搜索页_+Capsid+inhibitors

设为首页

收藏本站

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Readers' Guide

Opening Hours
Collections
Help Via Email

Publications

Electronic Information Resources

外文资源

Elsevier电子期刊(102)

在“Elsevier电子期刊”中，命中：102条，耗时：0.0119919 秒

在所有数据库中总计命中：143条

1.Discovery of hepatitis B virus capsid assembly inhibitors leading to a heteroaryldihydropyrimidine based clinical candidate (GLS4)

作者：Qingyun Ren^a ; ^b ; Xinchang Liu^a ; ^b ; Zhonghua Luo^a ; Jing Li^a ; Chaolei Wang^a ; ^b ; Siegfried Goldmann^a ; ^{sigi@hecpharm.com} ; Jiancun Zhang^c ; Yingjun Zhang^a ; ^{zhangyingjun@hecpharm.com}

关键词：HBV ; Capsid assembly inhibitor ; SAR ; GLS4 ; Pharmacokinetics ; Safety evaluation

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

2.Tetrahalogenated benzimidazole D-ribonucleosides are active against rat cytomegalovirus

作者：Alexandra Dittmer^a ; Ina Woskobojnik^a ; Rebekka Adfeldt^a ; John C. Drach^b ; ^c ; Leroy B. Townsend^c ; ^d ; Sebastian Voigt^e ; ¹ ; Elke Bogner^a ; ¹ ; ^{elke.bogner@charite.de}

关键词：Rat cytomegalovirus ; DNA packaging ; Tetrahalogenated benzimidazoles ; Antiviral activity ; Cleavage of concatemers

刊名：Antiviral Research

出版年：2017

3.Rational Development of Hbv Capsid Inhibitors Aided by Molecular Dynamics

刊名：Biophysical Journal

出版年：2017

4.Norovirus drug candidates that inhibit viral capsid attachment to human histo-blood group antigens

作者：Eunü ; s S. Ali^a ; Harinda Rajapaksha^b ; Jillian M. Carr^c ; Nikolai Petrovsky^a ; ^b ; ^{nikolai.petrovsky@flinders.edu.au" class="auth_mail" title="E-mail the corresponding author}

关键词：Norovirus ; Human histo-blood group antigen ; Norovirus capsid proteins ; Binding inhibitors ; Antiviral therapy

刊名：Antiviral Research

出版年：2016

5.VP1 crystal structure-guided exploration and optimization of 4,5-dimethoxybenzene-based inhibitors of rhinovirus 14 infection

作者：Laurè ; ne Da Costa^a ; Manon Roche^a ; Els Scheers^b ; Antonio Coluccia^c ; Johan Neyts^b ; ^{johan.neyts@rega.kuleuven.be" class="auth_mail" title="E-mail the corresponding author} ; Thierry Terme^a ; Pieter Leyssen^b ; Romano Silvestri^c ; ^{romano.silvestri@uniroma1.it" class="auth_mail" title="E-mail the corresponding author} ; Patrice Vanelle^a ; ^{patrice.vanelle@univ-amu.fr" class="auth_mail" title="E-mail the corresponding author}

关键词：VP1 protein ; HRV14 ; Capsid inhibitors ; In silico design ; TDAE

刊名：European Journal of Medicinal Chemistry

出版年：2016

6.C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors

作者：Zheng Liu^a ; ^{Zheng.Liu@bms.com" class="auth_mail" title="E-mail the corresponding author} ; Jacob J. Swidorski^a ; Beata Nowicka-Sans^b ; Brian Terry^b ; Tricia Protack^b ; Zeyu Lin^b ; Himadri Samanta^b ; Sharon Zhang^b ; Zhufang Li^b ; Dawn D. Parker^c ; Sandhya Rahematpura^c ; Susan Jenkins^c ; Brett R. Beno^d ; Mark Krystal^b ; Nicholas A. Meanwell^a ; Ira B. Dicker^b ; Alicia Regueiro-Ren^a ; ^{Alicia.regueiroren@bms.com" class="auth_mail" title="E-mail the corresponding author}

关键词：AUC ; area under the curve ; BA ; betulinic acid ; BVM ; bevirimat ; CA ; capsid ; calcd ; calculated ; cART ; combination antiretroviral therapy ; CL ; clearance ; Cmax ; the maximum concentration of a drug in the body after dosing ; CMP ; counts per minute ; CV ; confidence value ; DCM ; methylene chloride ; DMAP ; dimethylaminopyridine ; DME ; 1 ; 2-dimethoxyethane ; DMF ; dimethylformamide ; DMSOmix or DMSO-D6_CDCl3 ; dimethyl sulfoxide-d6 mix or dimethyl sulfoxide-d6_chloroform-d ; EA ; elemental analysis ; ELSD ; evaporativ

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

7.Synthesis and evaluation of 2-pyridinylpyrimidines as inhibitors of HIV-1 structural protein assembly

