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在“Elsevier电子期刊”中，命中：102条，耗时：0.0629698 秒

在所有数据库中总计命中：109条

1.Perturbation of genome integrity to fight pathogenic microorganisms

作者：Kinga Nyí ; ri ; ^{nyiri.kinga@ttk.mta.hu} ; Beá ; ta G. Vé ; rtessy ; ^{vertessy@mail.bme.hu}

关键词：CH2THF ; 5 ; 10-methylene tetrahydrofolate ; DCD ; dCTP deaminase ; DCD-DUT ; bifunctional dCTP deaminase&ndash ; dUTPase ; DUT ; dUTPase ; DHF ; dihydrofolate ; DHFR ; dihydrofolate reductase ; DHFR&ndash ; TS ; bifunctional dihydrofolate reductase &ndash ; thymidylate synthase ; FAD ; flavin adenine dinucleotide ; SHMT ; serine hydroxymethyltransferase ; THF ; tetrahydrofolate ; TK ; thymidine kinase ; TS ; ThyX ; classical and flavin-dependent thymidylate synthase ; TMPK ; dTMP kinase ; Ugi ; uracil-DNA glycosylase inhibitor

刊名：Biochimica et Biophysica Acta (BBA) - General Subjects

出版年：2017

2.Efficacy of artemisinin-based combination therapies for the treatment of falciparum malaria in Pakistan (2007-2015): In vivo response and dhfr and dhps mutations

作者：Qutbuddin Kakar^a ; ¹ ; Salma Sheikh^b ; ¹ ; Imran Ahmed^b ; ¹ ; Munir Ahmed Khan^c ; ¹ ; Muhammad Jamil^d ; ¹ ; Hanan ElMohammady^e ; ¹ ; Marian Warsame^f ; ¹ ; ^{warsamem@who.int" class="auth_mail" title="E-mail the corresponding author}

关键词：ACPR ; adequate clinical and parasitological response ; ACT ; artemisinin-based combination therapy ; AL ; artemether ; + ; lumefantrine ; AS ; + ; SP ; artesunate plus sulfadoxine-pyrimethamine ; DHA ; + ; PPQ ; dihydroartemisinin-piperaquine ; ETF ; early treatment failure ; LCF ; late clinical failure ; LPF ; late parasitological failure ; WHO ; World Health Organization

刊名：Acta Tropica

出版年：2016

3.Synthesis, in vitro antitumor activity, dihydrofolate reductase inhibition, DNA intercalation and structure-activity relationship studies of 1,3,5-triazine analogues

作者：Prinka Singla ; Vijay Luxami ; Kamaldeep Paul ; ^{kpaul@thapar.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：DHFR ; dihydrofolate reductase ; ct-DNA ; calf thymus DNA ; NADPH ; nicotinamide adenine dinucleotide phosphate ; TGI ; total growth inhibition ; LC50 ; 50% lethal concentration ; GI50 ; 50% growth inhibition ; IC50 ; 50% inhibitory concentration ; Ka ; binding constant

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

4.Towards understanding the unbound state of drug compounds: Implications for the intramolecular reorganization energy upon binding

作者：Nicolas Foloppe ; ^{n.foloppe@vernalis.com" class="auth_mail" title="E-mail the corresponding author} ; I-Jen Chen ; ^{i.chen@vernalis.com" class="auth_mail" title="E-mail the corresponding author}

关键词：ACE ; angiotensin converting enzyme ; DHFR ; dihydrofolate reductase ; Diel ; distance-dependent dielectric ; FF ; force field ; GB ; generalized Born solvation model ; GlobMin_Diel ; global energy minimum obtained with a distant-dependent dielectric constant ; GlobMin_GB ; global energy minimum obtained with a GB solvation model ; GlobMin_Vac ; global energy minimum obtained in vacuo ; GPU ; Graphical Processing Unit ; GUI ; graphical user interface ; LowModeMD ; search method combining low-mode moves and molecular

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

5.Design, synthesis, antibacterial activity and docking study of some new trimethoprim derivatives

作者：Umer Rashid^a ; ^b ; ^{umerrashid@ciit.net.pk" class="auth_mail" title="E-mail the corresponding author} ; ^{umer_rashid39@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Waqas Ahmad^a ; Syed Fahad Hassan^c ; Naveeda Akhtar Qureshi^d ; Basit Niaz^a ; Bakhtiar Muhammad^a ; Sameera Imdad^e ; Muhammad Sajid^e

关键词：Trimethoprim ; Dihydrofolate reductase ; Antibacterial ; Hydrophobicity ; Docking

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

6.Preparation, biological evaluation and molecular docking study of imidazolyl dihydropyrimidines as potential Mycobacterium tuberculosis dihydrofolate reductase inhibitors

作者：N.C. Desai^a ; ^{dnisheeth@rediffmail.com" class="auth_mail" title="E-mail the corresponding author} ; A.R. Trivedi^a ; Vijay M. Khedkar^b

