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Elsevier电子期刊(22)

在“Elsevier电子期刊”中，命中：22条，耗时：小于0.01 秒

在所有数据库中总计命中：22条

1.Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation

作者：Dawid Panek^a ; ¹ ; Anna Więckowska^a ; ¹ ; Tomasz Wichur^a ; Marek Bajda^a ; Justyna Godyń^a ; Jakub Jończyk^a ; Kamil Mika^a ; Jana Janockova^b ; Ondrej Soukup^b ; Damijan Knez^c ; Jan Korabecny^b ; Stanislav Gobec^c ; Barbara Malawska^a ; ^{mfmalaws@cyf-kr.edu.pl}

关键词：Alzheimer's disease ; Multifunctional agents ; Acetylcholinesterase inhibitors ; BACE1 inhibitors ; Aβ aggregation ; Molecular docking

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.Design, synthesis and evaluation of novel ferulic acid-memoquin hybrids as potential multifunctional agents for the treatment of Alzheimer’s disease

作者：Wanli Pan^a ; Ke Hu^b ; Ping Bai^c ; Lintao Yu^a ; Qinge Ma^a ; Tao Li^a ; Xu Zhang^a ; Changzhong Chen^a ; Kelin Peng^a ; Wenmin Liu^a ; ^{liuwm1969@163.com" class="auth_mail" title="E-mail the corresponding author} ; Zhipei Sang^a ; ^{sangzhipei@163.com" class="auth_mail" title="E-mail the corresponding author}

关键词：AD ; Alzheimer&rsquo ; s disease ; AChE ; acetylcholinesterase ; BuChE ; butyrylcholinesterase ; Aβ ; β-amyloid peptide ; BBB ; blood&ndash ; brain barrier ; ACh ; acetylcholine ; MTDL ; multitarget-directed ligand ; EeAChE ; electric eel AChE ; CAS ; catalytic anionic site ; PAS ; peripheral anionic site ; ORAC-FL ; Oxygen Radicals Absorbance Capacity by Fluorescence ; ThT ; thioflavin T ; PAMPA-BBB ; parallel artificial membrane permeation assay of the blood&minus ; brain barrier

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

3.Pterostilbene-O-acetamidoalkylbenzylamines derivatives as novel dual inhibitors of cholinesterase with anti-β-amyloid aggregation and antioxidant properties for the treatment of Alzheimer’s disease

作者：Yuxing Li^a ; ^&dagger ; ; Xiaoming Qiang^a ; ^&dagger ; ; Yan Li^a ; Xia Yang^a ; Li Luo^a ; Ganyuan Xiao^a ; Zhongcheng Cao^a ; Zhenghuai Tan^b ; ^{tanzhh616@163.com" class="auth_mail" title="E-mail the corresponding author} ; Yong Deng^a ; ^{dengyong@scu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：AD ; Alzheimer&rsquo ; s disease ; AChE ; acetylcholinesterase ; BuChE ; butyrylcholinesterase ; HuAChE ; human AChE ; EeAChE ; Electrophorus electricus AChE ; Aβ ; β-amyloid peptide ; CAS ; catalytic active site ; PAS ; peripheral anionic site ; EDCI ; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride ; PBS ; phosphate-buffered saline ; DTNB ; 5 ; 5&prime ; -dithiobis-2-nitrobenzoic acid ; PDB ; Protein Data Bank ; TcAChE ; Torpedo californica AChE ; ORAC-FL ; Oxygen Radicals Absorbance Capacity by Fluorescence ; ThT

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

4.Expression and characterization of a codon-optimized butyrylcholinesterase for analysis of organophosphate insecticide residues

作者：Jing-jing TIAN^a ; ^{416718211@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Xiang-ning CHEN^a ; ^{chenxiangning@bua.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Yuan-hong XIE^a ; Yong LU^b ; Wen-tao XU^c ; Li XU^a ; Bin DU^a

关键词：butyrylcholinesterase ; organophosphate insecticide residues ; Pichia pastoris ; expression ; codon-optimized

刊名：Journal of Integrative Agriculture

出版年：2016

5.Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer’s disease

作者：Sai-Sai Xie^&dagger ; ; Jin-Shuai Lan^&dagger ; ; Xiaobing Wang ; Zhi-Min Wang ; Neng Jiang ; Fan Li ; Jia-Jia Wu ; Jin Wang ; Ling-Yi Kong ; ^{cpu_lykong@126.com" class="auth_mail" title="E-mail the corresponding author}

关键词：BOXHJLTYYUXRSS-UHFFFAOYSA-N ; HXYMYZXCUHALCL-UHFFFAOYSA-N ; OLXGWSKUULDSEJ-UHFFFAOYSA-N ; VCCISXVIIKLUNO-UHFFFAOYSA-N ; XATVGNRTOUJFHU-UHFFFAOYSA-N ; LQNPMZWHOLIOEU-UHFFFAOYSA-N ; GKYZWZKQBZYQOH-UHFFFAOYSA-N ; FDDWWWOIEISVTE-UHFFFAOYSA-N ; KOAOVWXOZSDQBP-UHFFFAOYSA-N ; JURRMYXCDPPYMK-UHFFFAOYSA-N ; IPJZSNUPIXZHAU-UHFFFAOYSA-N ; UUZIPHVUUZOBHC-UHFFFAOYSA-N ; QZRBOLHGJBENEV-UHFFFAOYSA-N ; PDEVIVJKZGXTTC-UHFFFAOYSA-N ; HZEOKPNLIUABIQ-UHFFFAOYSA-N

