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Elsevier电子期刊(29)
ACS电子期刊(5)
在“
Elsevier电子期刊
”中,
命中:
29
条,耗时:小于0.01 秒
在所有数据库中总计命中:
34
条
1.
Ten years of dengue drug discovery: Progress and prospects
作者:
Siew Pheng Lim
;
Qing-Yin Wang
;
Christian G. Noble
;
Yen-Liang Chen
;
Hongping Dong
;
Bin Zou
;
Fumiaki
Yokokawa
;
Shahul Nilar
;
Paul Smith
;
David Beer
;
Julien Lescar
;
Pei-Yong Shi
关键词:
DENV
;
dengue virus
;
WNV
;
West Nile virus
;
YFV
;
yellow fever virus
;
TBEV
;
tick-borne encephalitis virus
;
HCV
;
hepatitis C virus
;
WEEV
;
Western equine encephalitis virus
;
VSV
;
vesicular stomatitis virus
;
HBV
;
hepatitis B virus
;
HIV
;
human immunodeficiency virus
;
DAA
;
direct antiviral agent
;
PI
;
protease inhibitors
;
HTS
;
high-throughput screening
;
MTase
;
methyltransferase
;
RdRp
;
RNA-dependent RNA polymerase
;
NI
;
nucleoside analog inhibitors
;
NNI
;
non-nucleoside inhibitor
;
PoC
;
proof-of-concept
;
TI
刊名:Antiviral Research
出版年:November, 2013
2.
Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides
作者:
Michal Tichy
;
Radek Pohl
;
Hao Ying Xu
;
Yen-Liang Chen
;
Fumiaki
Yokokawa
;
Pei-Yong Shi
;
Michal Hocek
关键词:
Nucleosides
;
Pyrimido[4
;
5-b]indoles
;
Suzuki and Stille cross-coupling
;
Anti-dengue virus activity
刊名:Bioorganic and Medicinal Chemistry
出版年:2012
3.
Possible protective role of pregnenolone-16α-carbonitrile in lithocholic acid-induced hepatotoxicity through enhanced hepatic lipogenesis
作者:
Masaaki Miyata
;
Masahiro Nomoto
;
Fumiaki
Sotodate
;
Tomohiro Mizuki
;
Wataru Hori
;
Miho Nagayasu
;
Shinya
Yokokawa
;
Shin-ichi Ninomiya
;
Yasushi Yamazoe
关键词:
Lithocholic acid
;
PCN
;
Hepatotoxicity
;
PXR
;
Lipogenesis
;
Phospholipid
刊名:European Journal of Pharmacology
出版年:2010
4.
Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-Cyanopyrimidines. Part 2
作者:
Osamu Irie
;
Takatoshi Kosaka
;
Masashi Kishida
;
Junichi Sakaki
;
Keiichi Masuya
;
Kazuhide Konishi
;
Fumiaki
Yokokawa
;
Takeru Ehara
;
Atsuko Iwasaki
;
Yuki Iwaki
;
Yuko Hitomi
;
Atsushi Toyao
;
Hiroki Gunji
;
N
关键词:
Cathepsin S inhibitor
;
Brain-penetrating
;
hERG
;
Multiple sclerosis
;
Neuropathic pain
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2008
5.
Discovery of selective and nonpeptidic cathepsin S inhibitors
作者:
Osamu Irie
;
Takeru Ehara
;
Atsuko Iwasaki
;
Fumiaki
Yokokawa
;
Junichi Sakaki
;
Hajime Hirao
;
Takanori Kanazawa
;
Naoki Teno
;
Miyuki Horiuchi
;
Ichiro Umemura
;
Hiroki Gunji
;
Keiichi Masuya
;
Yuko Hitomi
;
Gen
关键词:
Cathepsin S inhibitor
;
Pyrrolopyrimidine
;
Nitrile
;
Nonpeptidic
;
Cysteine protease
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2008
6.
4-Amino-2-cyanopyrimidines: Novel scaffold for nonpeptidic cathepsin S inhibitors
作者:
Osamu Irie
;
Fumiaki
Yokokawa
;
Takeru Ehara
;
Atsuko Iwasaki
;
Yuki Iwaki
;
Yuko Hitomi
;
Kazuhide Konishi
;
Masashi Kishida
;
Atsushi Toyao
;
Keiichi Masuya
;
Hiroki Gunji
;
Junichi Sakaki
;
Genji Iwasaki
;
Haji
关键词:
Pyrimidine
;
Cathepsin S inhibitors
;
Nitrile
;
Cysteine protease
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2008
7.
Synthetic studies of the cyclic depsipeptides bearing the 3-amino-6-hydroxy-2-piperidone (Ahp) unit. Total synthesis of the proposed structure of micropeptin T-20
作者:
Yokokawa
;
Fumiaki
;
Inaizumi
;
Akiko
;
Shioiri
;
Takayuki
关键词:
Total synthesis
;
Cyclic depsipeptide
;
Macrolactamization
;
Hemiaminal
;
Cyanobacteria
刊名:Tetrahedron
出版年:2005
8.
An expeditious total synthesis of kalkitoxins: determination of the absolute stereostructure of natural kalkitoxin
作者:
Yokokawa
;
Fumiaki
;
Asano
;
Toshinobu
;
Okino
;
Tatsufumi
;
Gerwick
;
William H.
;
Shioiri
;
Takayuki
关键词:
Kalkitoxin
;
Marine cyanobacteria
;
Total synthesis
;
Absolute configuration
;
Stereoselective 1
;
4-addition
刊名:Tetrahedron
出版年:2004
9.
Total synthesis of mycothiazole, a polyketide heterocycle from marine sponges
作者:
Sugiyama
;
Hideyuki
;
Yokokawa
;
Fumiaki
;
Shioiri
;
Takayuki
关键词:
chemical manganese dioxide
;
Stille coupling
;
aldol reaction
;
marine natural product
;
absolute configuration
刊名:Tetrahedron
出版年:2003
10.
Total synthesis and conformational studies of ceratospongamide, a bioactive cyclic heptapeptide from marine origin
作者:
Yokokawa
;
Fumiaki
;
Sameshima
;
Hirofumi
;
In
;
Yasuko
;
Minoura
;
Katsuhiko
;
Ishida
;
Toshimasa
;
et. al.
关键词:
cis
;
cis-ceratospongamide
;
trans
;
trans-[d-allo-Ile] ceratospongamide
;
thermodynamic isomerization
;
synthesis
;
conformation
刊名:Tetrahedron
出版年:2002
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