关键词：Dihydropyrimidines ; Imidazoles ; Antitubercular activity ; Mycobacterium tuberculosis dihydrofolate reductase inhibitors ; Molecular docking ; Cytotoxicity

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

7.Development and validation of a turbulent flow chromatography and tandem mass spectrometry method for the quantitation of methotrexate and its metabolites 7-hydroxy methotrexate and DAMPA in serum

作者：Ryan C. Schofield^a ; Lakshmi V. Ramanathan^a ; Kazunori Murata^a ; Marie Grace^b ; Martin Fleisher^a ; Melissa S. Pessin^a ; Dean C. Carlow^a ; ^{carlowd@mskcc.org" class="auth_mail" title="E-mail the corresponding author} ; ^{dc8236710@yahoo.com" class="auth_mail" title="E-mail the corresponding author}

关键词：7-OH MTX ; 7-hydroxy methotrexate ; ALL ; acute lymphocytic leukemia ; CLIA ; Clinical Laboratory Improvement Amendments ; CPDG2 ; carboxypeptidase-G2 ; DAMPA ; 4-amino-4-deoxy-N10-methylpteroic acid ; DHFR ; dihydrofolate reductase ; FPIA ; fluorescence polarization immunoassay ; HESI ; heated electrospray ionization ; MTX ; methotrexate ; MTX-D3 ; deuterated methotrexate ; TFLC ; turbulent flow liquid chromatography ; VIM ; valve interface module

刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences

出版年：2015

8.Reperfusion injury and reactive oxygen species: The evolution of a concept

作者：D. Neil Granger^a ; ^{dgrang@lsuhsc.edu" class="auth_mail" title="E-mail the corresponding author} ; Peter R. Kvietys^b

关键词：A/R ; anoxia-reoxygenation ; AP-1 ; activator protein-1 ; BH4 ; tetrahydrobiopterin ; BM ; bone marrow ; CoQ ; coenzyme Q ; CuZn SOD ; copper&ndash ; zinc superoxide dismutase ; ∆ψ ; membrane potential ; DCF ; dichlorofluorescein ; DHE ; dihydroethidine ; DHFR ; dihydrofolate reductase ; DHR ; dihyrdrorhodamine ; DPI ; diphenyliodonium ; Duox ; dual oxidase ; EC ; endothelial cell ; EC-SOD ; extracellular superoxide dismutase ; ESR ; electron spin resonance ; ETC ; electron transport chain ; FAD ; flavin adenine dinucleotide ; F

刊名：Redox Biology

出版年：2015

9.Expanding the tool box for genetic manipulation of Trypanosoma cruzi

作者：Gabriela de Assis Burle-Caldas^a ; ¹ ; Viviane Grazielle-Silva^a ; ¹ ; Letí ; cia Adejani Laibida^b ; Wanderson Duarte DaRocha^b ; ^{darocha@ufpr.br" class="auth_mail" title="E-mail the corresponding author} ; Santuza Maria Ribeiro Teixeira^a ; ^{santuzat@icb.ufmg.br" class="auth_mail" title="E-mail the corresponding author}

关键词：SL ; splice leader ; nt ; nucleotide ; HR ; homologous recombination ; SM ; selectable marker ; GOI ; gene of interest ; TetR ; tetracycline repressor ; DHFR ; dihydrofolate reductase ; DDD ; dihydrofolate reductase destabilization domain ; ddFKBP ; destabilization domain of the rapamycin binding protein ; DSB ; doublecloroquine strand break ; NHEJ ; non homologous end joining ; MMEJ ; microhomology-mediated end joining ; ZFN ; zinc finger nuclease ; TALEN ; transcription activator&ndash ; like effector nuclease ; DiCRE ; dim

刊名：Molecular & Biochemical Parasitology

出版年：2015

10.Emergence of sulfadoxine-pyrimethamine resistance in Indian isolates of Plasmodium falciparum in the last two decades

作者：Amit Kumar^a ; Romilla Moirangthem^a ; Suresh Kumar Gahlawat^b ; Jagdish Chandra^c ; Purva Gupta^a ; Neena Valecha^a ; Anup Anvikar^a ; Vineeta Singh^a ; ^{vineetas_2000@yahoo.com" class="auth_mail" title="E-mail the corresponding author}

关键词：AS ; + ; SP ; artesunate ; + ; sulfadoxine&ndash ; pyrimethamine ; P. falciparum ; Plasmodium falciparum ; CQ ; chloroquine ; dhfr ; dihydrofolate reductase ; dhps ; dihydropteroate synthetase ; crt ; chloroquine resistance transporter ; mdr-1 ; multi drug resistance 1 ; SNPs ; single nucleotide polymorphisms

刊名：Infection, Genetics and Evolution

出版年：2015

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