Purohit
;
Gregory J. Kaczorowski
;
William J. Martin
;
Birgit
T.
Priest
关键词:
Sodium channel
;
pain
;
hyperalgesia
;
antidepressants
刊名:The Journal of Pain
出版年:2007
9.
Synthesis and SAR of 1,2-trans-(1-hydroxy-3-phenylprop-1-yl)cyclopentane carboxamide derivatives, a new class of sodium channel blockers
作者:
Dong Ok
;
Chunshi Li
;
Catherine Abbadie
;
John P. Felix
;
Michael H. Fisher
;
Maria L. Garcia
;
Gregory J. Kaczorowski
;
Kathryn A. Lyons
;
William J. Martin
;
Birgit
T.
Priest
et al.
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2006
1
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