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在“Elsevier电子期刊”中，命中：959条，耗时：0.0329806 秒

在所有数据库中总计命中：1,899条

1.The dynamic gastric environment and its impact on drug and formulation behaviour

作者：Jens Van Den Abeele¹ ; ^{jens.vandenabeele@kuleuven.be} ; Jari Rubbens¹ ; ^{jari.rubbens@kuleuven.be} ; Joachim Brouwers ^{joachim.brouwers@kuleuven.be} ; Patrick Augustijns ; ^{patrick.augustijns@kuleuven.be}

关键词：Stomach ; Gastrointestinal tract ; Drug disposition ; Biopharmaceutics ; Oral drug delivery

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

2.Gut microbiome interactions with drug metabolism, efficacy, and toxicity

作者：Ian D. Wilson ; ^{ianwilsonprof@gmail.com} ; Jeremy K. Nicholson

关键词：ADMET ; absorption ; distribution ; metabolism ; excretion ; toxicity ; AHR ; aryl hydrocarbon receptor ; AUC ; area under the curve ; BVU ; (E)-5-(2-bromovinyl) uracil ; CAR ; constitutive androstane receptor ; cMOAT ; Canalicular multispecific organic anion transporter 1 ; cgr ; cardiac glycoside reductase ; CYP450s ; cytochromes P450 ; DPD ; dihydropyrimidine dehydrogenase ; DNA ; deoxyribonucleic acid ; EPHXs ; epoxide hydrolases ; DMI&rsquos ; drug-microbiome interactions ; FDA ; Food and Drug Administration ; GF ; germ

刊名：Translational Research

出版年：2017

3.Exploring the link between gastric motility and intragastric drug distribution in man

作者：Jens Van Den Abeele^a ; ^{jens.vandenabeele@kuleuven.be} ; Joachim Brouwers^a ; ^{joachim.brouwers@kuleuven.be} ; Jan Tack^b ; ^{jan.tack@med.kuleuven.be} ; Patrick Augustijns^a ; ^{patrick.augustijns@kuleuven.be}

关键词：MMC ; Migrating Motor Complex ; TIM ; TNO Intestinal Model ; Fmoc-Cl ; 9-fluorenylmethoxy-carbonyl chloride ; Cmax ; Maximal drug concentration ; fsim ; average similarity factor ; MRI ; Magnetic Resonance Imaging

刊名：European Journal of Pharmaceutics and Biopharmaceutics

出版年：2017

4.Aerosolizable modified-release particles of montelukast improve retention and availability of the drug in the lungs

作者：Brijeshkumar Patel¹ ; Jahidur Rashid ; Fakhrul Ahsan ; ^{fakhrul.ahsan@ttuhsc.edu}

关键词：Pulmonary drug delivery ; Large porous particles ; Poly(lactic/glycolic) acid (PLGA PLA) ; Lung metabolism ; Controlled release/delivery ; Oral absorption

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

5.Neonatal pharmacology

作者：Brian J. Anderson

关键词：Drugs ; neonatal ; off-label ; paediatric ; pharmacodynamics ; pharmacokinetics ; pharmacology ; therapeutic orphan

刊名：Anaesthesia & Intensive Care Medicine

出版年：2017

6.A novel role for PHT1 in the disposition of l-histidine in brain: In vitro slice and in vivo pharmacokinetic studies in wildtype and Pht1 null mice

作者：Xiao-Xing Wang^a ; ^{xiaoxing@umich.edu} ; Yongjun Hu^a ; ^{yongjun@umich.edu} ; Richard F. Keep^b ; ^{rkeep@umich.edu} ; Noriko Toyama-Sorimachi^c ; ^{nsorima@ri.ncgm.go.jp} ; David E. Smith^a ; ^{smithb@umich.edu}

关键词：PHT1 ; l-Histidine ; Pharmacokinetics ; Biodistribution ; Brain ; Mice

刊名：Biochemical Pharmacology

出版年：2017

7.Application of target-mediated drug disposition model to predict human pharmacokinetics and target occupancy of GC1118, an anti-epidermal growth factor receptor antibody

作者：Wan-Su Park¹ ; ² ; Seunghoon Han¹ ; ² ; Jongtae Lee¹ ; ² ; Taegon Hong³ ; Dong-Seok Yim¹ ; ²

刊名：Drug Metabolism and Pharmacokinetics

出版年：2017

8.A new cell-based model to study the important matters of OATP1B on drug disposition: Genetic variants and species differences

作者：Na Li¹ ; Jie Wang¹ ; Kirsten Cooper¹ ; Joanne Bourgea¹ ; Ritu Singh² ; Tim Creegan² ; Charles L. Crespi³ ; Christopher J. Patten¹

刊名：Drug Metabolism and Pharmacokinetics

出版年：2017

9.MARK inhibitors: Declaring a No-Go decision on a chemical series based on extensive DMPK experimentation

作者：Andrew M. Haidle^a ; ; Kaleen K. Childers^a ; Anna A. Zabierek^a ; Jason D. Katz^a ; James P. Jewell^a ; Yongquan Hou^a ; Michael D. Altman^a ; Alexander Szewczak^c ; Dapeng Chen^b ; Andreas Harsch^b ; Mansuo Hayashi^d ; Lee Warren^d ; Michael Hutton^d ; Hugh Nuthall^d ; Matt G. Stanton^a ; Ian W. Davies^a ; Ben Munoz^a ; Alan Northrup^a

关键词：MARK ; Kinase ; Pharmacokinetics ; Optimization ; Physical properties ; Disposition study ; In vitro&ndash ; in vivo correlation

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

10.Novel multiple assessment of hepatocellular drug disposition in a single packaged procedure

作者：Ryosuke Takahashi^a ; ^{ryosuke.takahashi.jr@hitachi.com" class="auth_mail" title="E-mail the corresponding author} ; Hisashi Ichikawa^a ; Katsuhiro Kanda^b ; ^{katsuhiro.kanda.pv@hitachi-hightech.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Drug disposition ; Hepatocyte ; Uptake ; Basolateral efflux ; Biliary excretion ; Sandwich culture

刊名：Drug Metabolism and Pharmacokinetics

出版年：2016

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