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Elsevier电子期刊(45)

在“Elsevier电子期刊”中，命中：45条，耗时：0.021992 秒

在所有数据库中总计命中：58条

1.Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas鈥?disease

作者：R. Jeffrey Neitz^a ; Clifford Bryant^a ; Steven Chen^a ; Jiri Gut^a ; Estefania Hugo Caselli^a ; Servando Ponce^a ; Somenath Chowdhury^b ; Haichao Xu^b ; Michelle R. Arkin^a ; Jonathan A. Ellman^b ; Adam R. Renslo^a ; ^{adam.renslo@ucsf.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Chagas&rsquo ; disease ; Cruzain ; Protease inhibitors ; Pharmacokinetics ; Lead optimization

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2015

2.Variable-selection approaches to generate QSAR models for a set of antichagasic semicarbazones and analogues

作者：Marcus Tullius Scotti^a ; ^d ; ^{mtscotti@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Luciana Scotti^b ; Hamilton Mitsugu Ishiki^c ; ^d ; Leticia M. Peron^d ; Leandro de Rezende^d ; Antonia Tavares do Amaral^d

关键词：QSAR ; Semicarbazones ; Molecular descriptors ; PLS ; MLR

刊名：Chemometrics and Intelligent Laboratory Systems

出版年：2016

3.Evaluation of the leishmanicidal and cytotoxic effects of inhibitors for microorganism metabolic pathway enzymes

作者：Ademar de Mesquita Barbosa^a ; Solange dos Santos Costa^a ; Josmar Rodrigues da Rocha^b ; Carlos Alberto Montanari^b ; Selma Giorgio^a ; ^{sgiorgio@unicamp.br" class="auth_mail" title="E-mail the corresponding author}

关键词：Leishmaniosis ; Leishmania amazonensis ; Trypanosomatids ; Metabolic pathway enzymes inhibitors ; Dihydroorotate dehydrogenase

刊名：Biomedicine & Pharmacotherapy

出版年：2015

4.Benzophenone derivatives as cysteine protease inhibitors and biological activity against Leishmania(L.) amazonensis amastigotes

作者：Letí ; cia de Almeida^a ; ^{leticia.almeida.le@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Karina Ferreira Alves^a ; Claudia Mara Maciel-Rezende^b ; Larissa de Oliveira Passos Jesus^c ; Francieli Ribeiro Pires^b ; Claudio Viegas Junior^b ; Mario Augusto Izidoro^d ; Wagner Alves de Souza Jú ; dice^c ; Marcelo Henrique dos Santos^b ; Marcos José ; Marques^a

关键词：Z-F-R-MCA ; carbobenzoxicarbonil-Phe-Arg-7-amido-4-methylcoumarin ; CPs ; cysteine proteases ; MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)-2 ; 5-diphenyltetrazolium bromide ; FBS ; fetal bovine serum ; 1a ; 2-hydroxy-4-methoxybenzophenone ; 1b ; 2-hydroxy-4- O -butylbenzophenone ; 1c ; 2-hydroxy-4- O -(3 ; 3-dimethyl)-allylbenzophenone ; 2a ; 4-methoxybenzophenone ; 2b ; 4-butoxybenzophenone ; 2c ; 4- O -(3 ; 3-dimethyl)-allylbenzophenone ; 3a ; 4 ; 4&prime ; -di-methoxybenzophenone ; AmpB ; Amphotericin B ; DMSO ; dimethylsulfoxide ; IC50

刊名：Biomedicine & Pharmacotherapy

出版年：2015

5.Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of 伪-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum

作者：David J. Weldon^a ; ^e ; Falgun Shah^a ; Amar G. Chittiboyina^a ; ^d ; Anjaneyulu Sheri^a ; Raji Reddy Chada^a ; Jiri Gut^b ; Philip J. Rosenthal^b ; Develeena Shivakumar^c ; Woody Sherman^c ; Prashant Desai^a ; Jae-Chul Jung^a ; Mitchell A. Avery^a ; ^d ; ^{mavery@olemiss.edu" class="auth_mail} ; ^{mitchellavery@att.net" class="auth_mail}

关键词：Malaria ; Peptidomimetic ; Falcipain ; Cruzain ; Drug resistance

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：1 March, 2014

6.Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents

作者：Samir A. Carvalho^a ; ^b ; Larisse O. Feitosa^a ; Má ; rcio Soares^a ; Thadeu E.M.M. Costa^a ; Maria G. Henriques^a ; Kelly Salomã ; o^c ; Solange L. de Castro^c ; Marcel Kaiser^d ; Reto Brun^d ; James L. Wardell^e ; Solange M.S.V. Wardell^f ; Gustavo H.G. Trossini^g ; Adriano D. Andricopulo^h ; Edson F. da Silva^a ; Carlos A.M. Fraga^b ; ⁱ ; ^{cmfraga@ccsdecania.ufrj.br}

关键词：N-Acylhydrazone ; Cinnamic acid ; Chagas&rsquo ; disease ; Trypanosoma cruzi ; Cruzain inhibitors

刊名：European Journal of Medicinal Chemistry

出版年：2012

7.Computational study on the inhibition mechanism of cruzain by nitrile-containing molecules

作者：Oscar Mé ; ndez-Lucio^a ; Antonio Romo-Mancillas^a ; José ; L. Medina-Franco^b ; Rafael Castillo^a ; ^{rafaelc@unam.mx} ; ^{rafaelc@servidor.unam.mx}

关键词：Cruzain ; Cysteine proteases ; Density functional theory ; Semi-empirical quantum mechanics ; Trypanosoma cruzi

刊名：Journal of Molecular Graphics and Modelling

出版年：2012

8.Uncovering false positives on a virtual screening search for cruzain inhibitors

作者：Alberto Malvezzi ; Le ; ro de Rezende ; Mario Augusto Izidoro ; Maria Helena Sedenho Cezari ; Luiz Juliano ; Antonia T.-do Amaral

关键词：Virtual screening ; Promiscuous mechanism ; Cruzain inhibitors

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2008

9.Quantitative structure–activity relationships for a series of inhibitors of cruzain from Trypanosoma cruzi

作者：Gustavo H.G. Trossini ; Rafael V.C. Guido ; Glaucius Oliva ; Elizabeth I. Ferreira ; Adriano D. Andricopulo

关键词：Cruzain ; Drug design ; Chagas’ ; disease ; CoMFA ; CoMSIA

刊名：Journal of Molecular Graphics and Modelling

出版年：2009

10.Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives

作者：Jo?o Lavrado ; Zachary Mackey ; Elizabeth Hansell ; James H. McKerrow ; Alex ; ra Paulo ; Rui Moreira

关键词：Cryptolepine ; Indoloquinolines ; Trypanosoma ; Cruzain ; Rhodesain

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

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