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

6.Toxicological and pharmacological evaluation, antioxidant, ADMET and molecular modeling of selected racemic chromenotacrines {11-amino-12-aryl-8,9,10,12-tetrahydro-7H-chromeno[2,3-b]quinolin-3-ols} for the potential prevention and treatment of Alzheimer's disease

作者：Marí ; a Jesú ; s Oset-Gasque^a ; ^b ; ^{mjoset@ucm.es" class="auth_mail} ; Marí ; a Pilar Gonzá ; lez^a ; Javier Pé ; rez-Peñ ; a^a ; Nuria Garcí ; a-Font^a ; Alejandro Romero^c ; Javier del Pino^c ; Eva Ramos^c ; Dimitra Hadjipavlou-Litina^d ; Elena Soriano^e ; Mourad Chioua^f ; Abdelouahid Samadi^f ; Dushyant S. Raghuvanshi^g ; Krishna N. Singh^g ; ^{knsinghbhu@yahoo.co.in" class="auth_mail} ; José ; Marco-Contelles^f ; ^b ; ^{iqoc21@iqog.csic.es" class="auth_mail}

关键词：11-Amino-12-aryl-89 ; 10 ; 12-tetrahydro-7H-chromeno[2 ; 3-b]quinolin-3-ols ; Tacrine analogs ; Toxicity ; EeAChE ; hBuChE ; Kinetic analysis ; Inhibition mechanism ; Antioxidant ; Neuroprotection ; Molecular modeling ; ADMET ; Alzheimer's disease

刊名：European Journal of Medicinal Chemistry

出版年：3 March, 2014

7.Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease

作者：Oscar M. Bautista-Aguilera^a ; ¹ ; Gerard Esteban^b ; ¹ ; Irene Bolea^b ; Katarina Nikolic^c ; Danica Agbaba^c ; Ignacio Moraleda^d ; Isabel Iriepa^d ; Abdelouahid Samadi^a ; Elena Soriano^e ; Mercedes Unzeta^b ; José ; Marco-Contelles^a ; ^{iqoc21@iqog.csic.es" class="auth_mail}

关键词：Donepezil ; Donepezil&ndash ; indolyl hybrids ; EeAChE ; eqBuChE ; hMAO A ; hMAO B ; Inhibitors ; 3D-QSAR ; Molecular modeling ; ADMET

刊名：European Journal of Medicinal Chemistry

出版年：21 March, 2014

8.Synthesis, cytotoxicity and molecular modelling studies of new phenylcinnamide derivatives as potent inhibitors of cholinesterases

作者：Aamer Saeed^a ; Parvez Ali Mahesar^a ; Sumera Zaib^b ; Muhammad Siraj Khan^b ; Abdul Matin^c ; Mohammad Shahid^d ; Jamshed Iqbal^b ; ^e ; ^{drjamshed@ciit.net.pk" class="auth_mail} ; ^{jamshediqb@gmail.com" class="auth_mail}

关键词：Phenylcinnamide derivatives ; Alzheimer's disease ; Cholinesterases inhibitors ; Cytotoxicity ; Molecular docking

刊名：European Journal of Medicinal Chemistry

出版年：6 May, 2014

9.1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: Synthesis, pharmacological evaluation and mechanistic studies

作者：Ornella Di Pietro ; Elisabet Viayna ; Esther Vicente-Garc铆a ; Manuela Bartolini ; Rosario Ram贸n ; Jordi Ju谩rez-Jim茅nez ; M. Vict貌ria Clos ; Bel茅n P茅rez ; Vincenza Andrisano ; F. Javier Luque ; Rodolfo Lavilla ; Diego Mu帽oz-Torrero

关键词：Benzo[h][1 ; 6]naphthyridines ; Povarov reaction ; Dual inhibitors ; AChE PAS binding ; AChE midgorge binding

刊名：European Journal of Medicinal Chemistry

出版年：12 February, 2014

10.Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors

作者：Ay?e Selcen Alpan ; S¨¹l¨¹nay Parlar ; Luca Carlino ; Ayse H ; e Tarikogullari ; Vildan Alpt¨¹z¨¹n ; Hasan Semih G¨¹ne?

关键词：AChE ; acetylcholinesterase ; BuChE ; butyrylcholinesterase ; AD ; Alzheimer&rsquo ; s disease ; AChEI ; acetylcholinesterase inhibitors ; A¦Â ; ¦Â-amyloid ; PAS ; peripheral anionic site ; eeAChE ; Electrophorus electricus AChE ; TcAChE ; Torpedo californica AChE ; hAChE

刊名：Bioorganic and Medicinal Chemistry

出版年：2013

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