作者：Milan Koží ; &scaron ; ek^a ; Ondřej &Scaron ; těpá ; nek^a ; Kamil Parkan^a ; ^&dagger ; ; Carlos Berenguer Albiñ ; ana^b ; Marcela Pá ; vová ; ^a ; ^c ; Jan Weber^a ; Hans-Georg Krӓusslich^c ; Jan Konvalinka^a ; ^d ; Ale&scaron ; Machara^b ; ^{macharaa@natur.cuni.cz" class="auth_mail" title="E-mail the corresponding author}

关键词：UWRCVJJZFORQHS-UHFFFAOYSA-N ; LEBPQOLKHNPEGD-UHFFFAOYSA-N ; KNAZTVHHVIRCNZ-UHFFFAOYSA-N ; RJUWJRIRMAHDKQ-UHFFFAOYSA-N ; VUTKUSOFURCRDB-UHFFFAOYSA-N ; RNISDQFCCHVMDJ-UHFFFAOYSA-N ; LMMCJPHXVHBJNM-UHFFFAOYSA-N ; RJPIXRWKUDKWCZ-UHFFFAOYSA-N ; ZVFWAWDAJFSPPB-UHFFFAOYSA-N ; UVXXRSZRJMHBTL-UHFFFAOYSA-N ; HGSXIQXDSKAXLW-UHFFFAOYSA-N ; FLJAMSNBOGRBJC-UHFFFAOYSA-N ; JDPOHZPUDYWJQB-UHFFFAOYSA-N ; YNGOTJDHEJUJMX-UHFFFAOYSA-N ; GMXHDZHTSKMQTC-UHFFFAOYSA-N ; QPSQEJDWSLFNDF-UHFFFAOYSA-N ; AIAAKHXDLXSTGM-UHFFFAOYSA-N ; KIQJCWJ

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

8.Molecular mechanism of a specific capsid binder resistance caused by mutations outside the binding pocket

作者：Heike Braun^a ; ^b ; ¹ ; Johannes Kirchmair^c ; ^d ; ¹ ; Mark J. Williamson^c ; Vadim A. Makarov^e ; Olga B. Riabova^e ; Robert C. Glen^c ; Andreas Sauerbrei^a ; Michaela Schmidtke^a ; ^{michaela.schmidtke@med.uni-jena.de" class="auth_mail" title="E-mail the corresponding author}

关键词：EV ; enterovirus ; CI ; capsid-binding inhibitors ; VP1&ndash4 ; viral capsid protein 1&ndash4 ; CVB3 ; coxsackievirus B3 ; HPLC ; high performance liquid chromatography ; MD ; molecular dynamics ; moi ; multiplicity of infection ; PME ; particle mesh Ewald ; RMSD ; root-mean-square deviation ; RNA ; ribonucleic acid ; RT ; reverse transcriptase ; TLC ; thin layer chromatography ; vdW ; van der Waals ; VP ; viral protein ; wt ; wild type

刊名：Antiviral Research

出版年：2015

9.New antiviral targets for innovative treatment concepts for hepatitis B virus and hepatitis delta virus

作者：David Durantel¹ ; ² ; ³ ; ^&dagger ; ; Fabien Zoulim¹ ; ² ; ³ ; ⁴ ; ⁵ ; ^&dagger ; ; ^{fabien.zoulim@inserm.fr" class="auth_mail" title="E-mail the corresponding author}

关键词：CHB ; chronic hepatitis B ; NUC ; nucleos(t)ide analogues ; PegIFN-α ; pegylated-interferon-alpha ; cccDNA ; covalently-closed-circular DNA ; siRNA or RNAi ; small interfering RNA ; HBV ; hepatitis B virus ; TLR ; toll-like receptor ; HCC ; hepatocellular carcinoma ; WHO ; world health organization ; IFN ; interferon ; HBsAg ; small envelope protein antigen ; pgRNA ; pregenomic RNA ; HDV ; hepatitis delta virus ; CHD ; chronic hepatitis D ; DAA ; direct acting antiviral ; HTA ; host-targeting antiviral ; HBpol ; HBV polymerase

刊名：Journal of Hepatology

出版年：2016

10.Dual ATPase and GTPase activity of the replication-associated protein (Rep) of beak and feather disease virus

作者：Shr-Wei Huang ; Hao-Ping Liu ; Jui-Kai Chen ; Yao-Wen Shien ; Min-Liang Wong ; Chi-Young Wang ; ^{cyoungwang@dragon.nchu.edu.tw" class="auth_mail" title="E-mail the corresponding author}

关键词：Beak and feather disease virus ; Replication-associated protein ; ATPase ; GTPase

刊名：Virus Research

出版年：2016

按检索点细分(102)

题名(13)

关键词(8)

文摘(80)

按出版年细分(102)

2027年及以后(2)

2017年(3)

2016年(8)

2015年(3)

2013年(8)

2012年(5)

2011年(9)

2010年(5)

2009年(6)

2008年(2)

2007年(6)

2006年(3)

2005年(1)

2004年(4)

2003年(6)

2002年(2)

2001年(5)

2000年(3)

2000年及以前(21)